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    LRRFIP2 LRR binding FLII interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 9209, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LRRFIP2provided by HGNC
    Official Full Name
    LRR binding FLII interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:6703
    See related
    Ensembl:ENSG00000093167 MIM:614043; AllianceGenome:HGNC:6703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUFI-2
    Summary
    The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRFIP2 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37052626..37176360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37053969..37177703, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37094117..37217851, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:37035199-37035710 Neighboring gene EPM2A interacting protein 1 Neighboring gene mutL homolog 1 Neighboring gene ribosomal protein L29 pseudogene 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37178613-37178766 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 2 Neighboring gene RNA, U6 small nuclear 1301, pseudogene Neighboring gene UBE2F pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:37217333-37217834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:37217835-37218334 Neighboring gene uncharacterized LOC105377642 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S16 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families. Pinheiro M, et al. Genet Med, 2011 Oct. PMID 21785361
    2. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Liu J, et al. Proc Natl Acad Sci U S A, 2005 Feb 8. PMID 15677333, Free PMC Article
    3. F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2. Burger D, et al. Sci Rep, 2016 Jul 19. PMID 27431477, Free PMC Article
    4. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. Gunawardena HP, et al. J Biol Chem, 2011 Apr 1. PMID 21220426, Free PMC Article
    5. Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. Buchsbaum S, et al. Biochem Biophys Res Commun, 2012 Nov 9. PMID 23036196

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
      Title: F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2.
    2. FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 moiety.
      Title: Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.
    3. A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families
      Title: A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families.
    4. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
      Title: Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. LRR-binding MyD88 interactor LRRFIP2 is a positive regulator of NF-kappa B activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4-mediated inflammatory response.
      Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
    7. These data suggest that LRRFIP2 plays an important role in transducing Wnt signals.
      Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20248, FLJ22683, FLJ58304, DKFZp434H2035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables LRR domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 2
    Names
    LRR FLII-interacting protein 2
    leucine rich repeat (in FLII) interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053016.1 RefSeqGene

      Range
      7236..129192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134369.2 → NP_001127841.1  leucine-rich repeat flightless-interacting protein 2 isoform k

      See identical proteins and their annotated locations for NP_001127841.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (k, also known as 3) is shorter, compared to isoform a.
      Source sequence(s)
      AK024692, BC017703, DC336346, R27776
      Consensus CDS
      CCDS46791.1
      UniProtKB/Swiss-Prot
      Q9Y608
      Related
      ENSP00000416364.2, ENST00000421276.6
      Conserved Domains (2) summary
      pfam04111
      Location:329 → 424
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 349
      LRRFIP; LRRFIP family

    2. NM_001282691.1 → NP_001269620.1  leucine-rich repeat flightless-interacting protein 2 isoform d

      See identical proteins and their annotated locations for NP_001269620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d, also known as 4) is shorter, compared to isoform a.
      Source sequence(s)
      AK024692, AK302282, DB033703, R27776
      Consensus CDS
      CCDS63592.1
      UniProtKB/Swiss-Prot
      Q9Y608
      Related
      ENSP00000379705.2, ENST00000396428.6
      Conserved Domains (1) summary
      pfam09738
      Location:130 → 428
      DUF2051; Double stranded RNA binding protein (DUF2051)

    3. NM_001348297.1 → NP_001335226.1  leucine-rich repeat flightless-interacting protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:525 → 620
      APG6; Autophagy protein Apg6
      pfam09738
      Location:246 → 545
      LRRFIP; LRRFIP family

    4. NM_001348298.1 → NP_001335227.1  leucine-rich repeat flightless-interacting protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:455 → 550
      APG6; Autophagy protein Apg6
      pfam09738
      Location:152 → 475
      LRRFIP; LRRFIP family

    5. NM_001348299.1 → NP_001335228.1  leucine-rich repeat flightless-interacting protein 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a. Variants 7 and 8 both encode the same isoform (e).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:397 → 492
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 417
      LRRFIP; LRRFIP family

    6. NM_001348300.1 → NP_001335229.1  leucine-rich repeat flightless-interacting protein 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a. Variants 7 and 8 both encode the same isoform (e).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:397 → 492
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 417
      LRRFIP; LRRFIP family

    7. NM_001348301.1 → NP_001335230.1  leucine-rich repeat flightless-interacting protein 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (f) is shorter, compared to isoform a. Variants 9 and 10 both encode the same isoform (f).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 414
      LRRFIP; LRRFIP family
      cl25732
      Location:187 → 488
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001348302.1 → NP_001335231.1  leucine-rich repeat flightless-interacting protein 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (f) is shorter, compared to isoform a. Variants 9 and 10 both encode the same isoform (f).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 414
      LRRFIP; LRRFIP family
      cl25732
      Location:187 → 488
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_001348303.1 → NP_001335232.1  leucine-rich repeat flightless-interacting protein 2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (g) is shorter, compared to isoform a.
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:373 → 468
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 393
      LRRFIP; LRRFIP family

    10. NM_001348304.1 → NP_001335233.1  leucine-rich repeat flightless-interacting protein 2 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (h) is shorter, compared to isoform a.
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:370 → 465
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 390
      LRRFIP; LRRFIP family

    11. NM_001348305.1 → NP_001335234.1  leucine-rich repeat flightless-interacting protein 2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:363 → 458
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 383
      LRRFIP; LRRFIP family

    12. NM_001348306.1 → NP_001335235.1  leucine-rich repeat flightless-interacting protein 2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:363 → 458
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 383
      LRRFIP; LRRFIP family

    13. NM_001348307.1 → NP_001335236.1  leucine-rich repeat flightless-interacting protein 2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:363 → 458
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 383
      LRRFIP; LRRFIP family

    14. NM_001348308.1 → NP_001335237.1  leucine-rich repeat flightless-interacting protein 2 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a. Variants 16 and 17 both encode the same isoform (j).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:339 → 434
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 359
      LRRFIP; LRRFIP family

    15. NM_001348309.1 → NP_001335238.1  leucine-rich repeat flightless-interacting protein 2 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a. Variants 16 and 17 both encode the same isoform (j).
      Source sequence(s)
      AC006583, AC126118
      Conserved Domains (2) summary
      pfam04111
      Location:339 → 434
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 359
      LRRFIP; LRRFIP family

    16. NM_001348310.1 → NP_001335239.1  leucine-rich repeat flightless-interacting protein 2 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (k) is shorter, compared to isoform a. Variants 3 and 18 both encode the same isoform (k).
      Source sequence(s)
      AC006583, AC126118
      Consensus CDS
      CCDS46791.1
      UniProtKB/Swiss-Prot
      Q9Y608
      Related
      ENSP00000405480.1, ENST00000440230.5
      Conserved Domains (2) summary
      pfam04111
      Location:329 → 424
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 349
      LRRFIP; LRRFIP family

    17. NM_001348311.1 → NP_001335240.1  leucine-rich repeat flightless-interacting protein 2 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l) is shorter, compared to isoform a. Variants 2 and 19 both encode the same isoform (l).
      Source sequence(s)
      AC006583, AC126118
      Consensus CDS
      CCDS2665.1
      UniProtKB/Swiss-Prot
      Q9Y608
      Conserved Domains (2) summary
      pfam04111
      Location:305 → 400
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 325
      LRRFIP; LRRFIP family

    18. NM_006309.4 → NP_006300.1  leucine-rich repeat flightless-interacting protein 2 isoform a

      See identical proteins and their annotated locations for NP_006300.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1).
      Source sequence(s)
      AF115509, AK024692, BC053668, R27776
      Consensus CDS
      CCDS2664.1
      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Related
      ENSP00000338727.4, ENST00000336686.9
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    19. NM_017724.2 → NP_060194.1  leucine-rich repeat flightless-interacting protein 2 isoform l

      See identical proteins and their annotated locations for NP_060194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l, also known as 2) is shorter, compared to isoform a.
      Source sequence(s)
      AK024692, BC053668, DC336346, R27776
      Consensus CDS
      CCDS2665.1
      UniProtKB/Swiss-Prot
      Q9Y608
      Related
      ENSP00000346349.4, ENST00000354379.8
      Conserved Domains (2) summary
      pfam04111
      Location:305 → 400
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 325
      LRRFIP; LRRFIP family

    RNA

    1. NR_145514.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC126118

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      37052626..37176360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713396.2 → XP_006713459.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

      Conserved Domains (2) summary
      pfam09738
      Location:256 → 610
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam13870
      Location:386 → 483
      DUF4201; Domain of unknown function (DUF4201)

    2. XM_024453826.2 → XP_024309594.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A1S5UZ17
      Conserved Domains (2) summary
      pfam04111
      Location:339 → 434
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 359
      LRRFIP; LRRFIP family

    3. XM_017007473.2 → XP_016862962.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

    4. XM_017007479.2 → XP_016862968.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    5. XM_017007471.2 → XP_016862960.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

    6. XM_047449204.1 → XP_047305160.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

    7. XM_006713389.2 → XP_006713452.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006713452.1

      Conserved Domains (3) summary
      pfam04111
      Location:609 → 704
      APG6; Autophagy protein Apg6
      pfam04156
      Location:382 → 505
      IncA; IncA protein
      pfam09738
      Location:275 → 629
      LRRFIP; LRRFIP family

    8. XM_017007472.2 → XP_016862961.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

    9. XM_005265551.2 → XP_005265608.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

      Conserved Domains (1) summary
      pfam09738
      Location:47 → 465
      DUF2051; Double stranded RNA binding protein (DUF2051)

    10. XM_047449202.1 → XP_047305158.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

    11. XM_006713388.2 → XP_006713451.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

      Conserved Domains (2) summary
      pfam09738
      Location:276 → 630
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam13870
      Location:406 → 503
      DUF4201; Domain of unknown function (DUF4201)

    12. XM_006713385.2 → XP_006713448.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

      Conserved Domains (2) summary
      pfam09738
      Location:291 → 645
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam13870
      Location:421 → 518
      DUF4201; Domain of unknown function (DUF4201)

    13. XM_006713387.2 → XP_006713450.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

      Conserved Domains (1) summary
      pfam09738
      Location:277 → 631
      DUF2051; Double stranded RNA binding protein (DUF2051)

    14. XM_006713397.2 → XP_006713460.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

      Conserved Domains (1) summary
      pfam09738
      Location:218 → 574
      DUF2051; Double stranded RNA binding protein (DUF2051)

    15. XM_047449203.1 → XP_047305159.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

    16. XM_006713393.2 → XP_006713456.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

      Conserved Domains (1) summary
      pfam09738
      Location:262 → 616
      DUF2051; Double stranded RNA binding protein (DUF2051)

    17. XM_017007469.2 → XP_016862958.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

    18. XM_017007467.2 → XP_016862956.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

    19. XM_006713392.2 → XP_006713455.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

      Conserved Domains (2) summary
      pfam09738
      Location:292 → 622
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam13870
      Location:398 → 495
      DUF4201; Domain of unknown function (DUF4201)

    20. XM_011534222.2 → XP_011532524.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

      Conserved Domains (2) summary
      pfam09738
      Location:292 → 581
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam17031
      Location:348 → 404
      DUF5101; Domain of unknown function (DUF5101)

    21. XM_006713395.2 → XP_006713458.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

      Conserved Domains (3) summary
      pfam09738
      Location:292 → 615
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cd16269
      Location:462 → 475
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:342 → 482
      GBP_C; Guanylate-binding protein, C-terminal domain

    22. XM_011534217.2 → XP_011532519.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011532519.1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    23. XM_017007476.2 → XP_016862965.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 414
      LRRFIP; LRRFIP family
      cl25732
      Location:187 → 488
      SMC_N; RecF/RecN/SMC N terminal domain

    24. XM_047449205.1 → XP_047305161.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

    25. XM_047449207.1 → XP_047305163.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    26. XM_006713390.2 → XP_006713453.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006713453.1

      Conserved Domains (3) summary
      pfam04111
      Location:609 → 704
      APG6; Autophagy protein Apg6
      pfam04156
      Location:382 → 505
      IncA; IncA protein
      pfam09738
      Location:275 → 629
      LRRFIP; LRRFIP family

    27. XM_011534218.2 → XP_011532520.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011532520.1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    28. XM_011534219.2 → XP_011532521.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011532521.1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    29. XM_024453824.2 → XP_024309592.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

      Conserved Domains (2) summary
      pfam04111
      Location:370 → 465
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 390
      LRRFIP; LRRFIP family

    30. XM_047449208.1 → XP_047305164.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A1S5UZ17

    31. XM_047449206.1 → XP_047305162.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    32. XM_024453821.2 → XP_024309589.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

      Conserved Domains (3) summary
      pfam04111
      Location:563 → 658
      APG6; Autophagy protein Apg6
      pfam04156
      Location:336 → 459
      IncA; IncA protein
      pfam09738
      Location:229 → 583
      LRRFIP; LRRFIP family

    33. XM_024453820.2 → XP_024309588.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      Conserved Domains (3) summary
      pfam04111
      Location:609 → 704
      APG6; Autophagy protein Apg6
      pfam04156
      Location:382 → 505
      IncA; IncA protein
      pfam09738
      Location:275 → 629
      LRRFIP; LRRFIP family

    34. XM_005265539.3 → XP_005265596.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005265596.1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    35. XM_005265540.2 → XP_005265597.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005265597.1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608
      Conserved Domains (2) summary
      pfam09738
      Location:292 → 646
      LRRFIP; LRRFIP family
      pfam11932
      Location:662 → 721
      DUF3450; Protein of unknown function (DUF3450)

    36. XM_047449201.1 → XP_047305157.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      37053969..37177703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348390.1 → XP_054204365.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

    2. XM_054348409.1 → XP_054204384.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A1S5UZ17

    3. XM_054348403.1 → XP_054204378.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

    4. XM_054348406.1 → XP_054204381.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    5. XM_054348400.1 → XP_054204375.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

    6. XM_054348398.1 → XP_054204373.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

    7. XM_054348384.1 → XP_054204359.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

    8. XM_054348401.1 → XP_054204376.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

    9. XM_054348399.1 → XP_054204374.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

    10. XM_054348395.1 → XP_054204370.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

    11. XM_054348383.1 → XP_054204358.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

    12. XM_054348381.1 → XP_054204356.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

    13. XM_054348382.1 → XP_054204357.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

    14. XM_054348394.1 → XP_054204369.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

    15. XM_054348397.1 → XP_054204372.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

    16. XM_054348388.1 → XP_054204363.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

    17. XM_054348396.1 → XP_054204371.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

    18. XM_054348391.1 → XP_054204366.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

    19. XM_054348387.1 → XP_054204362.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

    20. XM_054348393.1 → XP_054204368.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

    21. XM_054348389.1 → XP_054204364.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

    22. XM_054348375.1 → XP_054204350.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    23. XM_054348404.1 → XP_054204379.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

    24. XM_054348402.1 → XP_054204377.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

    25. XM_054348408.1 → XP_054204383.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    26. XM_054348386.1 → XP_054204361.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

    27. XM_054348377.1 → XP_054204352.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    28. XM_054348379.1 → XP_054204354.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    29. XM_054348405.1 → XP_054204380.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

    30. XM_054348410.1 → XP_054204385.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A1S5UZ17

    31. XM_054348407.1 → XP_054204382.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    32. XM_054348392.1 → XP_054204367.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

    33. XM_054348385.1 → XP_054204360.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

    34. XM_054348376.1 → XP_054204351.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    35. XM_054348378.1 → XP_054204353.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    36. XM_054348380.1 → XP_054204355.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y608.1 GenPept UniProtKB/Swiss-Prot:Q9Y608

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