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    Cemip cell migration inducing protein, hyaluronan binding [ Mus musculus (house mouse) ]

    Gene ID: 80982, updated on 28-Oct-2024

    Summary

    Official Symbol
    Cemipprovided by MGI
    Official Full Name
    cell migration inducing protein, hyaluronan bindingprovided by MGI
    Primary source
    MGI:MGI:2443629
    See related
    Ensembl:ENSMUSG00000052353 AllianceGenome:MGI:2443629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hybid; Kiaa1199; 12H19.01.T7; 6330404C01Rik; 9930013L23Rik
    Summary
    Enables hyaluronic acid binding activity and hyalurononglucosaminidase activity. Involved in hyaluronan catabolic process. Located in clathrin-coated vesicle membrane. Is expressed in several structures, including nervous system; retina; and testis. Orthologous to human CEMIP (cell migration inducing hyaluronidase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in ovary adult (RPKM 4.8), testis adult (RPKM 1.2) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Cemip in Genome Data Viewer
    Location:
    7 D3; 7 48.35 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83582065..83735893, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83932857..84086693, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110009M11 gene Neighboring gene STARR-seq mESC enhancer starr_19414 Neighboring gene STARR-positive B cell enhancer ABC_E9696 Neighboring gene STARR-positive B cell enhancer ABC_E448 Neighboring gene talin rod domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_19417 Neighboring gene mesoderm development LRP chaperone Neighboring gene STARR-seq mESC enhancer starr_19418 Neighboring gene STARR-seq mESC enhancer starr_19420 Neighboring gene predicted gene, 30440 Neighboring gene STARR-seq mESC enhancer starr_19424 Neighboring gene STARR-seq mESC enhancer starr_19425 Neighboring gene STARR-seq mESC enhancer starr_19426 Neighboring gene abhydrolase domain containing 17C Neighboring gene predicted gene, 26708 Neighboring gene predicted gene, 53174 Neighboring gene predicted gene, 39044

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ER retention sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ER retention sequence binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin heavy chain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyaluronic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hyalurononglucosaminidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hyalurononglucosaminidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyalurononglucosaminidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaluronan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hyaluronan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cell migration-inducing and hyaluronan-binding protein
    Names
    hyaluronan binding protein involved in hyaluronan depolymerization
    protein 12H19.01.T7
    NP_109653.3
    XP_006508416.1
    XP_006508417.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030728.4NP_109653.3  cell migration-inducing and hyaluronan-binding protein precursor

      See identical proteins and their annotated locations for NP_109653.3

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC154141, AK036809, AK162689, BC086772
      Consensus CDS
      CCDS21416.1
      UniProtKB/Swiss-Prot
      E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
      UniProtKB/TrEMBL
      Q14AX8
      Related
      ENSMUSP00000063277.6, ENSMUST00000064174.12
      Conserved Domains (4) summary
      cd13938
      Location:141303
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:47165
      G8; G8 domain
      pfam13330
      Location:325403
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      cl19122
      Location:12051361
      PANDER_like; Domains similar to the Pancreatic-derived factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      83582065..83735893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508354.4XP_006508417.1  cell migration-inducing and hyaluronan-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006508417.1

      UniProtKB/Swiss-Prot
      E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
      UniProtKB/TrEMBL
      Q14AX8
      Conserved Domains (4) summary
      cd13938
      Location:141303
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:47165
      G8; G8 domain
      pfam13330
      Location:325403
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      cl19122
      Location:12051361
      PANDER_like; Domains similar to the Pancreatic-derived factor
    2. XM_006508353.4XP_006508416.1  cell migration-inducing and hyaluronan-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006508416.1

      UniProtKB/Swiss-Prot
      E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
      UniProtKB/TrEMBL
      Q14AX8
      Conserved Domains (4) summary
      cd13938
      Location:141303
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:47165
      G8; G8 domain
      pfam13330
      Location:325403
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      cl19122
      Location:12051361
      PANDER_like; Domains similar to the Pancreatic-derived factor