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    TRH thyrotropin releasing hormone [ Homo sapiens (human) ]

    Gene ID: 7200, updated on 27-Nov-2024

    Summary

    Official Symbol
    TRHprovided by HGNC
    Official Full Name
    thyrotropin releasing hormoneprovided by HGNC
    Primary source
    HGNC:HGNC:12298
    See related
    Ensembl:ENSG00000170893 MIM:613879; AllianceGenome:HGNC:12298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRF; Pro-TRH
    Summary
    This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
    Expression
    Biased expression in endometrium (RPKM 11.5), bone marrow (RPKM 1.1) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See TRH in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129974720..129977935)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132718521..132721736)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129693563..129696778)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene uncharacterized LOC124906340 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:129550881-129551035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129611136-129611928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129611929-129612720 Neighboring gene MPRA-validated peak4828 silencer Neighboring gene MPRA-validated peak4829 silencer Neighboring gene TMCC1 divergent transcript Neighboring gene collagen alpha-1(III) chain-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129720491-129721337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14730 Neighboring gene ribosomal protein S17 pseudogene 9 Neighboring gene VPS51 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125964, MGC125965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thyrotropin-releasing hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in eating behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glutamate secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gamma-aminobutyric acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    thyrotropin releasing hormone
    Names
    TSH-releasing factor
    pro-thyrotropin-releasing hormone
    prothyroliberin
    protirelin
    thyrotropin-releasing factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027816.1 RefSeqGene

      Range
      5450..8665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007117.5NP_009048.1  thyrotropin releasing hormone preproprotein

      See identical proteins and their annotated locations for NP_009048.1

      Status: REVIEWED

      Source sequence(s)
      AC083906, AK313473
      Consensus CDS
      CCDS3066.1
      UniProtKB/Swiss-Prot
      B2R8R1, P20396, Q2TB83
      UniProtKB/TrEMBL
      D6RFM1
      Related
      ENSP00000303452.3, ENST00000302649.4
      Conserved Domains (1) summary
      pfam05438
      Location:18203
      TRH; Thyrotropin-releasing hormone (TRH)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      129974720..129977935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      132718521..132721736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)