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    WNK2 WNK lysine deficient protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 65268, updated on 10-Dec-2024

    Summary

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    Official Symbol
    WNK2provided by HGNC
    Official Full Name
    WNK lysine deficient protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:14542
    See related
    Ensembl:ENSG00000165238 MIM:606249; AllianceGenome:HGNC:14542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13
    Summary
    The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WNK2 in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93184139..93320569)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105350754..105487952)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95946421..96082851)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95897247-95897843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95905234-95906106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95906107-95906979 Neighboring gene Sharpr-MPRA regulatory region 13679 Neighboring gene ninjurin 1 Neighboring gene uncharacterized LOC124902213 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95913665-95914165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95935533-95936106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95948459-95949424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95951526-95952459 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:95955296-95955514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95964080-95965013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96000334-96000834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96007029-96007528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96025151-96025819 Neighboring gene uncharacterized LOC124902214 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96050932-96051728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96061034-96061534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96063483-96064395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96068651-96069555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96088631-96089132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96089133-96089632 Neighboring gene family with sequence similarity 120A2, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:96109682-96110628 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:96112805-96113334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:96114925-96115454 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:96115455-96115984 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109877 Neighboring gene RNA, U6 small nuclear 829, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth. Hong C, et al. Proc Natl Acad Sci U S A, 2007 Jun 26. PMID 17578925, Free PMC Article
    2. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Jun P, et al. Neuro Oncol, 2009 Aug. PMID 19001526, Free PMC Article
    3. Germline mutations in WNK2 could be associated with serrated polyposis syndrome. Soares de Lima Y, et al. J Med Genet, 2023 Jun. PMID 36270769, Free PMC Article
    4. Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence. Zhou SL, et al. J Hepatol, 2019 Dec. PMID 31349001
    5. WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line. Alves ALV, et al. Cells, 2020 Feb 20. PMID 32093151, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAX6-WNK2 Axis Governs Corneal Epithelial Homeostasis.
      Title: PAX6-WNK2 Axis Governs Corneal Epithelial Homeostasis.
    2. Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers.
      Title: Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers.
    3. Germline mutations in WNK2 could be associated with serrated polyposis syndrome.
      Title: Germline mutations in WNK2 could be associated with serrated polyposis syndrome.
    4. WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
      Title: WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
    5. Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression.
      Title: Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression.
    6. LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation.
      Title: LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation.
    7. Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence.
      Title: Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence.
    8. Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation.
      Title: Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation.
    9. WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line.
      Title: WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line.
    10. Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4alpha and WNK2 regulation.
      Title: Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4α and WNK2 regulation.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1760

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK2
    Names
    antigen NY-CO-43
    mitogen-activated protein kinase kinase kinase
    protein kinase lysine-deficient 2
    protein kinase with no lysine 2
    serologically defined colon cancer antigen 43
    NP_001269323.1
    NP_006639.3
    XP_005252194.1
    XP_005252197.1
    XP_005252201.1
    XP_016870534.1
    XP_016870536.1
    XP_016870537.1
    XP_016870538.1
    XP_016870539.1
    XP_016870540.1
    XP_016870541.1
    XP_016870542.1
    XP_016870543.1
    XP_016870544.1
    XP_047279697.1
    XP_047279698.1
    XP_047279699.1
    XP_047279700.1
    XP_047279701.1
    XP_047279702.1
    XP_047279703.1
    XP_047279704.1
    XP_047279705.1
    XP_047279706.1
    XP_047279707.1
    XP_047279708.1
    XP_047279709.1
    XP_047279710.1
    XP_047279712.1
    XP_047279713.1
    XP_047279714.1
    XP_047279715.1
    XP_047279716.1
    XP_047279717.1
    XP_047279718.1
    XP_047279719.1
    XP_047279720.1
    XP_047279721.1
    XP_047279723.1
    XP_047279724.1
    XP_047279725.1
    XP_047279726.1
    XP_047279727.1
    XP_047279728.1
    XP_047279729.1
    XP_047279730.1
    XP_047279731.1
    XP_047279732.1
    XP_047279734.1
    XP_047279735.1
    XP_054219548.1
    XP_054219549.1
    XP_054219550.1
    XP_054219551.1
    XP_054219552.1
    XP_054219553.1
    XP_054219554.1
    XP_054219555.1
    XP_054219556.1
    XP_054219557.1
    XP_054219558.1
    XP_054219559.1
    XP_054219560.1
    XP_054219561.1
    XP_054219562.1
    XP_054219563.1
    XP_054219564.1
    XP_054219565.1
    XP_054219566.1
    XP_054219567.1
    XP_054219568.1
    XP_054219569.1
    XP_054219570.1
    XP_054219571.1
    XP_054219572.1
    XP_054219573.1
    XP_054219574.1
    XP_054219575.1
    XP_054219576.1
    XP_054219577.1
    XP_054219578.1
    XP_054219579.1
    XP_054219580.1
    XP_054219581.1
    XP_054219582.1
    XP_054219583.1
    XP_054219584.1
    XP_054219585.1
    XP_054219586.1
    XP_054219587.1
    XP_054219588.1
    XP_054219589.1
    XP_054219590.1
    XP_054219591.1
    XP_054219592.1
    XP_054219593.1
    XP_054219594.1
    XP_054219595.1
    XP_054219596.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282394.3 → NP_001269323.1  serine/threonine-protein kinase WNK2 isoform 1

      See identical proteins and their annotated locations for NP_001269323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL354991, AL390760, AL583839
      Consensus CDS
      CCDS75858.1
      UniProtKB/Swiss-Prot
      Q5VWF1, Q5VWF2, Q8IY36, Q9C0A3, Q9H3P4, Q9Y3S1
      UniProtKB/TrEMBL
      H0Y7T5
      Related
      ENSP00000297954.4, ENST00000297954.9
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. NM_006648.4 → NP_006639.3  serine/threonine-protein kinase WNK2 isoform 2

      See identical proteins and their annotated locations for NP_006639.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL354991, AL390760, AL583839
      UniProtKB/TrEMBL
      E9PCD1, F8W9F9, H0Y7T5
      Related
      ENSP00000411181.4, ENST00000427277.7
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      93184139..93320569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423745.1 → XP_047279701.1  serine/threonine-protein kinase WNK2 isoform X16

      UniProtKB/TrEMBL
      H0Y7T5

    2. XM_047423751.1 → XP_047279707.1  serine/threonine-protein kinase WNK2 isoform X22

      UniProtKB/TrEMBL
      H0Y7T5

    3. XM_047423761.1 → XP_047279717.1  serine/threonine-protein kinase WNK2 isoform X33

      UniProtKB/TrEMBL
      H0Y7T5

    4. XM_047423767.1 → XP_047279723.1  serine/threonine-protein kinase WNK2 isoform X38

      UniProtKB/TrEMBL
      H0Y7T5

    5. XM_047423754.1 → XP_047279710.1  serine/threonine-protein kinase WNK2 isoform X27

      UniProtKB/TrEMBL
      H0Y7T5

    6. XM_047423741.1 → XP_047279697.1  serine/threonine-protein kinase WNK2 isoform X8

      UniProtKB/TrEMBL
      H0Y7T5

    7. XM_047423747.1 → XP_047279703.1  serine/threonine-protein kinase WNK2 isoform X18

      UniProtKB/TrEMBL
      H0Y7T5

    8. XM_047423752.1 → XP_047279708.1  serine/threonine-protein kinase WNK2 isoform X23

      UniProtKB/TrEMBL
      H0Y7T5

    9. XM_047423762.1 → XP_047279718.1  serine/threonine-protein kinase WNK2 isoform X34

      UniProtKB/TrEMBL
      H0Y7T5

    10. XM_047423768.1 → XP_047279724.1  serine/threonine-protein kinase WNK2 isoform X39

      UniProtKB/TrEMBL
      H0Y7T5

    11. XM_047423753.1 → XP_047279709.1  serine/threonine-protein kinase WNK2 isoform X24

      UniProtKB/TrEMBL
      H0Y7T5

    12. XM_047423756.1 → XP_047279712.1  serine/threonine-protein kinase WNK2 isoform X28

      UniProtKB/TrEMBL
      H0Y7T5

    13. XM_047423770.1 → XP_047279726.1  serine/threonine-protein kinase WNK2 isoform X41

      UniProtKB/TrEMBL
      H0Y7T5

    14. XM_047423771.1 → XP_047279727.1  serine/threonine-protein kinase WNK2 isoform X42

      UniProtKB/TrEMBL
      H0Y7T5

    15. XM_005252137.4 → XP_005252194.1  serine/threonine-protein kinase WNK2 isoform X1

      UniProtKB/TrEMBL
      H0Y7T5
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    16. XM_005252140.3 → XP_005252197.1  serine/threonine-protein kinase WNK2 isoform X7

      UniProtKB/TrEMBL
      H0Y7T5
      Related
      ENSP00000415038.2, ENST00000432730.6
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    17. XM_017015049.2 → XP_016870538.1  serine/threonine-protein kinase WNK2 isoform X5

      UniProtKB/TrEMBL
      H0Y7T5

    18. XM_047423742.1 → XP_047279698.1  serine/threonine-protein kinase WNK2 isoform X10

      UniProtKB/TrEMBL
      H0Y7T5

    19. XM_047423749.1 → XP_047279705.1  serine/threonine-protein kinase WNK2 isoform X20

      UniProtKB/TrEMBL
      H0Y7T5

    20. XM_017015054.2 → XP_016870543.1  serine/threonine-protein kinase WNK2 isoform X25

      UniProtKB/TrEMBL
      H0Y7T5

    21. XM_047423757.1 → XP_047279713.1  serine/threonine-protein kinase WNK2 isoform X29

      UniProtKB/TrEMBL
      H0Y7T5

    22. XM_047423764.1 → XP_047279720.1  serine/threonine-protein kinase WNK2 isoform X36

      UniProtKB/TrEMBL
      H0Y7T5

    23. XM_017015047.2 → XP_016870536.1  serine/threonine-protein kinase WNK2 isoform X3

      UniProtKB/TrEMBL
      H0Y7T5

    24. XM_017015052.2 → XP_016870541.1  serine/threonine-protein kinase WNK2 isoform X12

      UniProtKB/TrEMBL
      H0Y7T5

    25. XM_047423744.1 → XP_047279700.1  serine/threonine-protein kinase WNK2 isoform X14

      UniProtKB/TrEMBL
      H0Y7T5

    26. XM_017015045.2 → XP_016870534.1  serine/threonine-protein kinase WNK2 isoform X2

      UniProtKB/TrEMBL
      H0Y7T5

    27. XM_017015050.2 → XP_016870539.1  serine/threonine-protein kinase WNK2 isoform X6

      UniProtKB/TrEMBL
      H0Y7T5

    28. XM_047423743.1 → XP_047279699.1  serine/threonine-protein kinase WNK2 isoform X11

      UniProtKB/TrEMBL
      H0Y7T5

    29. XM_047423750.1 → XP_047279706.1  serine/threonine-protein kinase WNK2 isoform X21

      UniProtKB/TrEMBL
      H0Y7T5

    30. XM_017015055.2 → XP_016870544.1  serine/threonine-protein kinase WNK2 isoform X26

      UniProtKB/TrEMBL
      H0Y7T5

    31. XM_047423758.1 → XP_047279714.1  serine/threonine-protein kinase WNK2 isoform X30

      UniProtKB/TrEMBL
      H0Y7T5

    32. XM_047423765.1 → XP_047279721.1  serine/threonine-protein kinase WNK2 isoform X37

      UniProtKB/TrEMBL
      H0Y7T5

    33. XM_017015048.2 → XP_016870537.1  serine/threonine-protein kinase WNK2 isoform X4

      UniProtKB/TrEMBL
      H0Y7T5

    34. XM_017015053.2 → XP_016870542.1  serine/threonine-protein kinase WNK2 isoform X13

      UniProtKB/TrEMBL
      H0Y7T5

    35. XM_017015051.2 → XP_016870540.1  serine/threonine-protein kinase WNK2 isoform X9

      UniProtKB/TrEMBL
      H0Y7T5

    36. XM_047423748.1 → XP_047279704.1  serine/threonine-protein kinase WNK2 isoform X19

      UniProtKB/TrEMBL
      H0Y7T5

    37. XM_005252144.3 → XP_005252201.1  serine/threonine-protein kinase WNK2 isoform X15

      UniProtKB/TrEMBL
      H0Y7T5
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    38. XM_047423759.1 → XP_047279715.1  serine/threonine-protein kinase WNK2 isoform X31

      UniProtKB/TrEMBL
      H0Y7T5

    39. XM_047423769.1 → XP_047279725.1  serine/threonine-protein kinase WNK2 isoform X40

      UniProtKB/TrEMBL
      H0Y7T5

    40. XM_047423763.1 → XP_047279719.1  serine/threonine-protein kinase WNK2 isoform X35

      UniProtKB/TrEMBL
      H0Y7T5

    41. XM_047423746.1 → XP_047279702.1  serine/threonine-protein kinase WNK2 isoform X17

      UniProtKB/TrEMBL
      H0Y7T5

    42. XM_047423760.1 → XP_047279716.1  serine/threonine-protein kinase WNK2 isoform X32

      UniProtKB/TrEMBL
      H0Y7T5

    43. XM_047423773.1 → XP_047279729.1  serine/threonine-protein kinase WNK2 isoform X44

      UniProtKB/TrEMBL
      H0Y7T5

    44. XM_047423778.1 → XP_047279734.1  serine/threonine-protein kinase WNK2 isoform X48

      UniProtKB/TrEMBL
      H0Y7R3

    45. XM_047423774.1 → XP_047279730.1  serine/threonine-protein kinase WNK2 isoform X45

      UniProtKB/TrEMBL
      H0Y7T5

    46. XM_047423775.1 → XP_047279731.1  serine/threonine-protein kinase WNK2 isoform X46

      UniProtKB/TrEMBL
      H0Y7R3
      Related
      ENSP00000414622.1, ENST00000411624.5

    47. XM_047423772.1 → XP_047279728.1  serine/threonine-protein kinase WNK2 isoform X43

      UniProtKB/TrEMBL
      H0Y7T5

    48. XM_047423776.1 → XP_047279732.1  serine/threonine-protein kinase WNK2 isoform X47

      UniProtKB/TrEMBL
      H0Y7T5

    49. XM_047423779.1 → XP_047279735.1  serine/threonine-protein kinase WNK2 isoform X49

      UniProtKB/TrEMBL
      H0Y7R3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      105350754..105487952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363588.1 → XP_054219563.1  serine/threonine-protein kinase WNK2 isoform X16

      UniProtKB/TrEMBL
      H0Y7T5

    2. XM_054363594.1 → XP_054219569.1  serine/threonine-protein kinase WNK2 isoform X22

      UniProtKB/TrEMBL
      H0Y7T5

    3. XM_054363605.1 → XP_054219580.1  serine/threonine-protein kinase WNK2 isoform X33

      UniProtKB/TrEMBL
      H0Y7T5

    4. XM_054363610.1 → XP_054219585.1  serine/threonine-protein kinase WNK2 isoform X38

      UniProtKB/TrEMBL
      H0Y7T5

    5. XM_054363599.1 → XP_054219574.1  serine/threonine-protein kinase WNK2 isoform X27

      UniProtKB/TrEMBL
      H0Y7T5

    6. XM_054363580.1 → XP_054219555.1  serine/threonine-protein kinase WNK2 isoform X8

      UniProtKB/TrEMBL
      H0Y7T5

    7. XM_054363590.1 → XP_054219565.1  serine/threonine-protein kinase WNK2 isoform X18

      UniProtKB/TrEMBL
      H0Y7T5

    8. XM_054363595.1 → XP_054219570.1  serine/threonine-protein kinase WNK2 isoform X23

      UniProtKB/TrEMBL
      H0Y7T5

    9. XM_054363606.1 → XP_054219581.1  serine/threonine-protein kinase WNK2 isoform X34

      UniProtKB/TrEMBL
      H0Y7T5

    10. XM_054363611.1 → XP_054219586.1  serine/threonine-protein kinase WNK2 isoform X39

      UniProtKB/TrEMBL
      H0Y7T5

    11. XM_054363596.1 → XP_054219571.1  serine/threonine-protein kinase WNK2 isoform X24

      UniProtKB/TrEMBL
      H0Y7T5

    12. XM_054363600.1 → XP_054219575.1  serine/threonine-protein kinase WNK2 isoform X28

      UniProtKB/TrEMBL
      H0Y7T5

    13. XM_054363613.1 → XP_054219588.1  serine/threonine-protein kinase WNK2 isoform X41

      UniProtKB/TrEMBL
      H0Y7T5

    14. XM_054363614.1 → XP_054219589.1  serine/threonine-protein kinase WNK2 isoform X42

      UniProtKB/TrEMBL
      H0Y7T5

    15. XM_054363573.1 → XP_054219548.1  serine/threonine-protein kinase WNK2 isoform X1

      UniProtKB/TrEMBL
      H0Y7T5

    16. XM_054363579.1 → XP_054219554.1  serine/threonine-protein kinase WNK2 isoform X7

      UniProtKB/TrEMBL
      H0Y7T5

    17. XM_054363577.1 → XP_054219552.1  serine/threonine-protein kinase WNK2 isoform X5

      UniProtKB/TrEMBL
      H0Y7T5

    18. XM_054363582.1 → XP_054219557.1  serine/threonine-protein kinase WNK2 isoform X10

      UniProtKB/TrEMBL
      H0Y7T5

    19. XM_054363592.1 → XP_054219567.1  serine/threonine-protein kinase WNK2 isoform X20

      UniProtKB/TrEMBL
      H0Y7T5

    20. XM_054363597.1 → XP_054219572.1  serine/threonine-protein kinase WNK2 isoform X25

      UniProtKB/TrEMBL
      H0Y7T5

    21. XM_054363601.1 → XP_054219576.1  serine/threonine-protein kinase WNK2 isoform X29

      UniProtKB/TrEMBL
      H0Y7T5

    22. XM_054363608.1 → XP_054219583.1  serine/threonine-protein kinase WNK2 isoform X36

      UniProtKB/TrEMBL
      H0Y7T5

    23. XM_054363575.1 → XP_054219550.1  serine/threonine-protein kinase WNK2 isoform X3

      UniProtKB/TrEMBL
      H0Y7T5

    24. XM_054363584.1 → XP_054219559.1  serine/threonine-protein kinase WNK2 isoform X12

      UniProtKB/TrEMBL
      H0Y7T5

    25. XM_054363586.1 → XP_054219561.1  serine/threonine-protein kinase WNK2 isoform X14

      UniProtKB/TrEMBL
      H0Y7T5

    26. XM_054363574.1 → XP_054219549.1  serine/threonine-protein kinase WNK2 isoform X2

      UniProtKB/TrEMBL
      H0Y7T5

    27. XM_054363578.1 → XP_054219553.1  serine/threonine-protein kinase WNK2 isoform X6

      UniProtKB/TrEMBL
      H0Y7T5

    28. XM_054363583.1 → XP_054219558.1  serine/threonine-protein kinase WNK2 isoform X11

      UniProtKB/TrEMBL
      H0Y7T5

    29. XM_054363593.1 → XP_054219568.1  serine/threonine-protein kinase WNK2 isoform X21

      UniProtKB/TrEMBL
      H0Y7T5

    30. XM_054363598.1 → XP_054219573.1  serine/threonine-protein kinase WNK2 isoform X26

      UniProtKB/TrEMBL
      H0Y7T5

    31. XM_054363602.1 → XP_054219577.1  serine/threonine-protein kinase WNK2 isoform X30

      UniProtKB/TrEMBL
      H0Y7T5

    32. XM_054363609.1 → XP_054219584.1  serine/threonine-protein kinase WNK2 isoform X37

      UniProtKB/TrEMBL
      H0Y7T5

    33. XM_054363576.1 → XP_054219551.1  serine/threonine-protein kinase WNK2 isoform X4

      UniProtKB/TrEMBL
      H0Y7T5

    34. XM_054363585.1 → XP_054219560.1  serine/threonine-protein kinase WNK2 isoform X13

      UniProtKB/TrEMBL
      H0Y7T5

    35. XM_054363581.1 → XP_054219556.1  serine/threonine-protein kinase WNK2 isoform X9

      UniProtKB/TrEMBL
      H0Y7T5

    36. XM_054363591.1 → XP_054219566.1  serine/threonine-protein kinase WNK2 isoform X19

      UniProtKB/TrEMBL
      H0Y7T5

    37. XM_054363587.1 → XP_054219562.1  serine/threonine-protein kinase WNK2 isoform X15

      UniProtKB/TrEMBL
      H0Y7T5

    38. XM_054363603.1 → XP_054219578.1  serine/threonine-protein kinase WNK2 isoform X31

      UniProtKB/TrEMBL
      H0Y7T5

    39. XM_054363612.1 → XP_054219587.1  serine/threonine-protein kinase WNK2 isoform X40

      UniProtKB/TrEMBL
      H0Y7T5

    40. XM_054363607.1 → XP_054219582.1  serine/threonine-protein kinase WNK2 isoform X35

      UniProtKB/TrEMBL
      H0Y7T5

    41. XM_054363589.1 → XP_054219564.1  serine/threonine-protein kinase WNK2 isoform X17

      UniProtKB/TrEMBL
      H0Y7T5

    42. XM_054363604.1 → XP_054219579.1  serine/threonine-protein kinase WNK2 isoform X32

      UniProtKB/TrEMBL
      H0Y7T5

    43. XM_054363616.1 → XP_054219591.1  serine/threonine-protein kinase WNK2 isoform X44

      UniProtKB/TrEMBL
      H0Y7T5

    44. XM_054363620.1 → XP_054219595.1  serine/threonine-protein kinase WNK2 isoform X48

      UniProtKB/TrEMBL
      H0Y7R3

    45. XM_054363617.1 → XP_054219592.1  serine/threonine-protein kinase WNK2 isoform X45

      UniProtKB/TrEMBL
      H0Y7T5

    46. XM_054363618.1 → XP_054219593.1  serine/threonine-protein kinase WNK2 isoform X46

      UniProtKB/TrEMBL
      H0Y7R3

    47. XM_054363615.1 → XP_054219590.1  serine/threonine-protein kinase WNK2 isoform X43

      UniProtKB/TrEMBL
      H0Y7T5

    48. XM_054363619.1 → XP_054219594.1  serine/threonine-protein kinase WNK2 isoform X47

      UniProtKB/TrEMBL
      H0Y7T5

    49. XM_054363621.1 → XP_054219596.1  serine/threonine-protein kinase WNK2 isoform X49

      UniProtKB/TrEMBL
      H0Y7R3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y3S1.4 GenPept UniProtKB/Swiss-Prot:Q9Y3S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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