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    PUS9 pseudouridine synthase PUS9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851525, updated on 29-Jun-2024

    Summary

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    Gene symbol
    PUS9
    Gene description
    pseudouridine synthase PUS9
    Primary source
    FungiDB:YDL036C
    Locus tag
    YDL036C
    See related
    SGD:S000002194; AllianceGenome:SGD:S000002194; VEuPathDB:YDL036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pseudouridine synthase activity. Involved in tRNA pseudouridine synthesis. Located in mitochondrion. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PUS9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (387513..388901, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM7 Neighboring gene Bsc1p Neighboring gene Gpr1p Neighboring gene tRNA-5-taurinomethyluridine 2-sulfurtransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. Behm-Ansmant I, et al. J Biol Chem, 2004 Dec 17. PMID 15466869
    2. An investigation into eukaryotic pseudouridine synthases. King RD, et al. J Bioinform Comput Biol, 2014 Aug. PMID 25152040
    3. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Carlile TM, et al. Nature, 2014 Nov 6. PMID 25192136, Free PMC Article
    4. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Schwartz S, et al. Cell, 2014 Sep 25. PMID 25219674, Free PMC Article
    5. Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. Mitchell L, et al. PLoS One, 2011. PMID 21984913, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pus9p is a tRNA:pseudouridine-32 synthase responsible for the modification of mitochondrial tRNAs. [PUS9]
      Title: Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA pseudouridine(32) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    pseudouridine synthase PUS9
    NP_010248.1
    • Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      387513..388901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180095.1 → NP_010248.1  TPA: pseudouridine synthase PUS9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010248.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRV8, Q12069, Q6B2P8
      UniProtKB/TrEMBL
      A0A8H8UMP3, B3LGT7, C8Z4N2
      Conserved Domains (1) summary
      TIGR00005
      Location:121 → 433
      rluA_subfam; pseudouridine synthase, RluA family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12069.1

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