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    akt2l v-akt murine thymoma viral oncogene homolog 2, like [ Danio rerio (zebrafish) ]

    Gene ID: 403146, updated on 2-Nov-2024

    Summary

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    Official Symbol
    akt2lprovided by ZNC
    Official Full Name
    v-akt murine thymoma viral oncogene homolog 2, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040121-5
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040121-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Is expressed in digestive system; lens; pectoral fin musculature; solid lens vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See akt2l in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (311721..322769, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (311721..321124, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene EMSY transcriptional repressor, BRCA2 interacting Neighboring gene wu:fj39h09 Neighboring gene vasodilator stimulated phosphoprotein a Neighboring gene zgc:171929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation. Zhao W, et al. Environ Sci Pollut Res Int, 2019 Feb. PMID 30539402
    2. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. Cheng YC, et al. PLoS One, 2013. PMID 23342113, Free PMC Article
    3. FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development. Stuckenholz C, et al. Gastroenterology, 2009 Oct. PMID 19563808, Free PMC Article
    4. Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Michailidou C, et al. Dis Model Mech, 2009 Jul-Aug. PMID 19470611
    5. Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Feng N, et al. Singapore Med J, 2019 May. PMID 30402654, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    v-akt murine thymoma viral oncogene homolog 2, like
    NP_997980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212815.2 → NP_997980.1  v-akt murine thymoma viral oncogene homolog 2, like

      See identical proteins and their annotated locations for NP_997980.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046892
      UniProtKB/TrEMBL
      Q802Y3
      Conserved Domains (4) summary
      cd05595
      Location:153 → 475
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      smart00220
      Location:149 → 406
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:4 → 111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 106
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      311721..322769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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