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    NUDT17 nudix hydrolase 17 [ Homo sapiens (human) ]

    Gene ID: 200035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUDT17provided by HGNC
    Official Full Name
    nudix hydrolase 17provided by HGNC
    Primary source
    HGNC:HGNC:26618
    See related
    Ensembl:ENSG00000186364 AllianceGenome:HGNC:26618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in skin (RPKM 3.7), endometrium (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NUDT17 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145845630..145848954)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144962433..144965757)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145586114..145589438, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD160 molecule Neighboring gene ring finger protein 115 Neighboring gene MPRA-validated peak399 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr1:145629590-145630098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1611 Neighboring gene RNA polymerase III subunit C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1614 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145584188-145585387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1265 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145562391-145562908 Neighboring gene ankyrin repeat domain 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145556249-145557232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association between NUDT17 polymorphisms and breast cancer risk. Han J, et al. Expert Rev Mol Diagn, 2024 May. PMID 38756100
    2. Multiple Nudix family proteins possess mRNA decapping activity. Song MG, et al. RNA, 2013 Mar. PMID 23353937, Free PMC Article
    3. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between NUDT17 polymorphisms and breast cancer risk.
      Title: Association between NUDT17 polymorphisms and breast cancer risk.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate-linked moiety X motif 17
    Names
    nudix (nucleoside diphosphate linked moiety X)-type motif 17
    nudix motif 17
    NP_001012776.1
    XP_011507562.1
    XP_016856049.1
    XP_047304603.1
    XP_054190904.1
    XP_054190905.1
    XP_054190906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012758.3 → NP_001012776.1  nucleoside diphosphate-linked moiety X motif 17

      See identical proteins and their annotated locations for NP_001012776.1

      Status: VALIDATED

      Source sequence(s)
      AC239808
      Consensus CDS
      CCDS72865.1
      UniProtKB/Swiss-Prot
      P0C025
      Related
      ENSP00000334437.5, ENST00000334513.6
      Conserved Domains (1) summary
      cd04694
      Location:92 → 234
      Nudix_Hydrolase_35; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      145845630..145848954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509260.3 → XP_011507562.1  nucleoside diphosphate-linked moiety X motif 17 isoform X1

      Conserved Domains (1) summary
      cl00447
      Location:55 → 164
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. XM_047448647.1 → XP_047304603.1  nucleoside diphosphate-linked moiety X motif 17 isoform X2

      Related
      ENST00000477878.5

    3. XM_017000560.2 → XP_016856049.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

    RNA

    1. XR_007095715.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      144962433..144965757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334929.1 → XP_054190904.1  nucleoside diphosphate-linked moiety X motif 17 isoform X1

    2. XM_054334930.1 → XP_054190905.1  nucleoside diphosphate-linked moiety X motif 17 isoform X2

    3. XM_054334931.1 → XP_054190906.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

    RNA

    1. XR_008485958.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C025.2 GenPept UniProtKB/Swiss-Prot:P0C025

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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