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    GOLGA6B golgin A6 family member B [ Homo sapiens (human) ]

    Gene ID: 55889, updated on 9-Dec-2024

    Summary

    Official Symbol
    GOLGA6Bprovided by HGNC
    Official Full Name
    golgin A6 family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:32205
    See related
    Ensembl:ENSG00000215186 AllianceGenome:HGNC:32205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOLGA; GOLGA6D
    Summary
    This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, which are greater than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosomal rearrangements that underlie genomic disease. This gene is a member of the golgin gene family, whose protein products localize to the Golgi apparatus. The majority of the related gene copies are thought to be transcribed pseudogenes. It is not known whether this gene is a pseudogene or if it encodes a golgin protein. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 10.1) See more
    Orthologs
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    Genomic context

    See GOLGA6B in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72654697..72669599)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70472014..70486922)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72947038..72961940)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72902139-72902639 Neighboring gene golgin A6 family member A pseudogene Neighboring gene long intergenic non-protein coding RNA 2259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72920983-72921575 Neighboring gene uncharacterized LOC112268145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72939289-72940171 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:72942597-72943114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72954615-72955116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72955117-72955616 Neighboring gene RNA, 7SL, cytoplasmic 853, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72963099-72964076 Neighboring gene HIG1 hypoxia inducible domain family member 2B Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene MPRA-validated peak2381 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    golgin subfamily A member 6B
    Names
    Golgin subfamily A member 6B
    Putative golgin subfamily A member 6D
    golgi autoantigen, golgin subfamily a, 6B
    golgin-like protein
    putative golgin subfamily A member 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018652.5NP_061122.4  golgin subfamily A member 6B

      See identical proteins and their annotated locations for NP_061122.4

      Status: REVIEWED

      Source sequence(s)
      AC009712, AC100827
      Consensus CDS
      CCDS10245.2
      UniProtKB/Swiss-Prot
      A6NDN3, A8MYY7
      UniProtKB/TrEMBL
      A2VDJ1
      Related
      ENSP00000408132.3, ENST00000421285.4
      Conserved Domains (2) summary
      pfam01496
      Location:264346
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam15070
      Location:217686
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72654697..72669599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70472014..70486922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)