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    TP53RK TP53 regulating kinase [ Homo sapiens (human) ]

    Gene ID: 112858, updated on 9-Dec-2024

    Summary

    Official Symbol
    TP53RKprovided by HGNC
    Official Full Name
    TP53 regulating kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:16197
    See related
    Ensembl:ENSG00000172315 MIM:608679; AllianceGenome:HGNC:16197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRPK; BUD32; TPRKB; GAMOS4; Nori-2; Nori-2p; dJ101A2; C20orf64
    Summary
    Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 5.4), thyroid (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TP53RK in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46684365..46689444, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48420644..48425723, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45313004..45318083, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 334 Neighboring gene zinc finger protein 840, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45142238-45142472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45173599-45174450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17976 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45197011-45197512 Neighboring gene solute carrier family 13 member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45211603-45212425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45212426-45213247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:45250755-45251328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45259736-45260484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45260485-45261231 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45302100-45302256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45303169-45303683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45311939-45312450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17979 Neighboring gene TP53RK divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45331499-45332271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354240-45354740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354741-45355241 Neighboring gene solute carrier family 2 member 10 Neighboring gene uncharacterized LOC124904918

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EKC/KEOPS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    EKC/KEOPS complex subunit TP53RK
    Names
    atypical serine/threonine protein kinase TP53RK
    p53-related protein kinase
    NP_291028.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033550.4NP_291028.3  EKC/KEOPS complex subunit TP53RK

      See identical proteins and their annotated locations for NP_291028.3

      Status: VALIDATED

      Source sequence(s)
      AB017505, BC035461
      Consensus CDS
      CCDS13401.1
      UniProtKB/Swiss-Prot
      B3KU44, Q3T977, Q5JZ01, Q6NZ60, Q96FM7, Q96S44, Q9NQE6
      UniProtKB/TrEMBL
      B2RCM6
      Related
      ENSP00000361186.3, ENST00000372114.4
      Conserved Domains (1) summary
      COG3642
      Location:36253
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46684365..46689444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      48420644..48425723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)