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    RPLP0 ribosomal protein lateral stalk subunit P0 [ Homo sapiens (human) ]

    Gene ID: 6175, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RPLP0provided by HGNC
    Official Full Name
    ribosomal protein lateral stalk subunit P0provided by HGNC
    Primary source
    HGNC:HGNC:10371
    See related
    Ensembl:ENSG00000089157 MIM:180510; AllianceGenome:HGNC:10371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P0; LP0; L10E; RPP0; uL10; PRLP0
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1127.2), bone marrow (RPKM 877.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPLP0 in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120196699..120201111, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120183864..120188276, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120634502..120638914, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120554541-120555332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4941 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120555445-120555623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120556125-120556916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7128 Neighboring gene RAB35 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7131 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 4498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7132 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120622010-120623209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120635999-120636498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120636618-120637559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7134 Neighboring gene Sharpr-MPRA regulatory region 12439 Neighboring gene PXN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120653807-120654533 Neighboring gene uncharacterized LOC124903034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120662858-120663539 Neighboring gene paxillin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Wang YL, et al. Cell Death Dis, 2022 Aug 16. PMID 35974014, Free PMC Article
    2. Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified and antigenically related to the acidic phosphoproteins P1/P2. Towbin H, et al. J Biol Chem, 1982 Nov 10. PMID 6182142
    3. Baculovirus-mediated expression and isolation of human ribosomal phosphoprotein P0 carrying a GST-tag in a functional state. Abo Y, et al. Biochem Biophys Res Commun, 2004 Sep 24. PMID 15336536
    4. Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome. Filipek K, et al. FEBS Lett, 2020 Sep. PMID 32668052
    5. Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients. Benvenuto M, et al. J Transl Med, 2015 Mar 28. PMID 25889931, Free PMC Article

    See all (313) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNF-alpha and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema.
      Title: TNF-α and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema.
    2. DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.
      Title: DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.
    3. Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome.
      Title: Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome.
    4. The presence of uL10 on the ribosomes is affected in stressed cells, thus it might be considered as a regulatory element responding to environmental fluctuations.
      Title: The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.
    5. absence of RPLP0, RPLP1, or RPLP2 resulted in reactive oxygen species (ROS) accumulation and MAPK1/ERK2 signaling pathway activation.
      Title: Disruption of the ribosomal P complex leads to stress-induced autophagy.
    6. This study shows a spontaneous humoral immune response to ribosomal P0 protein in colorectal cancer patients.
      Title: Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.
    7. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells
      Title: Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
    8. the immune response mediated by serum anti-RPLP0 and anti-galectin 3 antibodies plays a key role in the pathogenesis of SLE skin lesions. These findings provide new insights into the mechanism of SLE-related organ disorders.
      Title: Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus.
    9. Evaluated autoantibodies against native ribosomal P complex and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for prevalence, diagnostic relevance&clinical associations in a Chinese cohort with systemic lupus erythematosus.
      Title: Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.
    10. Results show that RPL4, RPLP0, and HSPCB were the most stable reference genes in ovarian tissues.
      Title: Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein P0 (RPLP0) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC88175, MGC111226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL10
    Names
    60S acidic ribosomal protein P0
    60S ribosomal protein L10E
    acidic ribosomal phosphoprotein P0
    neutral ribosomal phosphoprotein P0
    ribosomal protein, large, P0

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002.4 → NP_000993.1  large ribosomal subunit protein uL10

      See identical proteins and their annotated locations for NP_000993.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. It has a different 5' UTR than variant 2. They encode the same protein.
      Source sequence(s)
      AC004263, BC000087, BC019014, BF131912
      Consensus CDS
      CCDS9193.1
      UniProtKB/Swiss-Prot
      P05388, Q3B7A4, Q9BVK4
      UniProtKB/TrEMBL
      A8K4Z4, Q53HK9, Q53HW2
      Related
      ENSP00000376299.4, ENST00000392514.9
      Conserved Domains (1) summary
      PTZ00135
      Location:1 → 317
      PTZ00135; 60S acidic ribosomal protein P0; Provisional

    2. NM_053275.4 → NP_444505.1  large ribosomal subunit protein uL10

      See identical proteins and their annotated locations for NP_444505.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 5' UTR than variant 1. They encode the same protein.
      Source sequence(s)
      AC004263, BC019014, BF131912
      Consensus CDS
      CCDS9193.1
      UniProtKB/Swiss-Prot
      P05388, Q3B7A4, Q9BVK4
      UniProtKB/TrEMBL
      A8K4Z4, Q53HK9, Q53HW2
      Related
      ENSP00000339027.3, ENST00000228306.8
      Conserved Domains (1) summary
      PTZ00135
      Location:1 → 317
      PTZ00135; 60S acidic ribosomal protein P0; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120196699..120201111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120183864..120188276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05388.1 GenPept UniProtKB/Swiss-Prot:P05388

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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