TMEM74 transmembrane protein 74 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMEM74provided by HGNC
Official Full Name: transmembrane protein 74provided by HGNC
Primary source: HGNC:HGNC:26409
See related: Ensembl:ENSG00000164841 MIM:613935; AllianceGenome:HGNC:26409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NET36
Summary: Predicted to enable transmembrane transporter binding activity. Involved in macroautophagy. Predicted to be located in cytoplasmic vesicle; plasma membrane; and vacuolar membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in brain (RPKM 1.7), heart (RPKM 0.4) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q23.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (108606850..108787594, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (109735330..109916112, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (109619079..109799823, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia.
Title: Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia.
The results suggested that TMEM74 acts as an oncogene and a potential diagnostic marker and a therapeutic target for liver cancer and lung cancer.
Title: The Expression of TMEM74 in Liver Cancer and Lung Cancer Correlating With Survival Outcomes.
TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.
Title: TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.
the results revealed the autophagy modulator TMEM74 interrelates with apoptosis inducer BIK and inhibits its function.
Title: Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
These findings demonstrate that TMEM74 may be involved in promoting functional autophagy during cell starvation and other stress conditions.
Title: TMEM74, a lysosome and autophagosome protein, regulates autophagy.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BCD2347 (e-PCR)
- UniSTS:67696

RH92459 (e-PCR)
- UniSTS:93056

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in general adaptation syndrome, behavioral process	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.