SLC8A1 solute carrier family 8 member A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC8A1provided by HGNC
Official Full Name: solute carrier family 8 member A1provided by HGNC
Primary source: HGNC:HGNC:11068
See related: Ensembl:ENSG00000183023 MIM:182305; AllianceGenome:HGNC:11068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NCX1
Summary: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Expression: Broad expression in heart (RPKM 35.6), endometrium (RPKM 9.9) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p22.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (40097270..40512435, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (40106262..40521419, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (40324410..40739575, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
Title: In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.
Title: Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.
LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Title: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
Title: Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.
Title: NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.
Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.
Title: Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.
Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.
Title: Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.
NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/beta-catenin pathway.
Title: NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.
Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
Title: Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.
Title: circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults. EBI GWAS Catalog EBI GWAS CatalogPubMed
A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH121294 (e-PCR)
- UniSTS:138560

D2S2328 (e-PCR), detects polymorphism
- UniSTS:32334

SLC8A1__3866 (e-PCR)
- UniSTS:462930

WI-16830 (e-PCR)
- UniSTS:58200

SHGC-89339 (e-PCR)
- UniSTS:170590

D2S2749 (e-PCR)
- UniSTS:7781

D1S1425 (e-PCR)
- UniSTS:149621

SHGC-151269 (e-PCR)
- UniSTS:173685

RH18469 (e-PCR)
- UniSTS:2166

Cda11b02 (e-PCR)
- UniSTS:33405

RH121523 (e-PCR)
- UniSTS:133760

NoName (e-PCR)
- UniSTS:481157

AFMB335XC1 (e-PCR)
- UniSTS:45980

SHGC-172311 (e-PCR)
- UniSTS:183452

SLC8A1 (e-PCR), detects polymorphism
- UniSTS:480166

SHGC-61992 (e-PCR)
- UniSTS:20670

NoName (e-PCR)
- UniSTS:484033

STS-Z40873 (e-PCR)
- UniSTS:69584

D2S2658 (e-PCR)
- UniSTS:63696

SHGC-81024 (e-PCR)
- UniSTS:102640

Clone Names

FLJ37694, FLJ43417, MGC119581, DKFZp779F0871

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium:sodium antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:sodium antiporter activity	TAS Traceable Author Statement more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion export	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane import into cytosol	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in cell communication by electrical coupling involved in cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to caffeine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization during cardiac muscle cell action potential	TAS Traceable Author Statement more info	PubMed
involved_in monoatomic ion transport	TAS Traceable Author Statement more info
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of the force of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac conduction	TAS Traceable Author Statement more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell communication by electrical coupling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of the force of heart contraction	IC Inferred by Curator more info	PubMed
involved_in regulation of the force of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in relaxation of cardiac muscle	IC Inferred by Curator more info	PubMed
involved_in relaxation of cardiac muscle	TAS Traceable Author Statement more info	PubMed
involved_in relaxation of smooth muscle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to muscle stretch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in T-tubule	ISS Inferred from Sequence or Structural Similarity more info
located_in T-tubule	TAS Traceable Author Statement more info	PubMed
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	TAS Traceable Author Statement more info	PubMed
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium/calcium exchanger 1

Names: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112800.4 → NP_001106271.1 sodium/calcium exchanger 1 isoform B precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS46265.1

UniProtKB/Swiss-Prot

P32418

UniProtKB/TrEMBL

Q4QQH3

Related

ENSP00000385678.3, ENST00000405901.7

Conserved Domains (1) summary

TIGR00845
Location:4 → 968

caca; sodium/calcium exchanger 1
NM_001112801.3 → NP_001106272.1 sodium/calcium exchanger 1 isoform C precursor

See identical proteins and their annotated locations for NP_001106272.1

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92742.1

UniProtKB/Swiss-Prot

P32418

Related

ENSP00000516142.1, ENST00000705604.1

Conserved Domains (5) summary

smart00237
Location:537 → 627

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

TIGR00845
Location:4 → 960

caca; sodium/calcium exchanger 1

pfam01699
Location:787 → 951

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03160
Location:406 → 496

Calx-beta; Calx-beta domain

pfam16494
Location:254 → 384

Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
NM_001112802.2 → NP_001106273.1 sodium/calcium exchanger 1 isoform D precursor

See identical proteins and their annotated locations for NP_001106273.1

Status: VALIDATED

Source sequence(s)

AC007254, AK291696

Consensus CDS

CCDS46264.1

UniProtKB/Swiss-Prot

P32418

Related

ENSP00000385188.1, ENST00000402441.5

Conserved Domains (1) summary

TIGR00845
Location:4 → 937

caca; sodium/calcium exchanger 1
NM_001252624.2 → NP_001239553.1 sodium/calcium exchanger 1 isoform E precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377

Consensus CDS

CCDS59430.1

UniProtKB/Swiss-Prot

P32418

Related

ENSP00000384908.2, ENST00000408028.6

Conserved Domains (1) summary

TIGR00845
Location:4 → 965

caca; sodium/calcium exchanger 1
NM_001351483.2 → NP_001338412.1 sodium/calcium exchanger 1 isoform F precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92746.1

UniProtKB/TrEMBL

E9PB98

Conserved Domains (1) summary

TIGR00845
Location:4 → 945

caca; sodium/calcium exchanger 1
NM_001351484.2 → NP_001338413.1 sodium/calcium exchanger 1 isoform F precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92746.1

UniProtKB/TrEMBL

E9PB98

Related

ENSP00000412560.2, ENST00000417271.2

Conserved Domains (1) summary

TIGR00845
Location:4 → 945

caca; sodium/calcium exchanger 1
NM_001351485.2 → NP_001338414.1 sodium/calcium exchanger 1 isoform F precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS92746.1

UniProtKB/TrEMBL

E9PB98

Conserved Domains (1) summary

TIGR00845
Location:4 → 945

caca; sodium/calcium exchanger 1
NM_001351486.2 → NP_001338415.1 sodium/calcium exchanger 1 isoform G precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92743.1

UniProtKB/TrEMBL

A0A994J7E1

Related

ENSP00000516110.1, ENST00000705282.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 944

caca; sodium/calcium exchanger 1
NM_001351487.2 → NP_001338416.1 sodium/calcium exchanger 1 isoform H precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92745.1

UniProtKB/TrEMBL

A0A994J4U7

Related

ENSP00000516141.1, ENST00000705603.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 961

caca; sodium/calcium exchanger 1
NM_001351488.2 → NP_001338417.1 sodium/calcium exchanger 1 isoform H precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS92745.1

UniProtKB/TrEMBL

A0A994J4U7

Related

ENSP00000516109.1, ENST00000705281.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 961

caca; sodium/calcium exchanger 1
NM_001351489.2 → NP_001338418.1 sodium/calcium exchanger 1 isoform H precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS92745.1

UniProtKB/TrEMBL

A0A994J4U7

Conserved Domains (1) summary

TIGR00845
Location:4 → 961

caca; sodium/calcium exchanger 1
NM_001351490.2 → NP_001338419.1 sodium/calcium exchanger 1 isoform I precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92744.1

UniProtKB/TrEMBL

A0A994J7G2

Conserved Domains (1) summary

TIGR00845
Location:4 → 938

caca; sodium/calcium exchanger 1
NM_001351491.2 → NP_001338420.1 sodium/calcium exchanger 1 isoform I precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92744.1

UniProtKB/TrEMBL

A0A994J7G2

Related

ENSP00000516143.1, ENST00000705605.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 938

caca; sodium/calcium exchanger 1
NM_001351492.2 → NP_001338421.1 sodium/calcium exchanger 1 isoform I precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS92744.1

UniProtKB/TrEMBL

A0A994J7G2

Conserved Domains (1) summary

TIGR00845
Location:4 → 938

caca; sodium/calcium exchanger 1
NM_001351493.2 → NP_001338422.1 sodium/calcium exchanger 1 isoform E precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS59430.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 965

caca; sodium/calcium exchanger 1
NM_001351494.2 → NP_001338423.1 sodium/calcium exchanger 1 isoform D precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS46264.1

Related

ENSP00000383886.1, ENST00000406785.7

Conserved Domains (1) summary

TIGR00845
Location:4 → 937

caca; sodium/calcium exchanger 1
NM_001372263.2 → NP_001359192.1 sodium/calcium exchanger 1 isoform A precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877

Consensus CDS

CCDS1806.1

UniProtKB/Swiss-Prot

A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6

Related

ENSP00000384763.1, ENST00000403092.5

Conserved Domains (1) summary

TIGR00845
Location:4 → 973

caca; sodium/calcium exchanger 1
NM_001394103.1 → NP_001381032.1 sodium/calcium exchanger 1 isoform A precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877

Consensus CDS

CCDS1806.1

UniProtKB/Swiss-Prot

A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6

Conserved Domains (1) summary

TIGR00845
Location:4 → 973

caca; sodium/calcium exchanger 1
NM_001394104.1 → NP_001381033.1 sodium/calcium exchanger 1 isoform B precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS46265.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 968

caca; sodium/calcium exchanger 1
NM_001394105.1 → NP_001381034.1 sodium/calcium exchanger 1 isoform H precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS92745.1

UniProtKB/TrEMBL

A0A994J4U7

Conserved Domains (1) summary

TIGR00845
Location:4 → 961

caca; sodium/calcium exchanger 1
NM_001394106.1 → NP_001381035.1 sodium/calcium exchanger 1 isoform D precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS46264.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 937

caca; sodium/calcium exchanger 1
NM_001394107.1 → NP_001381036.1 sodium/calcium exchanger 1 isoform D precursor

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC106048

Consensus CDS

CCDS46264.1

Conserved Domains (1) summary

TIGR00845
Location:4 → 937

caca; sodium/calcium exchanger 1
NM_021097.5 → NP_066920.1 sodium/calcium exchanger 1 isoform A precursor

See identical proteins and their annotated locations for NP_066920.1

Status: VALIDATED

Source sequence(s)

AC007254, AC007281, AC007377, AC007877, AC106048

Consensus CDS

CCDS1806.1

UniProtKB/Swiss-Prot

A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6

Related

ENSP00000332931.4, ENST00000332839.9

Conserved Domains (1) summary

TIGR00845
Location:4 → 973

caca; sodium/calcium exchanger 1