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    KIN Kin17 DNA and RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 22944, updated on 9-Dec-2024

    Summary

    Official Symbol
    KINprovided by HGNC
    Official Full Name
    Kin17 DNA and RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6327
    See related
    Ensembl:ENSG00000151657 MIM:601720; AllianceGenome:HGNC:6327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTCD; Rts2; KIN17
    Summary
    The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in endometrium (RPKM 1.8), thyroid (RPKM 1.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIN in Genome Data Viewer
    Location:
    10p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (7750962..7787993, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (7751725..7788763, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7792925..7829956, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:7677530-7678369 Neighboring gene Sharpr-MPRA regulatory region 2566 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7809082-7809283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2981 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7830681-7831224 Neighboring gene uncharacterized LOC105376392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860144-7860662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860663-7861180 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene Sharpr-MPRA regulatory region 6244 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:8003953-8004117 Neighboring gene Sharpr-MPRA regulatory region 13617

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA/RNA-binding protein KIN17
    Names
    KIN, antigenic determinant of recA protein homolog
    binding to curved DNA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012311.4NP_036443.1  DNA/RNA-binding protein KIN17

      See identical proteins and their annotated locations for NP_036443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AA768850, AJ005273, AK301789, AL158044
      Consensus CDS
      CCDS7080.1
      UniProtKB/Swiss-Prot
      B4DX32, O60870
      Related
      ENSP00000368881.3, ENST00000379562.9
      Conserved Domains (4) summary
      smart00451
      Location:2554
      ZnF_U1; U1-like zinc finger
      cd13155
      Location:339392
      KOW_KIN17; KOW_Kin17 is a RNA-binding motif
      pfam10357
      Location:55177
      Kin17_mid; Domain of Kin17 curved DNA-binding protein
      pfam18131
      Location:276328
      KN17_SH3; KN17 SH3-like C-terminal domain

    RNA

    1. NR_045609.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses alternate exon structure at its 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA768850, AK301789, AL158044

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      7750962..7787993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717435.5XP_006717498.1  DNA/RNA-binding protein KIN17 isoform X2

      UniProtKB/TrEMBL
      B7Z421
      Conserved Domains (2) summary
      pfam10357
      Location:171
      Kin17_mid; Domain of Kin17 curved DNA-binding protein
      cl00354
      Location:233267
      KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
    2. XM_006717434.5XP_006717497.1  DNA/RNA-binding protein KIN17 isoform X1

      See identical proteins and their annotated locations for XP_006717497.1

      Conserved Domains (2) summary
      pfam10357
      Location:55177
      Kin17_mid; Domain of Kin17 curved DNA-binding protein
      cl00354
      Location:339373
      KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)

    RNA

    1. XR_930485.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      7751725..7788763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365236.1XP_054221211.1  DNA/RNA-binding protein KIN17 isoform X1

    2. XM_054365237.1XP_054221212.1  DNA/RNA-binding protein KIN17 isoform X2

      UniProtKB/TrEMBL
      B7Z421

    RNA

    1. XR_008488183.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045610.1: Suppressed sequence

      Description
      NR_045610.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3'' end.