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    ART3 ADP-ribosyltransferase 3 (inactive) [ Homo sapiens (human) ]

    Gene ID: 419, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ART3provided by HGNC
    Official Full Name
    ADP-ribosyltransferase 3 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:725
    See related
    Ensembl:ENSG00000156219 MIM:603086; AllianceGenome:HGNC:725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTC3
    Summary
    This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See ART3 in Genome Data Viewer
    Location:
    4q21.1; 4p15.1-p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (76011190..76112786)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79351693..79453452)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76932343..77033939)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76932273-76932917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76938237-76938736 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene ribosomal protein L36 pseudogene 8 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77016693-77017194 Neighboring gene nucleoporin 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21626 Neighboring gene uncharacterized LOC124900718 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77075501-77076330 Neighboring gene scavenger receptor class B member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. Tan L, et al. Oncotarget, 2016 Jul 19. PMID 27374177, Free PMC Article
    2. Selective expression of RT6 superfamily in human bronchial epithelial cells. Balducci E, et al. Am J Respir Cell Mol Biol, 1999 Sep. PMID 10460751
    3. Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Grahnert A, et al. Biochem J, 2002 Mar 15. PMID 11879200, Free PMC Article
    4. Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. Friedrich M, et al. Asian J Androl, 2006 May. PMID 16625277
    5. Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. Okada H, et al. PLoS Genet, 2008 Feb. PMID 18266473, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knockdown of ART3 in breast cancer cells inhibited cell proliferation and invasion.
      Title: ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. genome-wide gene expression analyses were used to identify genes involved in the pathogenesis of non-obstructive azoospermia, and ART3 was subsequently identified as a susceptibility gene
      Title: Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    6. ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis.
      Title: Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.
    7. ART3 expression appears to be governed by a combination of differential splicing and tissue-preferential use of two alternative promoters.
      Title: Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26404

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 3
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 3
    NAD(P)(+)--arginine ADP-ribosyltransferase 3
    mono(ADP-ribosyl)transferase 3
    mono-ADP-ribosyltransferase
    NP_001123488.1
    NP_001123489.1
    NP_001170.2
    NP_001364102.1
    NP_001364103.1
    NP_001364104.1
    NP_001364105.1
    NP_001364106.1
    NP_001364107.1
    NP_001364108.1
    NP_001364109.1
    NP_001364110.1
    NP_001364111.1
    NP_001364112.1
    NP_001364113.1
    NP_001364114.1
    XP_016863695.1
    XP_024309818.1
    XP_024309819.1
    XP_024309820.1
    XP_024309821.1
    XP_024309822.1
    XP_024309824.1
    XP_024309826.1
    XP_024309827.1
    XP_024309829.1
    XP_024309830.1
    XP_024309831.1
    XP_047271651.1
    XP_047271652.1
    XP_047271653.1
    XP_047271654.1
    XP_047271655.1
    XP_047271656.1
    XP_054206006.1
    XP_054206007.1
    XP_054206008.1
    XP_054206009.1
    XP_054206010.1
    XP_054206011.1
    XP_054206012.1
    XP_054206013.1
    XP_054206014.1
    XP_054206015.1
    XP_054206016.1
    XP_054206017.1
    XP_054206018.1
    XP_054206019.1
    XP_054206020.1
    XP_054206021.1
    XP_054206022.1
    XP_054206023.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130016.3 → NP_001123488.1  ecto-ADP-ribosyltransferase 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001123488.1

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47079.1
      UniProtKB/Swiss-Prot
      Q13508, Q53XW3, Q6FHT7, Q8WVJ7, Q93069, Q96HL1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000348064.4, ENST00000355810.9
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    2. NM_001130017.3 → NP_001123489.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

      See identical proteins and their annotated locations for NP_001123489.1

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47080.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000343843.5, ENST00000341029.9
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    3. NM_001179.6 → NP_001170.2  ecto-ADP-ribosyltransferase 3 isoform b precursor

      See identical proteins and their annotated locations for NP_001170.2

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS3575.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000304313.5, ENST00000349321.7
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    4. NM_001377173.1 → NP_001364102.1  ecto-ADP-ribosyltransferase 3 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS93546.1
      UniProtKB/TrEMBL
      H0Y8V6
      Related
      ENSP00000422249.2, ENST00000511188.2
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    5. NM_001377174.1 → NP_001364103.1  ecto-ADP-ribosyltransferase 3 isoform l precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    6. NM_001377175.1 → NP_001364104.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      Consensus CDS
      CCDS47080.1
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    7. NM_001377176.1 → NP_001364105.1  ecto-ADP-ribosyltransferase 3 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    8. NM_001377177.1 → NP_001364106.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    9. NM_001377178.1 → NP_001364107.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    10. NM_001377179.1 → NP_001364108.1  ecto-ADP-ribosyltransferase 3 isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    11. NM_001377180.1 → NP_001364109.1  ecto-ADP-ribosyltransferase 3 isoform h precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    12. NM_001377181.1 → NP_001364110.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    13. NM_001377182.1 → NP_001364111.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    14. NM_001377183.1 → NP_001364112.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    15. NM_001377184.1 → NP_001364113.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    16. NM_001377185.1 → NP_001364114.1  ecto-ADP-ribosyltransferase 3 isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      AC112719
      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      76011190..76112786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415697.1 → XP_047271653.1  ecto-ADP-ribosyltransferase 3 isoform X7

    2. XM_047415700.1 → XP_047271656.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    3. XM_047415695.1 → XP_047271651.1  ecto-ADP-ribosyltransferase 3 isoform X4

    4. XM_047415696.1 → XP_047271652.1  ecto-ADP-ribosyltransferase 3 isoform X7

    5. XM_047415699.1 → XP_047271655.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    6. XM_047415698.1 → XP_047271654.1  ecto-ADP-ribosyltransferase 3 isoform X7

    7. XM_024454063.2 → XP_024309831.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    8. XM_024454053.2 → XP_024309821.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    9. XM_024454052.2 → XP_024309820.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    10. XM_017008206.3 → XP_016863695.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    11. XM_024454051.2 → XP_024309819.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    12. XM_024454062.2 → XP_024309830.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7, A0A8V8TQ78
      Related
      ENSP00000514989.1, ENST00000700440.1
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    13. XM_024454056.2 → XP_024309824.1  ecto-ADP-ribosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    14. XM_024454058.2 → XP_024309826.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    15. XM_024454059.2 → XP_024309827.1  ecto-ADP-ribosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    16. XM_024454061.2 → XP_024309829.1  ecto-ADP-ribosyltransferase 3 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQ78
      Related
      ENSP00000514990.1, ENST00000700441.1
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    17. XM_024454050.2 → XP_024309818.1  ecto-ADP-ribosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    18. XM_024454054.2 → XP_024309822.1  ecto-ADP-ribosyltransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam01129
      Location:29 → 252
      ART; NAD:arginine ADP-ribosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      79351693..79453452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350042.1 → XP_054206017.1  ecto-ADP-ribosyltransferase 3 isoform X7

    2. XM_054350047.1 → XP_054206022.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    3. XM_054350038.1 → XP_054206013.1  ecto-ADP-ribosyltransferase 3 isoform X4

    4. XM_054350041.1 → XP_054206016.1  ecto-ADP-ribosyltransferase 3 isoform X7

    5. XM_054350046.1 → XP_054206021.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    6. XM_054350043.1 → XP_054206018.1  ecto-ADP-ribosyltransferase 3 isoform X7

    7. XM_054350048.1 → XP_054206023.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    8. XM_054350035.1 → XP_054206010.1  ecto-ADP-ribosyltransferase 3 isoform X1

    9. XM_054350032.1 → XP_054206007.1  ecto-ADP-ribosyltransferase 3 isoform X1

    10. XM_054350033.1 → XP_054206008.1  ecto-ADP-ribosyltransferase 3 isoform X1

    11. XM_054350031.1 → XP_054206006.1  ecto-ADP-ribosyltransferase 3 isoform X1

    12. XM_054350045.1 → XP_054206020.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPP7

    13. XM_054350037.1 → XP_054206012.1  ecto-ADP-ribosyltransferase 3 isoform X3

    14. XM_054350039.1 → XP_054206014.1  ecto-ADP-ribosyltransferase 3 isoform X5

    15. XM_054350040.1 → XP_054206015.1  ecto-ADP-ribosyltransferase 3 isoform X6

    16. XM_054350044.1 → XP_054206019.1  ecto-ADP-ribosyltransferase 3 isoform X8

    17. XM_054350034.1 → XP_054206009.1  ecto-ADP-ribosyltransferase 3 isoform X1

    18. XM_054350036.1 → XP_054206011.1  ecto-ADP-ribosyltransferase 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13508.2 GenPept UniProtKB/Swiss-Prot:Q13508

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