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    SLC25A37 solute carrier family 25 member 37 [ Homo sapiens (human) ]

    Gene ID: 51312, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC25A37provided by HGNC
    Official Full Name
    solute carrier family 25 member 37provided by HGNC
    Primary source
    HGNC:HGNC:29786
    See related
    Ensembl:ENSG00000147454 MIM:610387; AllianceGenome:HGNC:29786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217
    Summary
    SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
    Expression
    Broad expression in bone marrow (RPKM 58.8), duodenum (RPKM 28.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC25A37 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (23528956..23575463)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (23803825..23850325)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23386469..23432976)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ENTPD4 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23339113-23340081 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 pseudogene Neighboring gene uncharacterized LOC105379327 Neighboring gene CRISPRi-validated cis-regulatory element chr8.847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23399784-23400565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23407857-23408358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19028 Neighboring gene RNA, U4 small nuclear 71, pseudogene Neighboring gene SINHCAF pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hemoglobin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitoferrin-1
    Names
    mitochondrial iron transporter 1
    mitochondrial solute carrier protein
    mitoferrin
    predicted protein of HQ2217
    solute carrier family 25 (mitochondrial iron transporter), member 37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317812.2NP_001304741.1  mitoferrin-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC051642
      UniProtKB/Swiss-Prot
      Q9NYZ2
      UniProtKB/TrEMBL
      Q71JB2
      Conserved Domains (1) summary
      pfam00153
      Location:173
      Mito_carr; Mitochondrial carrier protein
    2. NM_001317813.2NP_001304742.1  mitoferrin-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC051642
      UniProtKB/Swiss-Prot
      Q9NYZ2
      UniProtKB/TrEMBL
      Q71JB2
      Conserved Domains (1) summary
      pfam00153
      Location:70152
      Mito_carr; Mitochondrial carrier protein
    3. NM_001317814.2NP_001304743.1  mitoferrin-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC051642
      UniProtKB/Swiss-Prot
      Q9NYZ2
      UniProtKB/TrEMBL
      Q71JB2
      Conserved Domains (1) summary
      pfam00153
      Location:70152
      Mito_carr; Mitochondrial carrier protein
    4. NM_016612.4NP_057696.2  mitoferrin-1 isoform 1

      See identical proteins and their annotated locations for NP_057696.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC051642
      Consensus CDS
      CCDS47828.1
      UniProtKB/Swiss-Prot
      A2RU93, Q53FT7, Q69YJ8, Q969S1, Q9NYZ2, Q9P0J2
      Related
      ENSP00000429200.1, ENST00000519973.6
      Conserved Domains (1) summary
      pfam00153
      Location:44136
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      23528956..23575463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544550.3XP_011542852.1  mitoferrin-1 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:76158
      Mito_carr; Mitochondrial carrier protein
    2. XM_006716352.4XP_006716415.1  mitoferrin-1 isoform X2

      See identical proteins and their annotated locations for XP_006716415.1

      Conserved Domains (1) summary
      pfam00153
      Location:70152
      Mito_carr; Mitochondrial carrier protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      23803825..23850325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360621.1XP_054216596.1  mitoferrin-1 isoform X1

    2. XM_054360622.1XP_054216597.1  mitoferrin-1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018579.2: Suppressed sequence

      Description
      NM_018579.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    2. NM_018586.1: Suppressed sequence

      Description
      NM_018586.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.