U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SENP8 SUMO peptidase family member, NEDD8 specific [ Homo sapiens (human) ]

    Gene ID: 123228, updated on 3-Dec-2024

    Summary

    Official Symbol
    SENP8provided by HGNC
    Official Full Name
    SUMO peptidase family member, NEDD8 specificprovided by HGNC
    Primary source
    HGNC:HGNC:22992
    See related
    Ensembl:ENSG00000166192 MIM:608659; AllianceGenome:HGNC:22992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEN1; NEDP1; PRSC2
    Summary
    This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
    Expression
    Broad expression in testis (RPKM 2.2), thyroid (RPKM 1.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SENP8 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72114258..72143692)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (69930994..69960429)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72406599..72436033)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene eukaryotic translation initiation factor 5A2 pseudogene 1 Neighboring gene RNA, U2 small nuclear 65, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72394409-72394919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9712 Neighboring gene ribosomal protein L21 pseudogene 115 Neighboring gene uncharacterized LOC124903522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9713 Neighboring gene Sharpr-MPRA regulatory region 4122 Neighboring gene GRAM domain containing 2A Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:72485963-72486586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6617 Neighboring gene Sharpr-MPRA regulatory region 1213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6619 Neighboring gene pyruvate kinase M1/2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deNEDDylase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sentrin-specific protease 8
    Names
    NEDD8 specific-protease cysteine 2
    NEDD8-specific protease 1
    SUMO sentrin specific protease family member 8
    SUMO/sentrin peptidase family member, NEDD8 specific
    SUMO/sentrin specific peptidase family member 8
    deneddylase 1
    protease, cysteine 2
    NP_001159812.1
    NP_001165580.1
    NP_001165581.1
    NP_001165582.1
    NP_660205.3
    XP_005254214.1
    XP_011519519.1
    XP_054233238.1
    XP_054233239.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166340.2NP_001159812.1  sentrin-specific protease 8

      See identical proteins and their annotated locations for NP_001159812.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC020779, AK097557
      Consensus CDS
      CCDS10240.1
      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Related
      ENSP00000446057.2, ENST00000542035.2
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_001172109.1NP_001165580.1  sentrin-specific protease 8

      See identical proteins and their annotated locations for NP_001165580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein. An in-frame AUG is located 44 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC020779, AY008293, DB048641
      Consensus CDS
      CCDS10240.1
      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    3. NM_001172110.1NP_001165581.1  sentrin-specific protease 8

      See identical proteins and their annotated locations for NP_001165581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein. An in-frame AUG is located 44 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC020779, AY008293, BP370384
      Consensus CDS
      CCDS10240.1
      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    4. NM_001172111.2NP_001165582.1  sentrin-specific protease 8

      See identical proteins and their annotated locations for NP_001165582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein. An in-frame AUG is located 44 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC020779, AY008293, CN367895
      Consensus CDS
      CCDS10240.1
      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    5. NM_145204.4NP_660205.3  sentrin-specific protease 8

      See identical proteins and their annotated locations for NP_660205.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC020779, AK292298, AY008293
      Consensus CDS
      CCDS10240.1
      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Related
      ENSP00000340505.4, ENST00000340912.6
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72114258..72143692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254157.4XP_005254214.1  sentrin-specific protease 8 isoform X1

      See identical proteins and their annotated locations for XP_005254214.1

      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. XM_011521217.3XP_011519519.1  sentrin-specific protease 8 isoform X1

      See identical proteins and their annotated locations for XP_011519519.1

      UniProtKB/Swiss-Prot
      Q96LD8, Q96QA4
      UniProtKB/TrEMBL
      A8K8D3
      Conserved Domains (1) summary
      cl23802
      Location:26174
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      69930994..69960429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377263.1XP_054233238.1  sentrin-specific protease 8 isoform X1

      UniProtKB/TrEMBL
      A8K8D3
    2. XM_054377264.1XP_054233239.1  sentrin-specific protease 8 isoform X1

      UniProtKB/TrEMBL
      A8K8D3