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    ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 25820, updated on 9-Dec-2024

    Summary

    Official Symbol
    ARIH1provided by HGNC
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:689
    See related
    Ensembl:ENSG00000166233 MIM:605624; AllianceGenome:HGNC:689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARI; HARI; HHARI; UBCH7BP
    Summary
    Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in several cellular components, including Lewy body; cullin-RING ubiquitin ligase complex; and nuclear body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARIH1 in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72474330..72602987)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70291593..70420271)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72766671..72895328)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TMEM202 antisense RNA 1 Neighboring gene transmembrane protein 202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:72743763-72744262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9722 Neighboring gene PHB1 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9723 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:72766566-72766762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6625 Neighboring gene MPRA-validated peak2380 silencer Neighboring gene SWI5 recombination repair homolog (yeast) pseudogene Neighboring gene microRNA 630 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72902139-72902639 Neighboring gene golgin A6 family member A pseudogene Neighboring gene long intergenic non-protein coding RNA 2259

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20329, FLJ93118, DKFZp686O13120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in PKR/eIFalpha signaling TAS
    Traceable Author Statement
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    NOT part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul4A-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Lewy body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ARIH1
    Names
    ARI-1
    H7-AP2
    MOP-6
    ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
    ariadne, Drosophila, homolog of
    monocyte protein 6
    protein ariadne-1 homolog
    ubcH7-binding protein
    ubcM4-interacting protein
    ubiquitin-conjugating enzyme E2-binding protein 1
    NP_005735.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005744.5NP_005735.2  E3 ubiquitin-protein ligase ARIH1

      See identical proteins and their annotated locations for NP_005735.2

      Status: VALIDATED

      Source sequence(s)
      AC079322, AC100827
      Consensus CDS
      CCDS10244.1
      UniProtKB/Swiss-Prot
      B2R6U3, O76026, Q9H3T6, Q9UEN0, Q9UP39, Q9Y4X5
      Related
      ENSP00000369217.4, ENST00000379887.9
      Conserved Domains (3) summary
      smart00647
      Location:257317
      IBR; In Between Ring fingers
      cd16626
      Location:185242
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:339379
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72474330..72602987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70291593..70420271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)