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    GNG11 G protein subunit gamma 11 [ Homo sapiens (human) ]

    Gene ID: 2791, updated on 9-Dec-2024

    Summary

    Official Symbol
    GNG11provided by HGNC
    Official Full Name
    G protein subunit gamma 11provided by HGNC
    Primary source
    HGNC:HGNC:4403
    See related
    Ensembl:ENSG00000127920 MIM:604390; AllianceGenome:HGNC:4403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG3H1; GNGT11
    Summary
    This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 168.6), placenta (RPKM 159.2) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GNG11 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (93921735..93928610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (95157662..95164537)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93551047..93557922)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene TFPI2 divergent transcript Neighboring gene uncharacterized LOC105375402 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:93543651-93544850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:93550649-93551284 Neighboring gene G protein subunit gamma transducin 1 Neighboring gene BET1 antisense RNA 1 Neighboring gene Bet1 golgi vesicular membrane trafficking protein Neighboring gene ReSE screen-validated silencer GRCh37_chr7:93618399-93618603 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:93632877-93633483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:93633484-93634089 Neighboring gene uncharacterized LOC130890646 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:93689611-93690810

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Names
    G protein gamma-11 subunit
    guanine nucleotide binding protein (G protein), gamma 11
    guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit
    heterotrimeric guanine nucleotide-binding protein 3H1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004126.4NP_004117.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor

      See identical proteins and their annotated locations for NP_004117.1

      Status: REVIEWED

      Source sequence(s)
      AC002076, BC009709
      Consensus CDS
      CCDS5634.1
      UniProtKB/Swiss-Prot
      P50152, P61952
      UniProtKB/TrEMBL
      Q53Y01
      Related
      ENSP00000248564.4, ENST00000248564.6
      Conserved Domains (1) summary
      smart00224
      Location:1273
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      93921735..93928610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      95157662..95164537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)