U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GNGT1 G protein subunit gamma transducin 1 [ Homo sapiens (human) ]

    Gene ID: 2792, updated on 9-Dec-2024

    Summary

    Official Symbol
    GNGT1provided by HGNC
    Official Full Name
    G protein subunit gamma transducin 1provided by HGNC
    Primary source
    HGNC:HGNC:4411
    See related
    Ensembl:ENSG00000127928 MIM:189970; AllianceGenome:HGNC:4411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNG1; HG3G1
    Summary
    This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
    Expression
    Restricted expression toward placenta (RPKM 1.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GNGT1 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (93906567..93911265)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (95143218..95147911)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93535879..93540577)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tissue factor pathway inhibitor 2 Neighboring gene TFPI2 divergent transcript Neighboring gene uncharacterized LOC105375402 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:93543651-93544850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:93550649-93551284 Neighboring gene G protein subunit gamma 11 Neighboring gene BET1 antisense RNA 1 Neighboring gene Bet1 golgi vesicular membrane trafficking protein Neighboring gene ReSE screen-validated silencer GRCh37_chr7:93618399-93618603

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eye photoreceptor cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phototransduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
     
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(T) subunit gamma-T1
    Names
    guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
    heterotrimeric guanine nucleotide-binding protein 3G1
    transducin gamma chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051196.1 RefSeqGene

      Range
      5060..9758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329426.2NP_001316355.1  guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the same protein as variant 1.
      Source sequence(s)
      BG435040, BQ637754, EL950965
      Consensus CDS
      CCDS5633.1
      UniProtKB/Swiss-Prot
      A4D1H2, O43835, P63211, Q08447, Q16026, Q6LCP6
      Conserved Domains (1) summary
      smart00224
      Location:1274
      GGL; G protein gamma subunit-like motifs
    2. NM_021955.5NP_068774.1  guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor

      See identical proteins and their annotated locations for NP_068774.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC029367, BQ637754
      Consensus CDS
      CCDS5633.1
      UniProtKB/Swiss-Prot
      A4D1H2, O43835, P63211, Q08447, Q16026, Q6LCP6
      Related
      ENSP00000248572.5, ENST00000248572.10
      Conserved Domains (1) summary
      smart00224
      Location:1274
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      93906567..93911265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      95143218..95147911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)