pde6ha phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pde6haprovided by ZNC
Official Full Name: phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1754
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-1754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pde6h; zgc:73310
Summary: Predicted to enable 3',5'-cyclic-GMP phosphodiesterase activity and cGMP binding activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within visual perception. Predicted to be active in photoreceptor outer segment membrane. Is expressed in eye; retina; and retinal cone cell. Orthologous to human PDE6H (phosphodiesterase 6H). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 6

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (356155..356961, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (326186..332958, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, our results support different regulation for the zebrafish photopic and scotopic sensitivities and suggest circadian regulation of pde6ha as a key factor regulating photopic sensitivity, while the regulatory mechanisms in rods appear to be more complex.
Title: Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision.

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General gene information

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Markers

aa605734 (e-PCR)
- UniSTS:186891

fk60c03.x1 (e-PCR)
- UniSTS:201287

fj44c03.x1 (e-PCR)
- UniSTS:188566

fk53b08.x1 (e-PCR)
- UniSTS:201137

fk35b04.y1 (e-PCR)
- UniSTS:200882

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3',5'-cyclic-GMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in photoreceptor outer segment membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a

NP_001292483.1

EC 3.1.4.17

NP_957079.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305554.1 → NP_001292483.1 phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a

See identical proteins and their annotated locations for NP_001292483.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

EH437109, EH444239

UniProtKB/TrEMBL

A0A0R4IJS4, A8KC10, Q6PBP4

Conserved Domains (1) summary

pfam04868
Location:6 → 73

PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit
NM_200785.1 → NP_957079.1 phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a

See identical proteins and their annotated locations for NP_957079.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC059633

UniProtKB/TrEMBL

A0A0R4IJS4, A8KC10, Q6PBP4

Conserved Domains (1) summary

pfam04868
Location:6 → 73

PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit