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    ADORA2A-AS1 ADORA2A antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 646023, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ADORA2A-AS1provided by HGNC
    Official Full Name
    ADORA2A antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:37122
    See related
    Ensembl:ENSG00000178803 AllianceGenome:HGNC:37122
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C22orf45; hLinfRNA1
    Annotation information
    Note: This locus has been reported as a novel protein-coding gene (Knowled and McLysaght, PMID: 19726446). NCBI has noted that there is uncertainty about the correct definition of the full-length transcript and which of the predicted short open reading frames is translated. Therefore, we have elected to represent the locus as non-coding until additional data supporting a specific protein product becomes available. [13 Feb 2013]
    Expression
    Biased expression in testis (RPKM 3.7), kidney (RPKM 2.7) and 10 other tissues See more
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    Genomic context

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    See ADORA2A-AS1 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (24429206..24495074, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24890818..24956691, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24825174..24891042, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SPECC1L-ADORA2A readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24680125-24680630 Neighboring gene ribosomal protein S10 pseudogene 29 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 like Neighboring gene Sharpr-MPRA regulatory region 3008 Neighboring gene Sharpr-MPRA regulatory region 3699 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:24712259-24712996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24734941-24735636 Neighboring gene uncharacterized LOC105372960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24804357-24804858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24804859-24805358 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24813636-24813812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24814323-24814932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24816151-24816760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24817371-24817980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24820284-24820935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24820936-24821586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24825428-24826389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24829365-24829914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24831043-24831543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13551 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24840685-24840876 Neighboring gene adenosine A2a receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18773 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24875502-24875689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24901494-24902032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24902033-24902569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18776 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24905414-24905687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18778 Neighboring gene beta-ureidopropionase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18779 Neighboring gene guanylyl cyclase domain containing 1 Neighboring gene small nuclear ribonucleoprotein D3 polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia. Liu Y, et al. Bioengineered, 2022 Feb. PMID 35034552, Free PMC Article
    2. Recent de novo origin of human protein-coding genes. Knowles DG, et al. Genome Res, 2009 Oct. PMID 19726446, Free PMC Article
    3. Novel long non-coding RNAs associated with inflammation and macrophage activation in human. Chini A, et al. Sci Rep, 2023 Mar 10. PMID 36899011, Free PMC Article
    4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Navarini AA, et al. Nat Commun, 2014 Jun 13. PMID 24927181
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia.
      Title: Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia.
    2. C22orf45 is a novel human-specific protein-coding gene.
      Title: Recent de novo origin of human protein-coding genes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • human Long-noncoding inflammation associated RNA 1

    Clone Names

    • FLJ34651

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028483.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is shorter and differs at the 3' end compared to variant 1. The protein coding capacity of this transcript is unknown.
      Source sequence(s)
      BC045098, DA917327, DB449907
      Related
      ENST00000427813.6

    2. NR_028484.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. The protein-coding potential of this transcript is unknown.
      Source sequence(s)
      AP000355
      Related
      ENST00000326341.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      24429206..24495074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24890818..24956691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039784.1: Suppressed sequence

      Description
      NM_001039784.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86434.1 GenPept UniProtKB/Swiss-Prot:P86434

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials