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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029679.1 RefSeqGene
- Range
-
4995..51386
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_022462.4 → NP_071907.4 hypoxia-inducible factor 3-alpha isoform b
See identical proteins and their annotated locations for NP_071907.4
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 3. The resulting isoform (b) has a distinct and shorter N-terminus, compared to isoform c.
- Source sequence(s)
-
AC007193, AK297828, BM971722, DC423791
- Consensus CDS
-
CCDS42580.2
- UniProtKB/TrEMBL
-
B4DSD9
- Related
- ENSP00000244303.6, ENST00000244303.10
- Conserved Domains (3) summary
-
- cd00130
Location:172 → 269
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam11413
Location:411 → 440
- HIF-1; Hypoxia-inducible factor-1
- pfam14598
Location:172 → 279
- PAS_11; PAS domain
-
NM_152794.4 → NP_690007.1 hypoxia-inducible factor 3-alpha isoform a
See identical proteins and their annotated locations for NP_690007.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, compared to variant 3. The resulting isoform (a) has a distinct and shorter N-terminus, compared to isoform c.
- Source sequence(s)
-
AB054067, AC007193, AK314680, BM971722
- Consensus CDS
-
CCDS12682.1
- UniProtKB/TrEMBL
-
B2RBI6
- Related
- ENSP00000300862.3, ENST00000300862.7
- Conserved Domains (4) summary
-
- cd00083
Location:11 → 66
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:239 → 336
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam11413
Location:478 → 507
- HIF-1; Hypoxia-inducible factor-1
- pfam14598
Location:239 → 346
- PAS_11; PAS domain
-
NM_152795.4 → NP_690008.2 hypoxia-inducible factor 3-alpha isoform c
See identical proteins and their annotated locations for NP_690008.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) encodes the longest isoform (c).
- Source sequence(s)
-
AC007193, BC080551, BM971722, DR001068
- Consensus CDS
-
CCDS12681.2
- UniProtKB/Swiss-Prot
- B0M185, B4DNA2, I6L988, Q58A43, Q66K72, Q8WXA1, Q96K34, Q9H7Z9, Q9HAI2, Q9Y2N7
- UniProtKB/TrEMBL
-
B2RBI6
- Related
- ENSP00000366898.3, ENST00000377670.9
- Conserved Domains (4) summary
-
- cd00083
Location:13 → 68
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:241 → 338
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam11413
Location:480 → 509
- HIF-1; Hypoxia-inducible factor-1
- pfam14598
Location:241 → 348
- PAS_11; PAS domain
-
NM_152796.2 → NP_690009.1 hypoxia-inducible factor 3-alpha isoform d
See identical proteins and their annotated locations for NP_690009.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and differs in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (d) has distinct N- and C-termini, and is shorter than isoform c.
- Source sequence(s)
-
AC007193, AU143858, BE250295, CA437428, CF593418, DA559979, DC423791
- UniProtKB/TrEMBL
-
H0YDZ5
- Related
- ENSP00000434653.2, ENST00000472815.5
- Conserved Domains (3) summary
-
- cd00130
Location:172 → 269
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam13900
Location:429 → 450
- GVQW; Putative domain of unknown function
- pfam14598
Location:172 → 279
- PAS_11; PAS domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000019.10 Reference GRCh38.p14 Primary Assembly
- Range
-
46297042..46343433
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017027132.2 → XP_016882621.1 hypoxia-inducible factor 3-alpha isoform X1
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_005259152.5 → XP_005259209.1 hypoxia-inducible factor 3-alpha isoform X3
- UniProtKB/TrEMBL
-
B2RBI6
- Conserved Domains (4) summary
-
- cd00083
Location:57 → 112
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:285 → 382
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam11413
Location:524 → 553
- HIF-1; Hypoxia-inducible factor-1
- pfam14598
Location:285 → 392
- PAS_11; PAS domain
-
XM_047439216.1 → XP_047295172.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_017027134.2 → XP_016882623.1 hypoxia-inducible factor 3-alpha isoform X4
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_017027140.2 → XP_016882629.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_047439217.1 → XP_047295173.1 hypoxia-inducible factor 3-alpha isoform X13
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_017027133.2 → XP_016882622.1 hypoxia-inducible factor 3-alpha isoform X2
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_017027136.2 → XP_016882625.1 hypoxia-inducible factor 3-alpha isoform X6
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_047439214.1 → XP_047295170.1 hypoxia-inducible factor 3-alpha isoform X7
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_017027138.2 → XP_016882627.1 hypoxia-inducible factor 3-alpha isoform X9
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_047439218.1 → XP_047295174.1 hypoxia-inducible factor 3-alpha isoform X14
- UniProtKB/TrEMBL
- B4DSD9, M0R104
-
XM_005259156.5 → XP_005259213.1 hypoxia-inducible factor 3-alpha isoform X15
See identical proteins and their annotated locations for XP_005259213.1
- Conserved Domains (3) summary
-
- cd00130
Location:139 → 214
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- cd19729
Location:56 → 118
- bHLH-PAS_HIF3a_PASD7; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 3-alpha (HIF3a) and similar proteins
- pfam14598
Location:285 → 390
- PAS_11; PAS domain
-
XM_047439219.1 → XP_047295175.1 hypoxia-inducible factor 3-alpha isoform X16
-
XM_017027135.2 → XP_016882624.1 hypoxia-inducible factor 3-alpha isoform X5
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_017027141.2 → XP_016882630.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_005259153.4 → XP_005259210.3 hypoxia-inducible factor 3-alpha isoform X12
- UniProtKB/TrEMBL
-
B4DSD9
- Related
- ENSP00000471560.1, ENST00000600383.1
-
XM_017027137.2 → XP_016882626.1 hypoxia-inducible factor 3-alpha isoform X8
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_047439215.1 → XP_047295171.1 hypoxia-inducible factor 3-alpha isoform X10
- UniProtKB/TrEMBL
-
B2RBI6
Alternate T2T-CHM13v2.0
Genomic
-
NC_060943.1 Alternate T2T-CHM13v2.0
- Range
-
49124507..49170893
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054321743.1 → XP_054177718.1 hypoxia-inducible factor 3-alpha isoform X1
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321745.1 → XP_054177720.1 hypoxia-inducible factor 3-alpha isoform X3
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321753.1 → XP_054177728.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_054321746.1 → XP_054177721.1 hypoxia-inducible factor 3-alpha isoform X4
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321752.1 → XP_054177727.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_054321756.1 → XP_054177731.1 hypoxia-inducible factor 3-alpha isoform X13
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_054321744.1 → XP_054177719.1 hypoxia-inducible factor 3-alpha isoform X2
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321748.1 → XP_054177723.1 hypoxia-inducible factor 3-alpha isoform X6
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321749.1 → XP_054177724.1 hypoxia-inducible factor 3-alpha isoform X7
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321750.1 → XP_054177725.1 hypoxia-inducible factor 3-alpha isoform X9
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321757.1 → XP_054177732.1 hypoxia-inducible factor 3-alpha isoform X14
- UniProtKB/TrEMBL
- B4DSD9, M0R104
-
XM_054321758.1 → XP_054177733.1 hypoxia-inducible factor 3-alpha isoform X15
-
XM_054321759.1 → XP_054177734.1 hypoxia-inducible factor 3-alpha isoform X16
-
XM_054321747.1 → XP_054177722.1 hypoxia-inducible factor 3-alpha isoform X5
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321754.1 → XP_054177729.1 hypoxia-inducible factor 3-alpha isoform X11
- UniProtKB/TrEMBL
-
B4DSD9
-
XM_054321751.1 → XP_054177726.1 hypoxia-inducible factor 3-alpha isoform X10
- UniProtKB/TrEMBL
-
B2RBI6
-
XM_054321755.1 → XP_054177730.1 hypoxia-inducible factor 3-alpha isoform X17
- UniProtKB/TrEMBL
-
B4DSD9