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    PARP6 poly(ADP-ribose) polymerase family member 6 [ Homo sapiens (human) ]

    Gene ID: 56965, updated on 3-Dec-2024

    Summary

    Official Symbol
    PARP6provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase family member 6provided by HGNC
    Primary source
    HGNC:HGNC:26921
    See related
    Ensembl:ENSG00000137817 MIM:619439; AllianceGenome:HGNC:26921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTD17; pART17; PARP-6-C; PARP-6-B1
    Summary
    Enables NAD+-protein-aspartate ADP-ribosyltransferase activity and NAD+-protein-cysteine ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 26.3), thyroid (RPKM 13.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PARP6 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72241181..72272554, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70057855..70089700, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72533522..72564895, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903522 Neighboring gene Sharpr-MPRA regulatory region 4122 Neighboring gene GRAM domain containing 2A Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:72485963-72486586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6617 Neighboring gene pyruvate kinase M1/2 Neighboring gene Sharpr-MPRA regulatory region 1213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6619 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:72529434-72530633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9718 Neighboring gene uncharacterized LOC105370887 Neighboring gene CUGBP Elav-like family member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6621

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC131971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein-cysteine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein auto-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP6
    Names
    ADP-ribosyltransferase diphtheria toxin-like 17
    MIEREN, class I
    MIEREN, class II
    PARP-6
    poly [ADP-ribose] polymerase 6
    NP_001310444.1
    NP_001310445.1
    NP_001310448.1
    NP_001310450.1
    NP_001310451.1
    NP_001310452.1
    NP_001310453.1
    NP_001310454.1
    NP_001310455.1
    NP_001310457.1
    NP_001310459.1
    NP_001310460.1
    NP_001310461.1
    NP_064599.2
    XP_011520107.1
    XP_047288829.1
    XP_047288830.1
    XP_047288831.1
    XP_047288832.1
    XP_047288833.1
    XP_054234446.1
    XP_054234447.1
    XP_054234448.1
    XP_054234449.1
    XP_054234450.1
    XP_054234451.1
    XP_054234452.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323515.2NP_001310444.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Related
      ENSP00000455815.1, ENST00000567974.5
      Conserved Domains (1) summary
      cd01341
      Location:451575
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    2. NM_001323516.2NP_001310445.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:451575
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    3. NM_001323519.2NP_001310448.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:450574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    4. NM_001323521.2NP_001310450.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:450574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    5. NM_001323522.2NP_001310451.1  protein mono-ADP-ribosyltransferase PARP6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009690
      Consensus CDS
      CCDS10241.2
      UniProtKB/Swiss-Prot
      Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:470594
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    6. NM_001323523.2NP_001310452.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:450574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    7. NM_001323524.2NP_001310453.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:450574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    8. NM_001323525.2NP_001310454.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:471595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    9. NM_001323526.2NP_001310455.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:450574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    10. NM_001323528.2NP_001310457.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:471595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    11. NM_001323530.2NP_001310459.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:451575
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    12. NM_001323531.2NP_001310460.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC009690
      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:471595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    13. NM_001323532.2NP_001310461.1  protein mono-ADP-ribosyltransferase PARP6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009690
      Consensus CDS
      CCDS10241.2
      UniProtKB/Swiss-Prot
      Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
      UniProtKB/TrEMBL
      A0PJ50
      Related
      ENSP00000456348.1, ENST00000569795.6
      Conserved Domains (1) summary
      cd01341
      Location:470594
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    14. NM_020214.4NP_064599.2  protein mono-ADP-ribosyltransferase PARP6 isoform 1

      See identical proteins and their annotated locations for NP_064599.2

      Status: VALIDATED

      Source sequence(s)
      AC009690
      Consensus CDS
      CCDS10241.2
      UniProtKB/Swiss-Prot
      Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
      UniProtKB/TrEMBL
      A0PJ50
      Related
      ENSP00000287196.9, ENST00000287196.13
      Conserved Domains (1) summary
      cd01341
      Location:470594
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    RNA

    1. NR_136594.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    2. NR_136596.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    3. NR_136599.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    4. NR_136603.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    5. NR_136604.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    6. NR_136605.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
      Related
      ENST00000567440.5
    7. NR_136606.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    8. NR_136607.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    9. NR_136608.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    10. NR_136609.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    11. NR_136610.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690
    12. NR_136611.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009690

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72241181..72272554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432874.1XP_047288830.1  protein mono-ADP-ribosyltransferase PARP6 isoform X2

      UniProtKB/Swiss-Prot
      Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
      UniProtKB/TrEMBL
      A0PJ50
    2. XM_047432873.1XP_047288829.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      A0PJ50
    3. XM_011521805.3XP_011520107.1  protein mono-ADP-ribosyltransferase PARP6 isoform X6

      See identical proteins and their annotated locations for XP_011520107.1

      UniProtKB/TrEMBL
      A0PJ50
      Conserved Domains (1) summary
      cd01341
      Location:336460
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    4. XM_047432877.1XP_047288833.1  protein mono-ADP-ribosyltransferase PARP6 isoform X5

      UniProtKB/TrEMBL
      H3BRZ3
      Related
      ENSP00000456468.1, ENST00000564610.5
    5. XM_047432876.1XP_047288832.1  protein mono-ADP-ribosyltransferase PARP6 isoform X4

      UniProtKB/TrEMBL
      H3BRZ3, J7MDH3
      Related
      ENSP00000260376.7, ENST00000260376.11
      Conserved Domains (2) summary
      cd01341
      Location:222358
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
      cl00283
      Location:470497
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    6. XM_047432875.1XP_047288831.1  protein mono-ADP-ribosyltransferase PARP6 isoform X3

      UniProtKB/TrEMBL
      F5H3B4, H3BRR4
      Related
      ENSP00000456370.1, ENST00000565443.5

    RNA

    1. XR_007064475.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70057855..70089700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378472.1XP_054234447.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      A0PJ50
    2. XM_054378473.1XP_054234448.1  protein mono-ADP-ribosyltransferase PARP6 isoform X2

      UniProtKB/Swiss-Prot
      Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
      UniProtKB/TrEMBL
      A0PJ50
    3. XM_054378471.1XP_054234446.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      A0PJ50
    4. XM_054378477.1XP_054234452.1  protein mono-ADP-ribosyltransferase PARP6 isoform X6

      UniProtKB/TrEMBL
      A0PJ50
    5. XM_054378476.1XP_054234451.1  protein mono-ADP-ribosyltransferase PARP6 isoform X5

      UniProtKB/TrEMBL
      H3BRZ3
    6. XM_054378475.1XP_054234450.1  protein mono-ADP-ribosyltransferase PARP6 isoform X4

      UniProtKB/TrEMBL
      H3BRZ3, J7MDH3
    7. XM_054378474.1XP_054234449.1  protein mono-ADP-ribosyltransferase PARP6 isoform X3

      UniProtKB/TrEMBL
      F5H3B4, H3BRR4

    RNA

    1. XR_008488995.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020213.1: Suppressed sequence

      Description
      NM_020213.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.