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    PTGIR prostaglandin I2 receptor [ Homo sapiens (human) ]

    Gene ID: 5739, updated on 3-Dec-2024

    Summary

    Official Symbol
    PTGIRprovided by HGNC
    Official Full Name
    prostaglandin I2 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9602
    See related
    Ensembl:ENSG00000160013 MIM:600022; AllianceGenome:HGNC:9602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IP; PRIPR
    Summary
    The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 50.8), placenta (RPKM 17.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTGIR in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46610687..46625089, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49436301..49450683, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47123725..47128346, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPP5 tetratricopeptide repeat domain containing 1, pseudogene Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 38 Neighboring gene MPRA-validated peak3525 silencer Neighboring gene MPRA-validated peak3526 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14843 Neighboring gene uncharacterized LOC124904729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14845 Neighboring gene calmodulin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47119779-47120280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47120281-47120780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47124126-47124640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47128561-47129061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10816 Neighboring gene Sharpr-MPRA regulatory region 2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10819 Neighboring gene G protein subunit gamma 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47157789-47158515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10820 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102830

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables prostacyclin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    prostacyclin receptor
    Names
    PGI receptor
    PGI2 receptor
    prostaglandin I2 (prostacyclin) receptor (IP)
    prostanoid IP receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000960.4NP_000951.1  prostacyclin receptor

      See identical proteins and their annotated locations for NP_000951.1

      Status: REVIEWED

      Source sequence(s)
      BQ185457, D25418, DA652875
      Consensus CDS
      CCDS12686.1
      UniProtKB/Swiss-Prot
      P43119
      UniProtKB/TrEMBL
      Q2YD89
      Related
      ENSP00000291294.1, ENST00000291294.7
      Conserved Domains (2) summary
      cd14964
      Location:1640
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:14304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46610687..46625089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259095.5XP_005259152.1  prostacyclin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0B4J2A7
      Conserved Domains (1) summary
      cl21561
      Location:27221
      7tm_4; Olfactory receptor
    2. XM_005259093.4XP_005259150.1  prostacyclin receptor isoform X1

      Conserved Domains (1) summary
      cl21561
      Location:27221
      7tm_4; Olfactory receptor

    RNA

    1. XR_430206.4 RNA Sequence

    2. XR_935844.3 RNA Sequence

    3. XR_243945.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49436301..49450683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321523.1XP_054177498.1  prostacyclin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0B4J2A7
    2. XM_054321522.1XP_054177497.1  prostacyclin receptor isoform X1

    RNA

    1. XR_008485170.1 RNA Sequence

    2. XR_008485169.1 RNA Sequence

    3. XR_008485168.1 RNA Sequence