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    PTPRA protein tyrosine phosphatase receptor type A [ Homo sapiens (human) ]

    Gene ID: 5786, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PTPRAprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Aprovided by HGNC
    Primary source
    HGNC:HGNC:9664
    See related
    Ensembl:ENSG00000132670 MIM:176884; AllianceGenome:HGNC:9664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 49.1), thyroid (RPKM 27.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTPRA in Genome Data Viewer
    Location:
    20p13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (2864184..3038669)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2895030..3069415)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2844830..3019315)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12607 Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene chromosome 20 open reading frame 141 Neighboring gene transmembrane protein 239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2812614-2813114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2820603-2821134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2821668-2822199 Neighboring gene PC-esterase domain containing 1A Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2840338-2840838 Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852243-2852874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852875-2853504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2853505-2854136 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2854137-2854766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60029 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2903375-2903875 Neighboring gene Sharpr-MPRA regulatory region 1396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17473 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:3007535-3008734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17475 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene gonadotropin releasing hormone 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. Yahiro K, et al. J Biol Chem, 2003 May 23. PMID 12626515
    2. Rare variants in Protein tyrosine phosphatase, receptor type A (PTPRA) in schizophrenia: Evidence from a family based study. John J, et al. Schizophr Res, 2019 Apr. PMID 30594456, Free PMC Article
    3. Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521. Nakano M, et al. Dis Model Mech, 2016 Dec 1. PMID 27935824, Free PMC Article
    4. Resequencing and association analysis of PTPRA, a possible susceptibility gene for schizophrenia and autism spectrum disorders. Xing J, et al. PLoS One, 2014. PMID 25393624, Free PMC Article
    5. Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea. Suh YJ, et al. J Korean Med Sci, 2013 Mar. PMID 23487342, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucose-mediated N-glycosylation of RPTPalpha affects its subcellular localization and Src activation.
      Title: Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.
    2. Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family?
      Title: Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family?
    3. CircPTPRA blocks the recognition of RNA N(6)-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.
      Title: CircPTPRA blocks the recognition of RNA N(6)-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.
    4. Receptor-type protein tyrosine phosphatase alpha (PTPalpha) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.
      Title: Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.
    5. RPTPalpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
      Title: RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
    6. Filtered data from WES, combined with in silico analyses revealed a novel heterozygous missense variant (NM_080841:c.1730C>G:p.T577R; exon18) in Protein tyrosine phosphatase, receptor type A (PTPRA 20p13) in an Indian family with schizophrenia. Screening for variants in this gene in the WES data of an independent schizophrenia cohort (n=350) of matched ethnicity, identified five additional rare missense variants.
      Title: Rare variants in Protein tyrosine phosphatase, receptor type A (PTPRA) in schizophrenia: Evidence from a family based study.
    7. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cell adhesion molecules involved in mediating neuronal development. The binding of LAR-RPTPs to extracellular ligands induces local clustering of LAR-RPTPs to regulate axon growth and synaptogenesis. LAR-RPTPs interact with synaptic liprin-alpha proteins via the two cytoplasmic phosphatase domains, D1 and D2.
      Title: Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity.
    8. miR-146a-5p may negatively regulate the PTPRA-SRC signaling to inhibit expression of fibrosis-related markers in irradiated and TGF-beta1-stimulated LX2 cells
      Title: MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.
    9. HePTP plays a key role in the metastasis of triple-negative breast cancer via activating Wnt/beta-catenin signaling.
      Title: HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/β-catenin signaling.
    10. circPTPRA suppresses EMT and metastasis of NSCLC cell lines by sponging miR-96-5p, which upregulates the downstream tumor suppressor RASSF8.
      Title: The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase alpha
    Names
    Leukocyte common antigen-related peptide (protein tyrosine phosphate)
    PTPLCA-related phosphatase
    PTPase-alpha
    protein tyrosine phosphatase, receptor type, alpha polypeptide
    protein-tyrosine phosphatase alpha
    tyrosine phosphatase alpha
    NP_001372231.1
    NP_001372232.1
    NP_001372233.1
    NP_001372234.1
    NP_001372235.1
    NP_001372236.1
    NP_001372237.1
    NP_001372239.1
    NP_001372240.1
    NP_001372241.1
    NP_001372242.1
    NP_001372243.1
    NP_001372244.1
    NP_001372245.1
    NP_001372246.1
    NP_001372247.1
    NP_001372248.1
    NP_001372249.1
    NP_001372250.1
    NP_001375249.1
    NP_001375250.1
    NP_001375251.1
    NP_001375252.1
    NP_001375253.1
    NP_002827.1
    NP_543030.1
    NP_543031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385302.1 → NP_001372231.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z2A4, E7ET72
      Conserved Domains (2) summary
      cd14621
      Location:225 → 520
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:574 → 801
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    2. NM_001385303.1 → NP_001372232.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z2A4, E7ET72
      Conserved Domains (2) summary
      cd14621
      Location:225 → 520
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:574 → 801
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    3. NM_001385304.1 → NP_001372233.1  receptor-type tyrosine-protein phosphatase alpha isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      A0A1S5UZ22, B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:216 → 511
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:565 → 792
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    4. NM_001385305.1 → NP_001372234.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Related
      ENSP00000382787.2, ENST00000399903.7
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    5. NM_001385306.1 → NP_001372235.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    6. NM_001385307.1 → NP_001372236.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    7. NM_001385308.1 → NP_001372237.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    8. NM_001385310.1 → NP_001372239.1  receptor-type tyrosine-protein phosphatase alpha isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:216 → 511
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:565 → 789
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    9. NM_001385311.1 → NP_001372240.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13039.1
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:205 → 500
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:554 → 781
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    10. NM_001385312.1 → NP_001372241.1  receptor-type tyrosine-protein phosphatase alpha isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:205 → 500
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:554 → 780
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    11. NM_001385313.1 → NP_001372242.1  receptor-type tyrosine-protein phosphatase alpha isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      cd14623
      Location:464 → 691
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:270 → 389
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    12. NM_001385314.1 → NP_001372243.1  receptor-type tyrosine-protein phosphatase alpha isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      cd14623
      Location:462 → 689
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:268 → 387
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. NM_001385315.1 → NP_001372244.1  receptor-type tyrosine-protein phosphatase alpha isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      cd14623
      Location:453 → 680
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:259 → 378
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    14. NM_001385316.1 → NP_001372245.1  receptor-type tyrosine-protein phosphatase alpha isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:99 → 394
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:448 → 675
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    15. NM_001385317.1 → NP_001372246.1  receptor-type tyrosine-protein phosphatase alpha isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:91 → 386
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:440 → 667
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    16. NM_001385318.1 → NP_001372247.1  receptor-type tyrosine-protein phosphatase alpha isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      PHA02740
      Location:245 → 348
      PHA02740; protein tyrosine phosphatase; Provisional
      cd14623
      Location:424 → 651
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    17. NM_001385319.1 → NP_001372248.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      PHA02740
      Location:243 → 346
      PHA02740; protein tyrosine phosphatase; Provisional
      cd14623
      Location:422 → 649
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    18. NM_001385320.1 → NP_001372249.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      PHA02740
      Location:243 → 346
      PHA02740; protein tyrosine phosphatase; Provisional
      cd14623
      Location:422 → 649
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    19. NM_001385321.1 → NP_001372250.1  receptor-type tyrosine-protein phosphatase alpha isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Conserved Domains (2) summary
      PHA02740
      Location:234 → 337
      PHA02740; protein tyrosine phosphatase; Provisional
      cd14623
      Location:413 → 640
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    20. NM_001388320.1 → NP_001375249.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    21. NM_001388321.1 → NP_001375250.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13039.1
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:205 → 500
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:554 → 781
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    22. NM_001388322.1 → NP_001375251.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4F4
      Conserved Domains (2) summary
      cd14623
      Location:237 → 464
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:1 → 183
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    23. NM_001388323.1 → NP_001375252.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4F4
      Conserved Domains (2) summary
      cd14623
      Location:237 → 464
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:1 → 183
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    24. NM_001388324.1 → NP_001375253.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      UniProtKB/TrEMBL
      B7Z4F4
      Conserved Domains (2) summary
      cd14623
      Location:237 → 464
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
      cl28904
      Location:1 → 183
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    25. NM_002836.4 → NP_002827.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_002827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK090743, AL161656, BC027308, M34668
      Consensus CDS
      CCDS13038.1
      UniProtKB/Swiss-Prot
      A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
      UniProtKB/TrEMBL
      B7Z4Q5
      Conserved Domains (2) summary
      cd14621
      Location:214 → 509
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:563 → 790
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    26. NM_080840.3 → NP_543030.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_543030.1

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13039.1
      UniProtKB/TrEMBL
      B7Z4Q5
      Related
      ENSP00000216877.6, ENST00000216877.10
      Conserved Domains (2) summary
      cd14621
      Location:205 → 500
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:554 → 781
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    27. NM_080841.3 → NP_543031.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_543031.1

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656
      Consensus CDS
      CCDS13039.1
      UniProtKB/TrEMBL
      B7Z4Q5
      Related
      ENSP00000314568.5, ENST00000318266.9
      Conserved Domains (2) summary
      cd14621
      Location:205 → 500
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:554 → 781
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

    RNA

    1. NR_170936.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121905, AL161656

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      2864184..3038669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      2895030..3069415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18433.3 GenPept UniProtKB/Swiss-Prot:P18433

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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