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    HIVEP3 HIVEP zinc finger 3 [ Homo sapiens (human) ]

    Gene ID: 59269, updated on 27-Nov-2024

    Summary

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    Official Symbol
    HIVEP3provided by HGNC
    Official Full Name
    HIVEP zinc finger 3provided by HGNC
    Primary source
    HGNC:HGNC:13561
    See related
    Ensembl:ENSG00000127124 MIM:606649; AllianceGenome:HGNC:13561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRC; KBP1; SHN3; ZAS3; KBP-1; ZNF40C; Schnurri-3
    Summary
    This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in skin (RPKM 2.3), brain (RPKM 1.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HIVEP3 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (41506365..42035934, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (41376570..41906502, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41972036..42501605, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41942603-41943309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41947626-41948612 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:41951461-41952660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41959702-41960232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41961826-41962374 Neighboring gene RNA, 5S ribosomal pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41968132-41968632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41978699-41979199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41987015-41987609 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:42006631-42006845 Neighboring gene vir like m6A methyltransferase associated pseudogene Neighboring gene endothelin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 869 Neighboring gene uncharacterized LOC128125817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42136496-42137086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42138269-42138858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42156217-42156717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42198929-42199430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 886 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:42289027-42289544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 754 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:42353785-42353994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 890 Neighboring gene Sharpr-MPRA regulatory region 8090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 755 Neighboring gene uncharacterized LOC124904160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 756 Neighboring gene uncharacterized LOC124904161 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia. Tang Y, et al. Growth Factors, 2023 Feb. PMID 36571205
    2. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Hicar MD, et al. Genomics, 2001 Jan 1. PMID 11161801
    3. HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia. Zhang X, et al. Cancer Med, 2022 Dec. PMID 35535739, Free PMC Article
    4. ZAS3 accentuates transforming growth factor β signaling in epithelial cells. Yakovich AJ, et al. Cell Signal, 2011 Jan. PMID 20732416, Free PMC Article
    5. ZAS3 represses NFκB-dependent transcription by direct competition for DNA binding. Hong JW, et al. BMB Rep, 2010 Dec. PMID 21189157

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia.
      Title: HIVEP3 as a potential prognostic factor promotes the development of acute myeloid leukemia.
    2. HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.
      Title: HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.
    3. The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.
      Title: The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.
    4. rheumatoid arthritis-fibroblast-like synoviocytes were more sensitive to the synergistic increase of Schnurri-3 expression.
      Title: Increased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation.
    5. Transdifferentiation of VSMC into calcifying vascular cells is enhanced by LPC and attenuated by Schnurri-3.
      Title: Effect of lyso-phosphatidylcholine and Schnurri-3 on osteogenic transdifferentiation of vascular smooth muscle cells to calcifying vascular cells in 3D culture.
    6. ZAS3 expression is directly regulated by estrogen and is overexpressed in lupus. Its upregulation by estrogen could play a critical role in female-biased autoimmune disorders.
      Title: Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.
    7. The inhibitory effect of ZAS3 on NF-kappa B activity is mediated by neither direct association with N-kappa B nor disrupting nuclear localization of NFvarkappaB.
      Title: ZAS3 promotes TNFα-induced apoptosis by blocking NFϰB-activated expression of the anti-apoptotic genes TRAF1 and TRAF2.
    8. DNA competition by ZAS3 is sufficient to repress transcription activated by NF-kappaB and that ZAS3 is an endogenous kappaB-motif competitor with ininsic repression activity.
      Title: ZAS3 represses NFκB-dependent transcription by direct competition for DNA binding.
    9. An interaction between ZAS3 and Smad proteins enhances transforming growth factor beta signaling.
      Title: ZAS3 accentuates transforming growth factor β signaling in epithelial cells.
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-01-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    EBI GWAS Catalog
    Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16752, KIAA1555

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor HIVEP3
    Names
    ZAS family, member 3
    human immunodeficiency virus type I enhancer binding protein 3
    kappa-B and V(D)J recombination signal sequences-binding protein
    kappa-binding protein 1
    zinc finger protein ZAS3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030026.2 RefSeqGene

      Range
      122004..534561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127714.3 → NP_001121186.1  transcription factor HIVEP3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC105268, AC119676, AI082114, AL445933, BC152563
      Consensus CDS
      CCDS44124.1
      UniProtKB/Swiss-Prot
      Q5T1R4
      Related
      ENSP00000361665.1, ENST00000372584.5
      Conserved Domains (3) summary
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1754 → 1776
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    2. NM_024503.5 → NP_078779.2  transcription factor HIVEP3 isoform a

      See identical proteins and their annotated locations for NP_078779.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105268, AF278765, AI082114, AL445933, BC152563
      Consensus CDS
      CCDS463.1
      UniProtKB/Swiss-Prot
      A7YY91, Q5T1R4, Q5T1R5, Q9BZS0, Q9HCL7
      Related
      ENSP00000361664.1, ENST00000372583.6
      Conserved Domains (4) summary
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1754 → 1776
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain
      cl26464
      Location:1877 → 2395
      Atrophin-1; Atrophin-1 family

    RNA

    1. NR_038260.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks all but the first exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC105268, BC040942, BG213993, DA093318
      Related
      ENST00000491442.5

    2. NR_038261.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks all but the first exon, and contains an alternate 5' and two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AL158216, BC046120, BG213993
      Related
      ENST00000489103.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      41506365..42035934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426877.1 → XP_047282833.1  transcription factor HIVEP3 isoform X4

    2. XM_047426875.1 → XP_047282831.1  transcription factor HIVEP3 isoform X1

    3. XM_011541885.4 → XP_011540187.1  transcription factor HIVEP3 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011541887.4 → XP_011540189.1  transcription factor HIVEP3 isoform X5

      Conserved Domains (2) summary
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011541886.4 → XP_011540188.1  transcription factor HIVEP3 isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_007062478.1 RNA Sequence

    2. XR_007062479.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      41376570..41906502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338008.1 → XP_054193983.1  transcription factor HIVEP3 isoform X4

    2. XM_054338005.1 → XP_054193980.1  transcription factor HIVEP3 isoform X1

    3. XM_054338006.1 → XP_054193981.1  transcription factor HIVEP3 isoform X2

    4. XM_054338009.1 → XP_054193984.1  transcription factor HIVEP3 isoform X5

    5. XM_054338007.1 → XP_054193982.1  transcription factor HIVEP3 isoform X3

    RNA

    1. XR_008486133.1 RNA Sequence

    2. XR_008486134.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T1R4.1 GenPept UniProtKB/Swiss-Prot:Q5T1R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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