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    TP53TG1 TP53 target 1 [ Homo sapiens (human) ]

    Gene ID: 11257, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TP53TG1provided by HGNC
    Official Full Name
    TP53 target 1provided by HGNC
    Primary source
    HGNC:HGNC:17026
    See related
    Ensembl:ENSG00000182165 MIM:616403; AllianceGenome:HGNC:17026
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53TG1; TP53AP1; P53TG1-D; TP53LC12; LINC00096; NCRNA00096
    Expression
    Ubiquitous expression in prostate (RPKM 16.5), colon (RPKM 12.1) and 25 other tissues See more
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    Genomic context

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    See TP53TG1 in Genome Data Viewer
    Location:
    7q21.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87325347..87345492, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (88574951..88595106, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86954663..86974808, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86781403-86781964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18343 Neighboring gene DMTF1 antisense RNA 1 Neighboring gene uncharacterized LOC105375384 Neighboring gene NANOG hESC enhancer GRCh37_chr7:86830979-86831516 Neighboring gene cyclin D binding myb like transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18345 Neighboring gene transmembrane protein 243 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:86959096-86960295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18346 Neighboring gene carnitine O-octanoyltransferase Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18349 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 9 Neighboring gene ATP binding cassette subfamily B member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long Noncoding RNA TP53TG1 Contributes to Radioresistance of Glioma Cells Via miR-524-5p/RAB5A Axis. Gao W, et al. Cancer Biother Radiopharm, 2021 Sep. PMID 32762546
    2. Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer. Shao M, et al. J Cell Physiol, 2020 Oct. PMID 32020607
    3. TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis. Xiao H, et al. Cell Biosci, 2018. PMID 29588850, Free PMC Article
    4. LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma. Chen X, et al. J Cell Biochem, 2017 Dec. PMID 28569381
    5. Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. Takei Y, et al. Genes Chromosomes Cancer, 1998 Sep. PMID 9713990

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
      Title: m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
    2. Comprehensive analysis of DRAIC and TP53TG1 in breast cancer luminal subtypes through the construction of lncRNAs regulatory model.
      Title: Comprehensive analysis of DRAIC and TP53TG1 in breast cancer luminal subtypes through the construction of lncRNAs regulatory model.
    3. Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.
      Title: Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.
    4. Long Noncoding RNA TP53TG1 Contributes to Radioresistance of Glioma Cells Via miR-524-5p/RAB5A Axis.
      Title: Long Noncoding RNA TP53TG1 Contributes to Radioresistance of Glioma Cells Via miR-524-5p/RAB5A Axis.
    5. Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer.
      Title: Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer.
    6. TP53TG1 could directly bind to miR-96 and effectively function as a sponge for miR-96, antagonizing the functions of miR-96 and leading to derepression of KRAS, which is a core oncogene in the initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC). TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA to competitively bind to miR-96 and regulate KRAS expression.
      Title: Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96.
    7. Study reports that TP53TG1 is an lncRNA that is critical for the correct response of p53 to DNA damage. The cancer growth suppressor features of TP53TG1 are linked to its ability to block the tumorigenic activity of the RNA binding protein YBX1. The DNA methylation-associated silencing of TP53TG1 produces aggressive tumors that are resistant to cellular death when DNAdamaging agents and small targeted molecules are used.
      Title: Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.
    8. data showed that TP53TG1 under glucose deprivation may promote cell proliferation and migration by influencing the expression of glucose metabolism related genes in glioma.
      Title: LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma.
    9. From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype.
      Title: Analysis of functional variants reveals new candidate genes associated with alexithymia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • H_RG012D21.9
    • TP53 activated protein 1
    • TP53 target 1 (non-protein coding)
    • TP53 target gene 1
    • long intergenic non-protein coding RNA 96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015381.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      BC002709
      Related
      ENST00000766320.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      87325347..87345492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      88574951..88595106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007233.1: Suppressed sequence

      Description
      NM_007233.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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