ZNF503 zinc finger protein 503 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF503provided by HGNC
Official Full Name: zinc finger protein 503provided by HGNC
Primary source: HGNC:HGNC:23589
See related: Ensembl:ENSG00000165655 MIM:613902; AllianceGenome:HGNC:23589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Nlz2; NOLZ1; NOLZ-1
Summary: Predicted to enable metal ion binding activity. Involved in G1 to G0 transition involved in cell differentiation; negative regulation of cell population proliferation; and negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney (RPKM 5.4), prostate (RPKM 1.9) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (75279725..75401916, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (76153243..76275966, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (77039483..77161674, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF503 combined with GATA3 is a prognostic factor in triple-negative breast cancer.
Title: ZNF503 combined with GATA3 is a prognostic factor in triple-negative breast cancer.
miR-340-5p inhibits NCI-H1650 cell proliferation and invasion by directly targeting ZNF503 and that miR-340-5p can serve as a potential therapeutic target for treating non-small cell lung cancer.
Title: MicroRNA-340-5p suppresses non-small cell lung cancer cell growth and metastasis by targeting ZNF503.
Long non-coding RNA ZNF503-AS1 promotes retinal pigment epithelial cells differentiation by downregulating ZNF503 expression.
Title: LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression.
We have identified ZPO2 as a negative regulator of GATA3, thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development.
Title: ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1 to G0 transition involved in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 503

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032772.6 → NP_116161.2 zinc finger protein 503

See identical proteins and their annotated locations for NP_116161.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.

Source sequence(s)

AC010997, AI701640, BC011625, BQ574961

Consensus CDS

CCDS7350.1

UniProtKB/Swiss-Prot

Q8NAC5, Q96E25, Q96F45, Q96IJ0

UniProtKB/TrEMBL

A8K2P6

Related

ENSP00000361602.4, ENST00000372524.5

Conserved Domains (2) summary

sd00017
Location:516 → 542

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12402
Location:355 → 415

nlz1; NocA-like zinc-finger protein 1

RNA

NR_120651.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and contains three alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC010997, AI522172, BX105802