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    NCOA5 nuclear receptor coactivator 5 [ Homo sapiens (human) ]

    Gene ID: 57727, updated on 27-Nov-2024

    Summary

    Official Symbol
    NCOA5provided by HGNC
    Official Full Name
    nuclear receptor coactivator 5provided by HGNC
    Primary source
    HGNC:HGNC:15909
    See related
    Ensembl:ENSG00000124160 MIM:616825; AllianceGenome:HGNC:15909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIA; bA465L10.6
    Summary
    This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in testis (RPKM 19.7), ovary (RPKM 15.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NCOA5 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46060991..46089962, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47797006..47826000, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44689630..44718601, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44640983-44641493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12969 Neighboring gene SLC12A5 and MMP9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12971 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12 member 5 Neighboring gene Sharpr-MPRA regulatory region 13245 Neighboring gene Sharpr-MPRA regulatory region 3425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17957 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:44717073-44717887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44717888-44718701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17960 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:44731180-44731415 Neighboring gene ribosomal protein L13 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17962 Neighboring gene CRISPRi-FlowFISH-validated CD40 regulatory element GRCh37_chr20:44746135-44748232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17965 Neighboring gene CD40 molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    nuclear receptor coactivator 5
    Names
    NCoA-5
    coactivator independent of AF-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348148.2NP_001335077.1  nuclear receptor coactivator 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (1) summary
      COG0124
      Location:81151
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    2. NM_001348149.2NP_001335078.1  nuclear receptor coactivator 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (2) summary
      COG0124
      Location:186256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      PRK12678
      Location:32118
      PRK12678; transcription termination factor Rho; Provisional
    3. NM_001348150.2NP_001335079.1  nuclear receptor coactivator 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458, BC056872, CN369226
      Conserved Domains (1) summary
      COG0124
      Location:123193
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    4. NM_001348151.2NP_001335080.1  nuclear receptor coactivator 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (1) summary
      COG0124
      Location:81151
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    5. NM_020967.3NP_066018.1  nuclear receptor coactivator 5 isoform 1

      See identical proteins and their annotated locations for NP_066018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF230533, AL035662, AL162458, CN369226
      Consensus CDS
      CCDS13392.1
      UniProtKB/Swiss-Prot
      B2RTV9, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9, Q9HCD5
      Related
      ENSP00000290231.6, ENST00000290231.11
      Conserved Domains (2) summary
      COG0124
      Location:186256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      PRK12678
      Location:32135
      PRK12678; transcription termination factor Rho; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46060991..46089962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47797006..47826000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)