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    ZNF800 zinc finger protein 800 [ Homo sapiens (human) ]

    Gene ID: 168850, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF800provided by HGNC
    Official Full Name
    zinc finger protein 800provided by HGNC
    Primary source
    HGNC:HGNC:27267
    See related
    Ensembl:ENSG00000048405 MIM:621007; AllianceGenome:HGNC:27267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within acinar cell differentiation and endocrine pancreas development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 2.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF800 in Genome Data Viewer
    Location:
    7q31.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127342859..127392708, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128658405..128706384, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127010097..127032762, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18590 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127032217-127032717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26585 Neighboring gene uncharacterized LOC105375490 Neighboring gene long intergenic non-protein coding RNA 3012 Neighboring gene VISTA enhancer hs1308 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene GRIP and coiled-coil domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Civelek M, et al. Am J Hum Genet, 2017 Mar 2. PMID 28257690, Free PMC Article
    2. Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation. Lin L, et al. Science, 2023 Oct 27. PMID 37883554
    3. Structured RNAs in the ENCODE selected regions of the human genome. Washietl S, et al. Genome Res, 2007 Jun. PMID 17568003, Free PMC Article
    4. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
      Title: Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43301, MGC130032, MGC130033

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acinar cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 800

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176814.5 → NP_789784.2  zinc finger protein 800

      See identical proteins and their annotated locations for NP_789784.2

      Status: VALIDATED

      Source sequence(s)
      AK309674, BC110623, BG112338, BU581251, DA888007
      Consensus CDS
      CCDS5795.1
      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0
      UniProtKB/TrEMBL
      B7Z4V7
      Related
      ENSP00000265827.3, ENST00000265827.8
      Conserved Domains (4) summary
      sd00019
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618 → 640
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:355 → 383
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:391 → 485
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      127342859..127392708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515859.4 → XP_011514161.1  zinc finger protein 800 isoform X1

      See identical proteins and their annotated locations for XP_011514161.1

      Conserved Domains (4) summary
      sd00019
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618 → 640
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:355 → 383
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:391 → 485
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    2. XM_047419942.1 → XP_047275898.1  zinc finger protein 800 isoform X2

    3. XM_006715868.5 → XP_006715931.1  zinc finger protein 800 isoform X1

      See identical proteins and their annotated locations for XP_006715931.1

      Conserved Domains (4) summary
      sd00019
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618 → 640
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:355 → 383
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:391 → 485
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    4. XM_006715869.5 → XP_006715932.1  zinc finger protein 800 isoform X2

      UniProtKB/TrEMBL
      B7Z4V7
      Conserved Domains (4) summary
      sd00019
      Location:456 → 476
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:586 → 608
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:323 → 351
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:359 → 453
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    5. XM_006715867.5 → XP_006715930.1  zinc finger protein 800 isoform X1

      See identical proteins and their annotated locations for XP_006715930.1

      Conserved Domains (4) summary
      sd00019
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618 → 640
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:355 → 383
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:391 → 485
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    6. XM_047419941.1 → XP_047275897.1  zinc finger protein 800 isoform X1

    7. XM_047419949.1 → XP_047275905.1  zinc finger protein 800 isoform X6

    8. XM_047419946.1 → XP_047275902.1  zinc finger protein 800 isoform X4

    9. XM_047419945.1 → XP_047275901.1  zinc finger protein 800 isoform X4

    10. XM_047419943.1 → XP_047275899.1  zinc finger protein 800 isoform X3

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0
      Related
      ENSP00000376988.1, ENST00000393312.5

    11. XM_047419948.1 → XP_047275904.1  zinc finger protein 800 isoform X5

    12. XM_005250181.5 → XP_005250238.1  zinc finger protein 800 isoform X3

      See identical proteins and their annotated locations for XP_005250238.1

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0
      UniProtKB/TrEMBL
      B7Z4V7
      Related
      ENSP00000376989.1, ENST00000393313.5
      Conserved Domains (4) summary
      sd00019
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618 → 640
      zf-C2H2; Zinc finger, C2H2 type
      pfam16622
      Location:355 → 383
      zf-C2H2_11; zinc-finger C2H2-type
      pfam16624
      Location:391 → 485
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

    13. XM_047419947.1 → XP_047275903.1  zinc finger protein 800 isoform X5

    14. XM_047419944.1 → XP_047275900.1  zinc finger protein 800 isoform X3

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      128658405..128706384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357402.1 → XP_054213377.1  zinc finger protein 800 isoform X1

    2. XM_054357405.1 → XP_054213380.1  zinc finger protein 800 isoform X2

    3. XM_054357401.1 → XP_054213376.1  zinc finger protein 800 isoform X1

    4. XM_054357403.1 → XP_054213378.1  zinc finger protein 800 isoform X1

    5. XM_054357404.1 → XP_054213379.1  zinc finger protein 800 isoform X2

    6. XM_054357400.1 → XP_054213375.1  zinc finger protein 800 isoform X1

    7. XM_054357413.1 → XP_054213388.1  zinc finger protein 800 isoform X6

    8. XM_054357410.1 → XP_054213385.1  zinc finger protein 800 isoform X4

    9. XM_054357407.1 → XP_054213382.1  zinc finger protein 800 isoform X3

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0

    10. XM_054357412.1 → XP_054213387.1  zinc finger protein 800 isoform X5

    11. XM_054357406.1 → XP_054213381.1  zinc finger protein 800 isoform X3

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0

    12. XM_054357409.1 → XP_054213384.1  zinc finger protein 800 isoform X4

    13. XM_054357408.1 → XP_054213383.1  zinc finger protein 800 isoform X3

      UniProtKB/Swiss-Prot
      Q2TB10, Q9HBN0

    14. XM_054357411.1 → XP_054213386.1  zinc finger protein 800 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TB10.1 GenPept UniProtKB/Swiss-Prot:Q2TB10

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