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    ZMYM1 zinc finger MYM-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 79830, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZMYM1provided by HGNC
    Official Full Name
    zinc finger MYM-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:26253
    See related
    Ensembl:ENSG00000197056 AllianceGenome:HGNC:26253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYM
    Summary
    Predicted to enable protein dimerization activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.0), ovary (RPKM 2.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZMYM1 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (35059786..35118818)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (34922450..34978527)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35525387..35581460)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903990 Neighboring gene ribosomal protein L12 pseudogene 45 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35544893-35545411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:35555322-35555822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 722 Neighboring gene EF-hand calcium binding domain 14 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35594172-35594351 Neighboring gene uncharacterized LOC105378644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article
    2. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, et al. Mol Cell, 2018 Dec 6. PMID 30415952
    3. Identification and functional characterization of transcriptional activators in human cells. Alerasool N, et al. Mol Cell, 2022 Feb 3. PMID 35016035
    4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. So J, et al. Sci Signal, 2015 Apr 7. PMID 25852190
    5. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23151, FLJ43753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 1
    Names
    zinc finger, MYM domain containing 1
    zinc finger, MYM-type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289088.2 → NP_001276017.1  zinc finger MYM-type protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276017.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK026804, AK125741, BC037313, BX537537
      Consensus CDS
      CCDS41302.1
      UniProtKB/Swiss-Prot
      D3DPR7, Q5SVZ6, Q7Z3Q4
      UniProtKB/TrEMBL
      B4DSJ9
      Related
      ENSP00000482579.1, ENST00000611874.4
      Conserved Domains (5) summary
      smart00597
      Location:452 → 531
      ZnF_TTF; zinc finger in transposases and transcription factors
      smart00746
      Location:135 → 175
      TRASH; metallochaperone-like domain
      pfam05699
      Location:1029 → 1118
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:83 → 121
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:496 → 728
      DUF4371; Domain of unknown function (DUF4371)

    2. NM_001289089.2 → NP_001276018.1  zinc finger MYM-type protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AL607089
      UniProtKB/TrEMBL
      B4DSJ9
      Conserved Domains (4) summary
      smart00597
      Location:433 → 512
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:1010 → 1099
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:130 → 171
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:477 → 709
      DUF4371; Domain of unknown function (DUF4371)

    3. NM_001289090.2 → NP_001276019.1  zinc finger MYM-type protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AL607089
      Consensus CDS
      CCDS41302.1
      UniProtKB/Swiss-Prot
      D3DPR7, Q5SVZ6, Q7Z3Q4
      UniProtKB/TrEMBL
      B4DSJ9
      Related
      ENSP00000362427.1, ENST00000373330.1
      Conserved Domains (5) summary
      smart00597
      Location:452 → 531
      ZnF_TTF; zinc finger in transposases and transcription factors
      smart00746
      Location:135 → 175
      TRASH; metallochaperone-like domain
      pfam05699
      Location:1029 → 1118
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:83 → 121
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:496 → 728
      DUF4371; Domain of unknown function (DUF4371)

    4. NM_001289091.2 → NP_001276020.1  zinc finger MYM-type protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AL607089
      UniProtKB/TrEMBL
      B4DSJ9, Q9H5R2
      Conserved Domains (3) summary
      smart00597
      Location:92 → 171
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:700 → 758
      Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
      pfam14291
      Location:133 → 367
      DUF4371; Domain of unknown function (DUF4371)

    5. NM_001319955.2 → NP_001306884.1  zinc finger MYM-type protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL607089
      UniProtKB/TrEMBL
      B4DSJ9
      Related
      ENST00000373329.5
      Conserved Domains (5) summary
      smart00597
      Location:377 → 456
      ZnF_TTF; zinc finger in transposases and transcription factors
      smart00746
      Location:60 → 100
      TRASH; metallochaperone-like domain
      pfam05699
      Location:954 → 1043
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:8 → 46
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:421 → 653
      DUF4371; Domain of unknown function (DUF4371)

    6. NM_024772.5 → NP_079048.3  zinc finger MYM-type protein 1 isoform a

      See identical proteins and their annotated locations for NP_079048.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AL607089
      Consensus CDS
      CCDS41302.1
      UniProtKB/Swiss-Prot
      D3DPR7, Q5SVZ6, Q7Z3Q4
      UniProtKB/TrEMBL
      B4DSJ9
      Related
      ENSP00000352920.4, ENST00000359858.9
      Conserved Domains (5) summary
      smart00597
      Location:452 → 531
      ZnF_TTF; zinc finger in transposases and transcription factors
      smart00746
      Location:135 → 175
      TRASH; metallochaperone-like domain
      pfam05699
      Location:1029 → 1118
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:83 → 121
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:496 → 728
      DUF4371; Domain of unknown function (DUF4371)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      35059786..35118818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430815.1 → XP_047286771.1  zinc finger MYM-type protein 1 isoform X9

    2. XM_047430816.1 → XP_047286772.1  zinc finger MYM-type protein 1 isoform X7

    3. XM_047430818.1 → XP_047286774.1  zinc finger MYM-type protein 1 isoform X8

    4. XM_047430777.1 → XP_047286733.1  zinc finger MYM-type protein 1 isoform X2

    5. XM_047430783.1 → XP_047286739.1  zinc finger MYM-type protein 1 isoform X3

    6. XM_047430786.1 → XP_047286742.1  zinc finger MYM-type protein 1 isoform X1

    7. XM_011542166.4 → XP_011540468.3  zinc finger MYM-type protein 1 isoform X7

      Related
      ENSP00000394233.1, ENST00000417119.5

    8. XM_047430814.1 → XP_047286770.1  zinc finger MYM-type protein 1 isoform X8

    9. XM_011542163.4 → XP_011540465.3  zinc finger MYM-type protein 1 isoform X1

    10. XM_017002358.2 → XP_016857847.1  zinc finger MYM-type protein 1 isoform X4

      UniProtKB/TrEMBL
      B4DSJ9
      Conserved Domains (5) summary
      smart00597
      Location:377 → 456
      ZnF_TTF; zinc finger in transposases and transcription factors
      smart00746
      Location:60 → 100
      TRASH; metallochaperone-like domain
      pfam05699
      Location:954 → 1043
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam06467
      Location:8 → 46
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam14291
      Location:421 → 653
      DUF4371; Domain of unknown function (DUF4371)

    11. XM_024449827.2 → XP_024305595.1  zinc finger MYM-type protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DSJ9
      Conserved Domains (3) summary
      smart00597
      Location:261 → 340
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:838 → 927
      Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
      pfam14291
      Location:302 → 536
      DUF4371; Domain of unknown function (DUF4371)

    12. XM_047430803.1 → XP_047286759.1  zinc finger MYM-type protein 1 isoform X5

    13. XM_024449824.2 → XP_024305592.1  zinc finger MYM-type protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DSJ9
      Conserved Domains (3) summary
      smart00597
      Location:261 → 340
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:838 → 927
      Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
      pfam14291
      Location:302 → 536
      DUF4371; Domain of unknown function (DUF4371)

    14. XM_024449833.2 → XP_024305601.1  zinc finger MYM-type protein 1 isoform X6

      Conserved Domains (3) summary
      smart00597
      Location:92 → 171
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam05699
      Location:700 → 758
      Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
      pfam14291
      Location:133 → 367
      DUF4371; Domain of unknown function (DUF4371)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      34922450..34978527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338785.1 → XP_054194760.1  zinc finger MYM-type protein 1 isoform X2

    2. XM_054338795.1 → XP_054194770.1  zinc finger MYM-type protein 1 isoform X9

    3. XM_054338786.1 → XP_054194761.1  zinc finger MYM-type protein 1 isoform X3

    4. XM_054338783.1 → XP_054194758.1  zinc finger MYM-type protein 1 isoform X10

    5. XM_054338793.1 → XP_054194768.1  zinc finger MYM-type protein 1 isoform X12

    6. XM_054338784.1 → XP_054194759.1  zinc finger MYM-type protein 1 isoform X11

    7. XM_054338794.1 → XP_054194769.1  zinc finger MYM-type protein 1 isoform X13

    8. XM_054338796.1 → XP_054194771.1  zinc finger MYM-type protein 1 isoform X7

    9. XM_054338787.1 → XP_054194762.1  zinc finger MYM-type protein 1 isoform X1

    10. XM_054338797.1 → XP_054194772.1  zinc finger MYM-type protein 1 isoform X8

    11. XM_054338788.1 → XP_054194763.1  zinc finger MYM-type protein 1 isoform X4

    12. XM_054338789.1 → XP_054194764.1  zinc finger MYM-type protein 1 isoform X5

    13. XM_054338790.1 → XP_054194765.1  zinc finger MYM-type protein 1 isoform X5

    14. XM_054338791.1 → XP_054194766.1  zinc finger MYM-type protein 1 isoform X5

    15. XM_054338792.1 → XP_054194767.1  zinc finger MYM-type protein 1 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SVZ6.1 GenPept UniProtKB/Swiss-Prot:Q5SVZ6

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