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    Rbm17 RNA binding motif protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291295, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rbm17provided by RGD
    Official Full Name
    RNA binding motif protein 17provided by RGD
    Primary source
    RGD:1311208
    See related
    EnsemblRapid:ENSRNOG00000018767 AllianceGenome:RGD:1311208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 272.1), Spleen (RPKM 177.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm17 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71846941..71863834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66937140..66954034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70586345..70603289)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 5-like, pseudogene 2 Neighboring gene interleukin 2 receptor subunit alpha Neighboring gene proteasome 26S subunit, ATPase 6, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene uncharacterized LOC120097756 Neighboring gene uncharacterized LOC134482599

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Corsini L, et al. Nat Struct Mol Biol, 2007 Jul. PMID 17589525
    2. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, et al. Nature, 2008 Apr 10. PMID 18337722, Free PMC Article
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013058.1 → NP_001013076.1  splicing factor 45

      See identical proteins and their annotated locations for NP_001013076.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079248
      UniProtKB/TrEMBL
      A0A8I5ZW65, Q6AY02
      Related
      ENSRNOP00000083907.1, ENSRNOT00000106718.2
      Conserved Domains (2) summary
      pfam01585
      Location:235 → 279
      G-patch; G-patch domain
      cd12647
      Location:307 → 401
      RRM_UHM_SPF45; RNA recognition motif (RRM) found in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71846941..71863834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254205.4 → XP_006254267.1  splicing factor 45 isoform X1

      See identical proteins and their annotated locations for XP_006254267.1

      UniProtKB/TrEMBL
      A0A8I5ZW65, Q6AY02
      Related
      ENSRNOP00000025550.3, ENSRNOT00000025550.8
      Conserved Domains (2) summary
      pfam01585
      Location:235 → 279
      G-patch; G-patch domain
      cd12647
      Location:307 → 401
      RRM_UHM_SPF45; RNA recognition motif (RRM) found in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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