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    PROKR2 prokineticin receptor 2 [ Homo sapiens (human) ]

    Gene ID: 128674, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PROKR2provided by HGNC
    Official Full Name
    prokineticin receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:15836
    See related
    Ensembl:ENSG00000101292 MIM:607123; AllianceGenome:HGNC:15836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3
    Summary
    Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See PROKR2 in Genome Data Viewer
    Location:
    20p12.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (5299218..5316954, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (5339785..5357889, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5279864..5297600, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:5107325-5107826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113215-5113716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113717-5114216 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5150939-5151438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17515 Neighboring gene Sharpr-MPRA regulatory region 2649 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:5156307-5156942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17517 Neighboring gene meiotic recombination hotspot R Neighboring gene OCT4 hESC enhancer GRCh37_chr20:5246300-5246801 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 1 Neighboring gene RNA, 5.8S ribosomal pseudogene 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:5376502-5377701 Neighboring gene reporter assay-validated silencer 4 Neighboring gene long intergenic non-protein coding RNA 658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency. Kardelen AD, et al. J Clin Res Pediatr Endocrinol, 2023 Nov 22. PMID 37338295, Free PMC Article
    2. Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. Kishi T, et al. Neuromolecular Med, 2009. PMID 19544013
    3. PROKR2 is associated with methamphetamine dependence in the Japanese population. Kishi T, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 Aug 16. PMID 20576534
    4. Evidence that prokineticin receptor 2 exists as a dimer in vivo. Marsango S, et al. Cell Mol Life Sci, 2011 Sep. PMID 21161321, Free PMC Article
    5. Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking. Peng Z, et al. J Biol Chem, 2011 May 13. PMID 21454486, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation.
      Title: Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation.
    2. PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.
      Title: PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.
    3. Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.
      Title: Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.
    4. A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.
      Title: A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.
    5. Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
      Title: Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
    6. [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].
      Title: [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].
    7. Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.
      Title: Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.
    8. Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.
      Title: Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.
    9. Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
      Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
    10. Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.
      Title: Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    prokineticin receptor 2
    Names
    G protein-coupled receptor 73-like 1
    G-protein coupled receptor I5E
    PK-R2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008132.2 RefSeqGene

      Range
      2638..18170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144773.4 → NP_658986.1  prokineticin receptor 2

      See identical proteins and their annotated locations for NP_658986.1

      Status: REVIEWED

      Source sequence(s)
      AL121755, AL121757
      Consensus CDS
      CCDS13089.1
      UniProtKB/Swiss-Prot
      A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
      UniProtKB/TrEMBL
      A8K1T0
      Related
      ENSP00000504128.1, ENST00000678254.1
      Conserved Domains (1) summary
      cd15204
      Location:54 → 344
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      5299218..5316954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027646.2 → XP_016883135.1  prokineticin receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
      UniProtKB/TrEMBL
      A8K1T0
      Conserved Domains (1) summary
      cd15204
      Location:54 → 344
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      5339785..5357889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322965.1 → XP_054178940.1  prokineticin receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
      UniProtKB/TrEMBL
      A8K1T0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFJ6.1 GenPept UniProtKB/Swiss-Prot:Q8NFJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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