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    NBR2 neighbor of BRCA1 lncRNA 2 [ Homo sapiens (human) ]

    Gene ID: 10230, updated on 17-Sep-2024

    Summary

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    Official Symbol
    NBR2provided by HGNC
    Official Full Name
    neighbor of BRCA1 lncRNA 2provided by HGNC
    Primary source
    HGNC:HGNC:20691
    See related
    Ensembl:ENSG00000198496 MIM:618708; AllianceGenome:HGNC:20691
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00192
    Summary
    This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.8), spleen (RPKM 3.3) and 25 other tissues See more
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    Genomic context

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    See NBR2 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43125557..43153671)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43984189..44012426)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41277574..41305688)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41195058-41195600 Neighboring gene Rho family GTPase 2 Neighboring gene BRCA1 DNA repair associated Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:41214996-41215531 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41224055-41224260 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:41243136-41244335 Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region Neighboring gene BRCA1 promoter region Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:41298599-41299208 Neighboring gene uncharacterized LOC101929767 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29 Neighboring gene BRCA1P1 intergenic recombination region Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41311429-41311959 Neighboring gene uncharacterized LOC124900391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12239 Neighboring gene BRCA1 pseudogene 1 Neighboring gene NBR1 autophagy cargo receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Xu CF, et al. Hum Mol Genet, 1997 Jul. PMID 9215675
    2. Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM. Lai F, et al. Bioengineered, 2021 Dec. PMID 34506209, Free PMC Article
    3. LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis. Zhu C, et al. Cell Cycle, 2021 Mar-Mar. PMID 33651649, Free PMC Article
    4. LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma. Sheng JQ, et al. Biomed Pharmacother, 2021 Jan. PMID 33378941
    5. Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway. Yu H, et al. Technol Cancer Res Treat, 2019 Jan-Dec. PMID 31888414, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA NBR2 suppresses the progression of colorectal cancer by downregulating miR-19a to regulate M2 macrophage polarization.
      Title: Long non-coding RNA NBR2 suppresses the progression of colorectal cancer by downregulating miR-19a to regulate M2 macrophage polarization.
    2. LncRNA NBR2 Regulates Cancer Cell Stemness and Predicts Survival in Non-small Cell Cancer Patients by Downregulating TGF-beta1.
      Title: LncRNA NBR2 Regulates Cancer Cell Stemness and Predicts Survival in Non-small Cell Cancer Patients by Downregulating TGF-β1.
    3. NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.
      Title: NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.
    4. LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis.
      Title: LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis.
    5. Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM.
      Title: Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM.
    6. NBR2 promotes the proliferation of glioma cells via inhibiting p15 expression.
      Title: NBR2 promotes the proliferation of glioma cells via inhibiting p15 expression.
    7. LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma.
      Title: LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma.
    8. LncRNA NBR2 inhibits EMT progression by regulating Notch1 pathway in NSCLC.
      Title: LncRNA NBR2 inhibits EMT progression by regulating Notch1 pathway in NSCLC.
    9. This study revealed a novel mechanism by which long noncoding RNA NBR2 mediates curcumin suppression of colorectal cancer proliferation by activating adenosine monophosphate-activated protein kinase and inactivating the mTOR signaling pathway.
      Title: Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway.
    10. data suggested that miR-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN/LPS-stimulated hepatocytes via regulating NBR2 and AMPK/PPARalpha signaling.
      Title: MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPARα in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • Neighbor of BRCA1 gene 2 protein
    • Next to BRCA1 gene 2 protein
    • neighbor of BRCA1 gene 2 (non-protein coding)

    Clone Names

    • MGC104305, DKFZp686F081

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003108.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC135721, BC034248, CR936675, U88573
      Related
      ENST00000460115.5

    2. NR_138145.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and includes five alternate exons, compared to variant 1.
      Source sequence(s)
      AC135721, BC022065, BC034248
      Related
      ENST00000467245.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43125557..43153671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43984189..44012426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005821.4: Suppressed sequence

      Description
      NM_005821.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials