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    RBM41 RNA binding motif protein 41 [ Homo sapiens (human) ]

    Gene ID: 55285, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RBM41provided by HGNC
    Official Full Name
    RNA binding motif protein 41provided by HGNC
    Primary source
    HGNC:HGNC:25617
    See related
    Ensembl:ENSG00000089682 AllianceGenome:HGNC:25617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.9), skin (RPKM 2.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RBM41 in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (107052102..107118822, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105488619..105560772, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106295332..106362052, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106209370-106209870 Neighboring gene MORC family CW-type zinc finger 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20926 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106261730-106262231 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29832 Neighboring gene nucleoporin 62 C-terminal like Neighboring gene GTF3C6 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:106399301-106399461 Neighboring gene dynein axonemal assembly factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SARS-CoV-2 NSP12 utilizes various host splicing factors for replication and splicing regulation. Yang L, et al. J Med Virol, 2024 Jan. PMID 38235848
    2. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. Tong J, et al. J Proteome Res, 2008 Mar. PMID 18271526
    3. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE, et al. Nature, 2020 Jul. PMID 32353859, Free PMC Article
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Zhou Y, et al. Nat Biotechnol, 2023 Jan. PMID 36217030, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11016, FLJ13670

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables U12 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA intronic binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016385.2 RefSeqGene

      Range
      5000..61937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171080.2 → NP_001164551.1  RNA-binding protein 41 isoform 2

      See identical proteins and their annotated locations for NP_001164551.1

      Status: VALIDATED

      Source sequence(s)
      AK001878, AL390039, DA255574
      Consensus CDS
      CCDS55472.1
      UniProtKB/Swiss-Prot
      Q96IZ5
      Related
      ENSP00000361565.1, ENST00000372487.5
      Conserved Domains (1) summary
      cd12239
      Location:308 → 385
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    2. NM_001324242.2 → NP_001311171.1  RNA-binding protein 41 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Consensus CDS
      CCDS94645.1
      UniProtKB/TrEMBL
      A0A8I5KYC8
      Related
      ENSP00000509650.1, ENST00000685964.1
      Conserved Domains (2) summary
      COG0724
      Location:324 → 414
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:332 → 409
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    3. NM_001324243.1 → NP_001311172.1  RNA-binding protein 41 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (2) summary
      COG0724
      Location:359 → 449
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:367 → 444
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    4. NM_001324244.2 → NP_001311173.1  RNA-binding protein 41 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL390039

    5. NM_001394116.1 → NP_001381045.1  RNA-binding protein 41 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:351 → 423
      RRM; RNA recognition motif

    6. NM_001394117.1 → NP_001381046.1  RNA-binding protein 41 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      cd12239
      Location:343 → 420
      RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins

    7. NM_001394118.1 → NP_001381047.1  RNA-binding protein 41 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:324 → 393
      RRM; RNA recognition motif

    8. NM_001394119.1 → NP_001381048.1  RNA-binding protein 41 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:313 → 382
      RRM; RNA recognition motif

    9. NM_001394120.1 → NP_001381049.1  RNA-binding protein 41 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:310 → 382
      RRM; RNA recognition motif

    10. NM_001394121.1 → NP_001381050.1  RNA-binding protein 41 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:289 → 358
      RRM; RNA recognition motif

    11. NM_001394122.1 → NP_001381051.1  RNA-binding protein 41 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:310 → 357
      RRM; RNA recognition motif

    12. NM_001394123.1 → NP_001381052.1  RNA-binding protein 41 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      cd12239
      Location:246 → 321
      RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins

    13. NM_001394124.1 → NP_001381053.1  RNA-binding protein 41 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:246 → 318
      RRM; RNA recognition motif

    14. NM_001394125.1 → NP_001381054.1  RNA-binding protein 41 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:211 → 283
      RRM; RNA recognition motif

    15. NM_001394126.1 → NP_001381055.1  RNA-binding protein 41 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:211 → 283
      RRM; RNA recognition motif

    16. NM_001394127.1 → NP_001381056.1  RNA-binding protein 41 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL390039
      Conserved Domains (1) summary
      smart00360
      Location:206 → 259
      RRM; RNA recognition motif

    17. NM_018301.5 → NP_060771.3  RNA-binding protein 41 isoform 1

      See identical proteins and their annotated locations for NP_060771.3

      Status: VALIDATED

      Source sequence(s)
      AL390039, BC006986, DA255574
      Consensus CDS
      CCDS14526.1
      UniProtKB/Swiss-Prot
      Q5JSN7, Q5JSN8, Q96IZ5, Q9H8F7, Q9NV04
      Related
      ENSP00000361557.3, ENST00000372479.8
      Conserved Domains (1) summary
      cd12239
      Location:308 → 385
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    RNA

    1. NR_136728.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390039

    2. NR_136729.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390039

    3. NR_136730.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK023732, AL390039

    4. NR_136731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390039

    5. NR_136732.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390039

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      107052102..107118822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442237.1 → XP_047298193.1  RNA-binding protein 41 isoform X2

    2. XM_011530980.4 → XP_011529282.1  RNA-binding protein 41 isoform X1

      See identical proteins and their annotated locations for XP_011529282.1

      Conserved Domains (2) summary
      COG0724
      Location:359 → 449
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:367 → 444
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    3. XM_047442238.1 → XP_047298194.1  RNA-binding protein 41 isoform X3

    4. XM_047442242.1 → XP_047298198.1  RNA-binding protein 41 isoform X7

    5. XM_047442241.1 → XP_047298197.1  RNA-binding protein 41 isoform X6

      Related
      ENSP00000405522.1, ENST00000434854.1

    6. XM_047442243.1 → XP_047298199.1  RNA-binding protein 41 isoform X8

    7. XM_047442239.1 → XP_047298195.1  RNA-binding protein 41 isoform X4

    8. XM_047442240.1 → XP_047298196.1  RNA-binding protein 41 isoform X5

      Related
      ENSP00000433251.1, ENST00000495517.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      105488619..105560772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327351.1 → XP_054183326.1  RNA-binding protein 41 isoform X9

    2. XM_054327354.1 → XP_054183329.1  RNA-binding protein 41 isoform X10

    3. XM_054327352.1 → XP_054183327.1  RNA-binding protein 41 isoform X9

    4. XM_054327355.1 → XP_054183330.1  RNA-binding protein 41 isoform X2

    5. XM_054327353.1 → XP_054183328.1  RNA-binding protein 41 isoform X1

    6. XM_054327356.1 → XP_054183331.1  RNA-binding protein 41 isoform X3

    7. XM_054327359.1 → XP_054183334.1  RNA-binding protein 41 isoform X6

    8. XM_054327357.1 → XP_054183332.1  RNA-binding protein 41 isoform X4

    9. XM_054327358.1 → XP_054183333.1  RNA-binding protein 41 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96IZ5.2 GenPept UniProtKB/Swiss-Prot:Q96IZ5

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