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    CXCR3 C-X-C motif chemokine receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2833, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CXCR3provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4540
    See related
    Ensembl:ENSG00000186810 MIM:300574; AllianceGenome:HGNC:4540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
    Summary
    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
    Expression
    Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CXCR3 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71615919..71618511, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70049169..70051938, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70835769..70838361, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70752005-70753204 Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70798494-70799135 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene Sharpr-MPRA regulatory region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29749 Neighboring gene Sharpr-MPRA regulatory region 2992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29750 Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29752 Neighboring gene chromosome X open reading frame 49-like Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:70888661-70889860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. Korniejewska A, et al. Immunology, 2011 Apr. PMID 21255008, Free PMC Article
    2. Epithelial CXCR3-B regulates chemokines bioavailability in normal, but not in Sjogren's syndrome, salivary glands. Sfriso P, et al. J Immunol, 2006 Feb 15. PMID 16456020
    3. CXCR3A contributes to the invasion and metastasis of gastric cancer cells. Yang C, et al. Oncol Rep, 2016 Sep. PMID 27461521
    4. Candidate gene analysis of IP-10 gene in patients with Alzheimer's disease. Venturelli E, et al. Neurosci Lett, 2006 Aug 14. PMID 16787707
    5. The Role of CXCR3 in Nervous System-Related Diseases. Wang F, et al. Mediators Inflamm, 2024. PMID 39429695, Free PMC Article

    See all (336) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of CXCR3 in Nervous System-Related Diseases.
      Title: The Role of CXCR3 in Nervous System-Related Diseases.
    2. The IFN-gamma-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.
      Title: The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.
    3. Hyperactivation of beta-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
      Title: Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
    4. The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.
      Title: The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.
    5. CXCL9 and its Receptor CXCR3, an Important Link Between Inflammation and Cardiovascular Risks in RA Patients.
      Title: CXCL9 and its Receptor CXCR3, an Important Link Between Inflammation and Cardiovascular Risks in RA Patients.
    6. Role of CXCR3 in fibrotic tissue responses.
      Title: Role of CXCR3 in fibrotic tissue responses.
    7. IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways.
      Title: IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways.
    8. EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3.
      Title: EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3.
    9. Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
      Title: Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
    10. Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.
      Title: Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.
    Submit: New GeneRIF Correction See all GeneRIFs (291)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
    env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed
    Nef nef HIV-1 Nef induces variable levels of CXCR3 downregulation in different cell types PubMed
    nef Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef PubMed
    Tat tat HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed
    Vif vif HIV-1 Vif upregulates the expression of chemokine (C-X-C motif) receptor 3 (CXCR3) in Vif-expression T cells PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 3 (CXCR3, CD183) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-X-C chemokine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C-X-C chemokine receptor type 3
    Names
    G protein-coupled receptor 9
    IP-10 receptor
    Mig receptor
    chemokine (C-X-C motif) receptor 3
    chemokine receptor 3
    interferon-inducible protein 10 receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029076.1 RefSeqGene

      Range
      5007..7599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142797.2 → NP_001136269.1  C-X-C chemokine receptor type 3 isoform 2

      See identical proteins and their annotated locations for NP_001136269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).
      Source sequence(s)
      AF469635, X95876
      Consensus CDS
      CCDS48135.1
      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Related
      ENSP00000362795.4, ENST00000373691.4
      Conserved Domains (1) summary
      cd15180
      Location:101 → 376
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001504.2 → NP_001495.1  C-X-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_001495.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
      Source sequence(s)
      X95876
      Consensus CDS
      CCDS14416.1
      UniProtKB/Swiss-Prot
      B2R982, O15185, P49682, Q7Z710, Q9P2T4, Q9P2T5
      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Related
      ENSP00000362797.3, ENST00000373693.4
      Conserved Domains (1) summary
      cd15180
      Location:54 → 329
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      71615919..71618511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029436.2 → XP_016884925.1  C-X-C chemokine receptor type 3 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z3W9

    2. XM_047442010.1 → XP_047297966.1  C-X-C chemokine receptor type 3 isoform X3

    3. XM_005262257.4 → XP_005262314.1  C-X-C chemokine receptor type 3 isoform X4

      UniProtKB/TrEMBL
      A0A0S2Z3W9
      Conserved Domains (1) summary
      pfam00001
      Location:84 → 218
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. XM_005262256.4 → XP_005262313.1  C-X-C chemokine receptor type 3 isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Conserved Domains (1) summary
      pfam00001
      Location:84 → 328
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    5. XM_017029435.2 → XP_016884924.1  C-X-C chemokine receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Conserved Domains (1) summary
      cd15180
      Location:101 → 376
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      70049169..70051938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326874.1 → XP_054182849.1  C-X-C chemokine receptor type 3 isoform X4

    2. XM_054326872.1 → XP_054182847.1  C-X-C chemokine receptor type 3 isoform X2

    3. XM_054326875.1 → XP_054182850.1  C-X-C chemokine receptor type 3 isoform X5

    4. XM_054326873.1 → XP_054182848.1  C-X-C chemokine receptor type 3 isoform X3

    5. XM_054326871.1 → XP_054182846.1  C-X-C chemokine receptor type 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49682.2 GenPept UniProtKB/Swiss-Prot:P49682

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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