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    TRIM14 tripartite motif containing 14 [ Homo sapiens (human) ]

    Gene ID: 9830, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIM14provided by HGNC
    Official Full Name
    tripartite motif containing 14provided by HGNC
    Primary source
    HGNC:HGNC:16283
    See related
    Ensembl:ENSG00000106785 MIM:606556; AllianceGenome:HGNC:16283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM14 in Genome Data Viewer
    Location:
    9q22.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (98035797..98119222, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110207739..110291169, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100846635..100881504, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20110 Neighboring gene uncharacterized LOC124902225 Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:100797789-100798988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28684 Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene uncharacterized LOC124902227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100833954-100834454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100836915-100837721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849215-100849889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849890-100850563 Neighboring gene N-acetylneuraminate synthase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:100852934-100853493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28692 Neighboring gene coronin 2A Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:100921913-100922413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100924760-100925260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100933363-100934198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100935871-100936704 Neighboring gene Sharpr-MPRA regulatory region 7304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100953772-100954426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100957663-100958179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100960535-100961402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100961403-100962270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100963511-100964012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100964013-100964512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100965136-100965636 Neighboring gene Sharpr-MPRA regulatory region 378 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:100984952-100986151 Neighboring gene TBC1 domain family member 2 Neighboring gene microRNA 6854

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway. Wei S, et al. Carcinogenesis, 2024 May 19. PMID 38267812
    2. Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways. Nenasheva VV, et al. Genes Immun, 2021 May. PMID 33864033
    3. Enhanced expression of trim14 gene suppressed Sindbis virus reproduction and modulated the transcription of a large number of genes of innate immunity. Nenasheva VV, et al. Immunol Res, 2015 Jul. PMID 25948474
    4. Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway. Xiao F, et al. Drug Dev Res, 2020 Aug. PMID 32096264
    5. TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein. Wang S, et al. Sci Rep, 2016 Aug 31. PMID 27578425, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.
      Title: Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.
    2. Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
      Title: Trim14-IκBα Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
    3. TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway.
      Title: TRIM14 suppressed the progression of NSCLC via hexosamine biosynthesis pathway.
    4. TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1alpha Pathway.
      Title: TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1α Pathway.
    5. Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
      Title: Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
    6. Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
      Title: Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
    7. miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
      Title: miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
    8. Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
      Title: Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
    9. miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
      Title: miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
    10. Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
      Title: Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0129

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 14
    Names
    tripartite motif protein TRIM14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014788.4 → NP_055603.2  tripartite motif-containing protein 14

      See identical proteins and their annotated locations for NP_055603.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AA469446, AK292825, AL137073, BF797334
      Consensus CDS
      CCDS6734.1
      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
      Related
      ENSP00000344208.2, ENST00000341469.7
      Conserved Domains (1) summary
      cd13738
      Location:269 → 441
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    2. NM_033219.3 → NP_150088.1  tripartite motif-containing protein 14

      See identical proteins and their annotated locations for NP_150088.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also referred to as alpha) is alternatively spliced in the 3' UTR, compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AA469446, AF220130, AL137073, BF797334
      Consensus CDS
      CCDS6734.1
      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
      Related
      ENSP00000343990.3, ENST00000342043.3
      Conserved Domains (1) summary
      cd13738
      Location:269 → 441
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      98035797..98119222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424162.1 → XP_047280118.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    2. XM_047424161.1 → XP_047280117.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    3. XM_047424160.1 → XP_047280116.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
      Related
      ENSP00000364239.3, ENST00000375098.7

    4. XM_017015353.3 → XP_016870842.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
      Conserved Domains (1) summary
      cd13738
      Location:269 → 441
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    5. XM_005252320.5 → XP_005252377.1  tripartite motif-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_005252377.1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
      Conserved Domains (1) summary
      cd13738
      Location:269 → 441
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    6. XM_047424163.1 → XP_047280119.1  tripartite motif-containing protein 14 isoform X2

    7. XM_047424164.1 → XP_047280120.1  tripartite motif-containing protein 14 isoform X2

    8. XM_011519244.3 → XP_011517546.1  tripartite motif-containing protein 14 isoform X3

      Conserved Domains (1) summary
      cd13738
      Location:112 → 284
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    RNA

    1. XR_929880.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      110207739..110291169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364293.1 → XP_054220268.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    2. XM_054364292.1 → XP_054220267.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    3. XM_054364291.1 → XP_054220266.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    4. XM_054364290.1 → XP_054220265.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    5. XM_054364289.1 → XP_054220264.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/Swiss-Prot
      A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

    6. XM_054364294.1 → XP_054220269.1  tripartite motif-containing protein 14 isoform X2

    7. XM_054364295.1 → XP_054220270.1  tripartite motif-containing protein 14 isoform X2

    8. XM_054364296.1 → XP_054220271.1  tripartite motif-containing protein 14 isoform X3

    RNA

    1. XR_008488114.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033220.1: Suppressed sequence

      Description
      NM_033220.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_033221.1: Suppressed sequence

      Description
      NM_033221.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with poorly supported non-consensus splice sites in the 3' coding region.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14142.2 GenPept UniProtKB/Swiss-Prot:Q14142

    Gene LinkOut

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