NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_020820.4 → NP_065871.3 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Status: REVIEWED
- Source sequence(s)
-
AL035106, AL133342, AL445192
- Consensus CDS
-
CCDS13410.1
- UniProtKB/Swiss-Prot
- E1P5X9, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q8TCU6, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4
- UniProtKB/TrEMBL
-
A0A2X0SFH1
- Related
- ENSP00000361009.3, ENST00000371941.4
- Conserved Domains (6) summary
-
- cd00136
Location:721 → 773
- PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
- cd00160
Location:50 → 238
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd00992
Location:627 → 703
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd04440
Location:506 → 598
- DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
- cd01224
Location:244 → 396
- PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
- cl02442
Location:414 → 494
- DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000020.11 Reference GRCh38.p14 Primary Assembly
- Range
-
48624252..48888185 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047440333.1 → XP_047296289.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFH1
-
XM_047440332.1 → XP_047296288.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFH1
-
XM_047440331.1 → XP_047296287.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFH1
-
XM_011528934.2 → XP_011527236.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2
- Conserved Domains (4) summary
-
- cd00136
Location:321 → 373
- PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
- cd00992
Location:227 → 303
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd04440
Location:106 → 198
- DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
- cl02442
Location:14 → 94
- DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
-
XM_047440334.1 → XP_047296290.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060944.1 Alternate T2T-CHM13v2.0
- Range
-
50394065..50597825 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054323770.1 → XP_054179745.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1
- UniProtKB/TrEMBL
-
A0A2X0SFH1
-
XM_054323771.1 → XP_054179746.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2
-
XM_054323772.1 → XP_054179747.1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X3