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    DUSP16 dual specificity phosphatase 16 [ Homo sapiens (human) ]

    Gene ID: 80824, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DUSP16provided by HGNC
    Official Full Name
    dual specificity phosphatase 16provided by HGNC
    Primary source
    HGNC:HGNC:17909
    See related
    Ensembl:ENSG00000111266 MIM:607175; AllianceGenome:HGNC:17909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKP7; MKP-7
    Summary
    This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 19.6), liver (RPKM 13.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP16 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12473282..12562863, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12342454..12456119, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12626216..12715797, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:12509797-12510475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6011 Neighboring gene loss of heterozygosity on chromosome 12, region 2 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene Sharpr-MPRA regulatory region 10643 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12560630-12560819 Neighboring gene Sharpr-MPRA regulatory region 7135 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:12592110-12593309 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25257 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:12610012-12610690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:12686984-12687949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:12688131-12688632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4258 Neighboring gene uncharacterized LOC107984486 Neighboring gene ribosomal protein L19 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6014 Neighboring gene NANOG hESC enhancer GRCh37_chr12:12737991-12738492

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding. Shillingford S, et al. J Biol Chem, 2022 Dec. PMID 36272649, Free PMC Article
    2. DUSP16 ablation arrests the cell cycle and induces cellular senescence. Zhang H, et al. FEBS J, 2015 Dec. PMID 26381291
    3. MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1. Nizamutdinova IT, et al. Cell Signal, 2012 Apr. PMID 22182512
    4. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Masuda K, et al. Biochem Biophys Res Commun, 2010 Mar 5. PMID 20122898
    5. Phosphorylation of Ser-446 determines stability of MKP-7. Katagiri C, et al. J Biol Chem, 2005 Apr 15. PMID 15689616

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.
      Title: A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.
    2. CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.
      Title: CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.
    3. DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo.
      Title: DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo.
    4. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death.
      Title: DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death.
    5. Chemotherapy increased DUSP9 expression and decreased DUSP16 expression in a HIF1-dependent manner.
      Title: Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment.
    6. The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported.
      Title: A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation.
    7. The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci.
      Title: DUSP16 ablation arrests the cell cycle and induces cellular senescence.
    8. analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha
      Title: Structural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solution.
    9. PPARdelta-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK signaling.
      Title: PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.
    10. Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system.
      Title: A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of dual specificity phosphatase 16 (DUSP16) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36298, FLJ40991, KIAA1700, MGC129701, MGC129702

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitogen-activated protein kinase p38 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein carrier chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 16
    Names
    MAP kinase phosphatase 7
    MAPK phosphatase-7
    mitogen-activated protein kinase phosphatase 7
    NP_085143.1
    XP_006719218.1
    XP_011519158.1
    XP_047285524.1
    XP_047285525.1
    XP_047285526.1
    XP_047285527.1
    XP_054187675.1
    XP_054187676.1
    XP_054187677.1
    XP_054187678.1
    XP_054187679.1
    XP_054187680.1
    XP_054187681.1
    XP_054187682.1
    XP_054187683.1
    XP_054229273.1
    XP_054229274.1
    XP_054229275.1
    XP_054229276.1
    XP_054229277.1
    XP_054229278.1
    XP_054229279.1
    XP_054229280.1
    XP_054229281.1
    XP_054229282.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021402.2 RefSeqGene

      Range
      4652..94233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030640.3 → NP_085143.1  dual specificity protein phosphatase 16

      See identical proteins and their annotated locations for NP_085143.1

      Status: REVIEWED

      Source sequence(s)
      AC007619, AC092824, AF506796, DB094627
      Consensus CDS
      CCDS8650.1
      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3
      UniProtKB/TrEMBL
      Q32MA0, Q96N49
      Related
      ENSP00000298573.5, ENST00000298573.9
      Conserved Domains (3) summary
      COG2453
      Location:207 → 300
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:158 → 295
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12473282..12562863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429568.1 → XP_047285524.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    2. XM_047429570.1 → XP_047285526.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    3. XM_006719155.3 → XP_006719218.1  dual specificity protein phosphatase 16 isoform X1

      See identical proteins and their annotated locations for XP_006719218.1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3
      UniProtKB/TrEMBL
      Q32MA0, Q96N49
      Conserved Domains (3) summary
      COG2453
      Location:207 → 300
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:158 → 295
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    4. XM_011520856.2 → XP_011519158.1  dual specificity protein phosphatase 16 isoform X1

      See identical proteins and their annotated locations for XP_011519158.1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3
      UniProtKB/TrEMBL
      Q32MA0, Q96N49
      Conserved Domains (3) summary
      COG2453
      Location:207 → 300
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:158 → 295
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    5. XM_047429569.1 → XP_047285525.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    6. XM_047429571.1 → XP_047285527.1  dual specificity protein phosphatase 16 isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332696.1 Reference GRCh38.p14 PATCHES

      Range
      442285..531866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331700.1 → XP_054187675.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    2. XM_054331705.1 → XP_054187680.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    3. XM_054331702.1 → XP_054187677.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    4. XM_054331701.1 → XP_054187676.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    5. XM_054331703.1 → XP_054187678.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    6. XM_054331706.1 → XP_054187681.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    7. XM_054331704.1 → XP_054187679.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    8. XM_054331707.1 → XP_054187682.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    9. XM_054331708.1 → XP_054187683.1  dual specificity protein phosphatase 16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12342454..12456119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373306.1 → XP_054229281.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    2. XM_054373298.1 → XP_054229273.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    3. XM_054373303.1 → XP_054229278.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    4. XM_054373300.1 → XP_054229275.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    5. XM_054373299.1 → XP_054229274.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    6. XM_054373301.1 → XP_054229276.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    7. XM_054373304.1 → XP_054229279.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    8. XM_054373302.1 → XP_054229277.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    9. XM_054373305.1 → XP_054229280.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q547C7, Q96QS2, Q9BY84, Q9C0G3

    10. XM_054373307.1 → XP_054229282.1  dual specificity protein phosphatase 16 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BY84.1 GenPept UniProtKB/Swiss-Prot:Q9BY84

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