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    MIER2 MIER family member 2 [ Homo sapiens (human) ]

    Gene ID: 54531, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MIER2provided by HGNC
    Official Full Name
    MIER family member 2provided by HGNC
    Primary source
    HGNC:HGNC:29210
    See related
    Ensembl:ENSG00000105556 MIM:620092; AllianceGenome:HGNC:29210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mi-er2; KIAA1193
    Summary
    Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIER2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (305573..344796, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (255525..294230, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (305573..344796, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:281525-282216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:282217-282907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287125-287626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287627-288126 Neighboring gene hESC enhancers GRCh37_chr19:289901-290599 and GRCh37_chr19:290600-291297 Neighboring gene phospholipid phosphatase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:293997-294846 Neighboring gene uncharacterized LOC124904605 Neighboring gene MPRA-validated peak3203 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:327661-328161 Neighboring gene MPRA-validated peak3205 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:341127-341714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:342901-343852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9599 Neighboring gene MPRA-validated peak3207 silencer Neighboring gene MPRA-validated peak3208 silencer Neighboring gene sperm microtubule associated protein 2 Neighboring gene uncharacterized LOC124904606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:383808-384334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:384335-384861 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:386621-387186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
    2. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Lee Y, et al. Carcinogenesis, 2013 Feb. PMID 23144319
    3. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff M, et al. Nat Biotechnol, 2011 Mar. PMID 21258344
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
    5. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mesoderm induction early response protein 2
    Names
    mesoderm induction early response 1, family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346105.2 → NP_001333034.1  mesoderm induction early response protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC016588
      Conserved Domains (2) summary
      cd11661
      Location:266 → 310
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:161 → 211
      ELM2; ELM2 domain

    2. NM_001387152.1 → NP_001374081.1  mesoderm induction early response protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (2) summary
      cd11661
      Location:304 → 348
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199 → 249
      ELM2; ELM2 domain

    3. NM_001387153.1 → NP_001374082.1  mesoderm induction early response protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (3) summary
      cd11661
      Location:302 → 346
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      TIGR01649
      Location:353 → 457
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam01448
      Location:197 → 247
      ELM2; ELM2 domain

    4. NM_001387154.1 → NP_001374083.1  mesoderm induction early response protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (3) summary
      cd11661
      Location:266 → 310
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      TIGR01649
      Location:317 → 421
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      pfam01448
      Location:161 → 211
      ELM2; ELM2 domain

    5. NM_001387155.1 → NP_001374084.1  mesoderm induction early response protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (2) summary
      cd11661
      Location:266 → 310
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:161 → 211
      ELM2; ELM2 domain

    6. NM_001387156.1 → NP_001374085.1  mesoderm induction early response protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (2) summary
      cd11661
      Location:218 → 262
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:113 → 163
      ELM2; ELM2 domain

    7. NM_001387157.1 → NP_001374086.1  mesoderm induction early response protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC016588
      Conserved Domains (2) summary
      cd11661
      Location:218 → 262
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:113 → 163
      ELM2; ELM2 domain

    8. NM_017550.3 → NP_060020.1  mesoderm induction early response protein 2 isoform 1

      See identical proteins and their annotated locations for NP_060020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC016588
      Consensus CDS
      CCDS32855.1
      UniProtKB/Swiss-Prot
      Q8N344, Q9ULM7
      Related
      ENSP00000264819.3, ENST00000264819.7
      Conserved Domains (3) summary
      smart00717
      Location:301 → 347
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:302 → 346
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:197 → 247
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      305573..344796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438972.1 → XP_047294928.1  mesoderm induction early response protein 2 isoform X5

    2. XM_047438970.1 → XP_047294926.1  mesoderm induction early response protein 2 isoform X2

    3. XM_047438978.1 → XP_047294934.1  mesoderm induction early response protein 2 isoform X5

    4. XM_006722769.5 → XP_006722832.1  mesoderm induction early response protein 2 isoform X4

      Conserved Domains (3) summary
      smart00717
      Location:303 → 349
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:304 → 348
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199 → 249
      ELM2; ELM2 domain

    5. XM_047438971.1 → XP_047294927.1  mesoderm induction early response protein 2 isoform X3

    6. XM_047438969.1 → XP_047294925.1  mesoderm induction early response protein 2 isoform X1

    7. XM_047438977.1 → XP_047294933.1  mesoderm induction early response protein 2 isoform X5

    8. XM_047438976.1 → XP_047294932.1  mesoderm induction early response protein 2 isoform X5

    9. XM_047438975.1 → XP_047294931.1  mesoderm induction early response protein 2 isoform X5

    10. XM_047438974.1 → XP_047294930.1  mesoderm induction early response protein 2 isoform X5

    11. XM_047438973.1 → XP_047294929.1  mesoderm induction early response protein 2 isoform X5

    12. XM_047438979.1 → XP_047294935.1  mesoderm induction early response protein 2 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      255525..294230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321266.1 → XP_054177241.1  mesoderm induction early response protein 2 isoform X4

    2. XM_054321267.1 → XP_054177242.1  mesoderm induction early response protein 2 isoform X5

    3. XM_054321264.1 → XP_054177239.1  mesoderm induction early response protein 2 isoform X2

    4. XM_054321272.1 → XP_054177247.1  mesoderm induction early response protein 2 isoform X5

    5. XM_054321265.1 → XP_054177240.1  mesoderm induction early response protein 2 isoform X3

    6. XM_054321263.1 → XP_054177238.1  mesoderm induction early response protein 2 isoform X1

    7. XM_054321271.1 → XP_054177246.1  mesoderm induction early response protein 2 isoform X5

    8. XM_054321270.1 → XP_054177245.1  mesoderm induction early response protein 2 isoform X5

    9. XM_054321269.1 → XP_054177244.1  mesoderm induction early response protein 2 isoform X5

    10. XM_054321268.1 → XP_054177243.1  mesoderm induction early response protein 2 isoform X5

    11. XM_054321273.1 → XP_054177248.1  mesoderm induction early response protein 2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N344.2 GenPept UniProtKB/Swiss-Prot:Q8N344

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