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    mapk3 mitogen-activated protein kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 399480, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mapk3provided by ZNC
    Official Full Name
    mitogen-activated protein kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040121-1
    See related
    Ensembl:ENSDARG00000070573 AllianceGenome:ZFIN:ZDB-GENE-040121-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ERK1; zERK1; fi06b09; wu:fi06b09
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including central nervous system development; cranial skeletal system development; and eye development. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cranium; digestive system; and heart. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mapk3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26211974..26222308, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26081103..26091437, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene yippee-like 3 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3a Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 Neighboring gene protein phosphatase 4, catalytic subunit a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of mitogen-activated protein kinase-3 (MAPK3) and its regulation of the promoter region in zebrafish. Chiou MJ, et al. DNA Cell Biol, 2007 Nov. PMID 17999625
    2. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Gusev A, et al. Nat Genet, 2018 Apr. PMID 29632383, Free PMC Article
    3. Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines. Snaar-Jagalska BE, et al. Glycobiology, 2003 Oct. PMID 12881410
    4. Relative importance of phosphatidylinositol-3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK3/1) signaling during maturational steroid-induced meiotic G2-M1 transition in zebrafish oocytes. Das D, et al. Zygote, 2018 Feb. PMID 29229010
    5. Sequence and expression analysis of extracellular signal-regulated kinase 1 from flounder (Paralichthys olivaceous). Lee YS, et al. Fish Shellfish Immunol, 2010 Jan. PMID 19804835

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPK3 role in the oocyte maturation
      Title: Relative importance of phosphatidylinositol-3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK3/1) signaling during maturational steroid-induced meiotic G2-M1 transition in zebrafish oocytes.
    2. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
      Title: ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
    3. Data define distinct roles for ERK1 and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
      Title: Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.
    4. eena plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 pathway
      Title: eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish.
    5. These results demonstrate that induction of Hsp70 in response to heat stress is dependent on ERK activation in Pac2 cells.
      Title: Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells.
    6. ERK1 and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
      Title: ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 3
    NP_958915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201507.1 → NP_958915.1  mitogen-activated protein kinase 3

      See identical proteins and their annotated locations for NP_958915.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045505
      UniProtKB/TrEMBL
      B2GNH0, Q7ZVK8
      Related
      ENSDARP00000094521.4, ENSDART00000103746.6
      Conserved Domains (2) summary
      smart00220
      Location:56 → 344
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07849
      Location:50 → 384
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      26211974..26222308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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