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    LZTS1 leucine zipper tumor suppressor 1 [ Homo sapiens (human) ]

    Gene ID: 11178, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LZTS1provided by HGNC
    Official Full Name
    leucine zipper tumor suppressor 1provided by HGNC
    Primary source
    HGNC:HGNC:13861
    See related
    Ensembl:ENSG00000061337 MIM:606551; AllianceGenome:HGNC:13861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F37; FEZ1
    Summary
    This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
    Expression
    Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LZTS1 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (20246165..20303963, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (20511247..20569040, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (20103676..20161474, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18971 Neighboring gene ATPase H+ transporting V1 subunit B2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:20087870-20088370 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:20091705-20092214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:20092215-20092724 Neighboring gene RNA, U6 small nuclear 892, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:20106535-20107076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:20107077-20107620 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:20112843-20113026 Neighboring gene Sharpr-MPRA regulatory region 10012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:20129385-20129920 Neighboring gene LZTS1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18972 Neighboring gene RNA, 5S ribosomal pseudogene 257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:20186237-20186853 Neighboring gene uncharacterized LOC105379314 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:20210567-20211189 Neighboring gene NANOG hESC enhancer GRCh37_chr8:20212340-20212863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:20241249-20241750 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:20269567-20270766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102562 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:20290912-20291613 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102576 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:20315593-20316153 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:20316154-20316713 Neighboring gene NANOG hESC enhancer GRCh37_chr8:20350867-20351405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:20364504-20365243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:20365244-20365982 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:20365983-20366722 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:20367115-20367326 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102632 Neighboring gene small nucleolar RNA, C/D box 3F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma. Wang XX, et al. Hum Pathol, 2011 Oct. PMID 21419475
    2. The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway. He Y, et al. Biomed Pharmacother, 2015 Dec. PMID 26653561
    3. Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family. Syx D, et al. Dis Markers, 2015. PMID 26504261, Free PMC Article
    4. Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma. Wang XX, et al. Pathol Oncol Res, 2015 Sep. PMID 25813822, Free PMC Article
    5. LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer. Lovat F, et al. Oncotarget, 2014 Feb 28. PMID 24448468, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unveiling the oncogenic role of LZTS1 in colorectal cancer.
      Title: Unveiling the oncogenic role of LZTS1 in colorectal cancer.
    2. missense variant in the LZTS1 gene was identified in two Ehlers-Danlos syndrome patients in an extended family.
      Title: Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family.
    3. LZTS1 promoter was frequently methylated in IMPC samples.
      Title: Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma.
    4. Compared with the normal hepatocyte cells, LZTS1 expression in hepatocellular carcinoma cells was significantly lower
      Title: The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway.
    5. miR-135b expression inversely correlated with LZTS1 staining intensity and the Cutaneous Squamous Cell Carcinoma grade.
      Title: MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.
    6. Suggest that LZTS1 plays a potential tumor suppressor role in colorectal cancer progression and represents a valuable clinical prognostic marker of this disease.
      Title: The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT-mTOR signaling pathway.
    7. Lzts1 was significantly downregulated in breast cancer samples and its deregulation was associated with a higher incidence of tumor recurrence, and to a worse overall survival.
      Title: LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.
    8. miR-214 functions as an onco-miRNA in osteosarcoma, and its oncogenic effects are mediated chiefly through downregulation of LZTS1
      Title: miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.
    9. Expression of miR-135b, LZTS1, LATS2 and nuclear TAZ predicts poor outcomes of non-small-cell lung cancer.
      Title: MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.
    10. Lower levels of leucine zipper putative tumor suppressor 1 correlated with high histologic grade, lymph node metastasis, and poor prognosis.
      Title: Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Malignant tumor of esophagus
    MedGen: C0546837 OMIM: 133239 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
    EBI GWAS Catalog
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog
    Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog
    Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 1
    Names
    F37/Esophageal cancer-related gene-coding leucine-zipper motif
    leucine zipper, putative tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015834.3 RefSeqGene

      Range
      5019..62817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001362884.2 → NP_001349813.1  leucine zipper putative tumor suppressor 1

      Status: REVIEWED

      Source sequence(s)
      AC025853, AF123659, BX344344, HY107963
      Consensus CDS
      CCDS6015.1
      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
      Conserved Domains (2) summary
      pfam06818
      Location:380 → 564
      Fez1; Fez1
      cl25732
      Location:235 → 513
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_021020.5 → NP_066300.1  leucine zipper putative tumor suppressor 1

      Status: REVIEWED

      Source sequence(s)
      AC025853, AF123659, BX344344, HY107963
      Consensus CDS
      CCDS6015.1
      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
      Related
      ENSP00000370981.1, ENST00000381569.5
      Conserved Domains (2) summary
      pfam06818
      Location:380 → 564
      Fez1; Fez1
      cl25732
      Location:235 → 513
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      20246165..20303963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421309.1 → XP_047277265.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2

    2. XM_011544385.3 → XP_011542687.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
      Related
      ENSP00000265801.6, ENST00000265801.6
      Conserved Domains (2) summary
      pfam06818
      Location:380 → 564
      Fez1; Fez1
      cl25732
      Location:235 → 513
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_011544386.3 → XP_011542688.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
      Conserved Domains (2) summary
      pfam06818
      Location:380 → 564
      Fez1; Fez1
      cl25732
      Location:235 → 513
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_011544384.3 → XP_011542686.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
      Conserved Domains (2) summary
      pfam06818
      Location:380 → 564
      Fez1; Fez1
      cl25732
      Location:235 → 513
      SMC_N; RecF/RecN/SMC N terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      20511247..20569040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359679.1 → XP_054215654.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2

    2. XM_054359680.1 → XP_054215655.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2

    3. XM_054359681.1 → XP_054215656.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DSQ6, Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y250.3 GenPept UniProtKB/Swiss-Prot:Q9Y250

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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