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    HMGN5 high mobility group nucleosome binding domain 5 [ Homo sapiens (human) ]

    Gene ID: 79366, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HMGN5provided by HGNC
    Official Full Name
    high mobility group nucleosome binding domain 5provided by HGNC
    Primary source
    HGNC:HGNC:8013
    See related
    Ensembl:ENSG00000198157 MIM:300385; AllianceGenome:HGNC:8013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSBP1; NBP-45
    Summary
    This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in testis (RPKM 20.5), adrenal (RPKM 4.3) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HMGN5 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (81113699..81201913, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (79547434..79635633, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (80369198..80457412, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 995, pseudogene Neighboring gene voltage dependent anion channel 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29793 Neighboring gene NANOG hESC enhancer GRCh37_chrX:80482201-80482731 Neighboring gene SH3 domain binding glutamate rich protein like Neighboring gene ReSE screen-validated silencer GRCh37_chrX:80513135-80513400 Neighboring gene uncharacterized LOC124905203

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of HMGN5 expression by RNA interference induces cell cycle arrest in human lung cancer cells. Chen P, et al. Asian Pac J Cancer Prev, 2012. PMID 22994738
    2. Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo. Ji SQ, et al. J Exp Clin Cancer Res, 2012 Mar 15. PMID 22420896, Free PMC Article
    3. Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma. Liu X, et al. J Biochem Mol Toxicol, 2017 Dec. PMID 28914995
    4. HMGN5 expression in bladder cancer tissue and its role on prognosis. Wu J, et al. Eur Rev Med Pharmacol Sci, 2018 Feb. PMID 29509244
    5. The nucleosome binding protein NSBP1 is highly expressed in human bladder cancer and promotes the proliferation and invasion of bladder cancer cells. Wahafu W, et al. Tumour Biol, 2011 Oct. PMID 21695596

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
      Title: Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
    2. Prognostic value of HMGN family expression in acute myeloid leukemia.
      Title: Prognostic value of HMGN family expression in acute myeloid leukemia.
    3. HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.
      Title: HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.
    4. HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells.
      Title: HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells.
    5. HIF1A upregulated the transcription factor GATA1 and further promoted the expression of HMGN5.
      Title: Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis.
    6. HMGN5 mRNA levels were significantly elevated in bladder transitional cell carcinoma tissue compared to controls.
      Title: HMGN5 expression in bladder cancer tissue and its role on prognosis.
    7. MiR-183-3p regulated HMGN5 expression in prostate cancer cells.
      Title: microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5.
    8. Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy.
      Title: MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.
    9. High HMGN5 expression is associated with osteosarcoma invasion.
      Title: Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5.
    10. We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma
      Title: MicroRNA-409-3p Represses Glioma Cell Invasion and Proliferation by Targeting High-Mobility Group Nucleosome-Binding Domain 5.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nucleosomal DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high mobility group nucleosome-binding domain-containing protein 5
    Names
    nucleosomal binding protein 1
    nucleosome-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013234.1 RefSeqGene

      Range
      5030..93244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030763.3 → NP_110390.1  high mobility group nucleosome-binding domain-containing protein 5

      See identical proteins and their annotated locations for NP_110390.1

      Status: REVIEWED

      Source sequence(s)
      AF250329, AK094058, AL391294, DA745749
      Consensus CDS
      CCDS14448.1
      UniProtKB/Swiss-Prot
      P82970, Q5JSL1
      Related
      ENSP00000350848.2, ENST00000358130.7
      Conserved Domains (2) summary
      pfam01101
      Location:1 → 93
      HMG14_17; HMG14 and HMG17
      cl27511
      Location:61 → 281
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      81113699..81201913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442514.1 → XP_047298470.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

    2. XM_047442510.1 → XP_047298466.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

    3. XM_047442515.1 → XP_047298471.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X4

    4. XM_047442513.1 → XP_047298469.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

    5. XM_047442512.1 → XP_047298468.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X2

    6. XM_047442511.1 → XP_047298467.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      79547434..79635633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327867.1 → XP_054183842.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

    2. XM_054327864.1 → XP_054183839.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

    3. XM_054327866.1 → XP_054183841.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

    4. XM_054327868.1 → XP_054183843.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X4

    5. XM_054327865.1 → XP_054183840.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82970.1 GenPept UniProtKB/Swiss-Prot:P82970

    Gene LinkOut

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