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    CELF6 CUGBP Elav-like family member 6 [ Homo sapiens (human) ]

    Gene ID: 60677, updated on 9-Dec-2024

    Summary

    Official Symbol
    CELF6provided by HGNC
    Official Full Name
    CUGBP Elav-like family member 6provided by HGNC
    Primary source
    HGNC:HGNC:14059
    See related
    Ensembl:ENSG00000140488 MIM:612681; AllianceGenome:HGNC:14059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRUNOL6
    Summary
    Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in brain (RPKM 5.2), ovary (RPKM 3.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CELF6 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72284727..72320157, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70101200..70136631, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72577068..72612498, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9718 Neighboring gene uncharacterized LOC105370887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72634699-72635198 Neighboring gene hexosaminidase subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72667591-72668146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72668147-72668703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9721 Neighboring gene HEXA antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: HEXA

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    CUGBP Elav-like family member 6
    Names
    Bruno -like 6, RNA binding protein
    CUG-BP- and ETR-3-like factor 6
    RNA-binding protein BRUNOL-6
    bruno-like 6, RNA binding protein
    bruno-like protein 6
    NP_001166155.1
    NP_001166156.1
    NP_443072.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172684.2NP_001166155.1  CUGBP Elav-like family member 6 isoform 2

      See identical proteins and their annotated locations for NP_001166155.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC009690, AF401233, AK296004, DC368992
      Consensus CDS
      CCDS53956.1
      UniProtKB/Swiss-Prot
      Q96J87
      Related
      ENSP00000457863.1, ENST00000567083.2
      Conserved Domains (4) summary
      cd12632
      Location:41127
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:133213
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:365443
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:48454
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. NM_001172685.2NP_001166156.1  CUGBP Elav-like family member 6 isoform 3

      See identical proteins and their annotated locations for NP_001166156.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC009690, AK294382, KF456093
      Consensus CDS
      CCDS53955.1
      UniProtKB/TrEMBL
      B3KWE6
      Related
      ENSP00000439956.2, ENST00000543764.6
      Conserved Domains (3) summary
      cd12635
      Location:1898
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:255333
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:2340
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. NM_052840.5NP_443072.3  CUGBP Elav-like family member 6 isoform 1

      See identical proteins and their annotated locations for NP_443072.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF401233, AK131098, BM681937, BU732838, CA393931
      Consensus CDS
      CCDS10242.1
      UniProtKB/Swiss-Prot
      B4DG28, B4DJB6, Q6PII4, Q6ZNJ7, Q8N607, Q96J87
      Related
      ENSP00000287202.5, ENST00000287202.10
      Conserved Domains (4) summary
      cd12632
      Location:41127
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:133213
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:392470
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:48477
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72284727..72320157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70101200..70136631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)