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    IGFL1 IGF like family member 1 [ Homo sapiens (human) ]

    Gene ID: 374918, updated on 9-Dec-2024

    Summary

    Official Symbol
    IGFL1provided by HGNC
    Official Full Name
    IGF like family member 1provided by HGNC
    Primary source
    HGNC:HGNC:24093
    See related
    Ensembl:ENSG00000188293 MIM:610544; AllianceGenome:HGNC:24093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ644; APRG644
    Summary
    The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]
    Expression
    Restricted expression toward esophagus (RPKM 30.9) See more
    Orthologs
    NEW
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    Genomic context

    See IGFL1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46229742..46231243)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49057165..49058666)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46732999..46734500)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 2 Neighboring gene Sharpr-MPRA regulatory region 8129 Neighboring gene uncharacterized LOC93429 Neighboring gene MPRA-validated peak3520 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:46732347-46733546 Neighboring gene ribosomal protein L12 pseudogene 41 Neighboring gene uncharacterized LOC124904728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46763899-46764398 Neighboring gene IGF like family member 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    insulin growth factor-like family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198541.2NP_940943.1  insulin growth factor-like family member 1 precursor

      See identical proteins and their annotated locations for NP_940943.1

      Status: REVIEWED

      Source sequence(s)
      AC006262, AY359013
      Consensus CDS
      CCDS46123.1
      UniProtKB/Swiss-Prot
      Q6UW32
      Related
      ENSP00000415823.1, ENST00000437936.2
      Conserved Domains (1) summary
      pfam14653
      Location:3486
      IGFL; Insulin growth factor-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46229742..46231243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49057165..49058666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)