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    fbxo32 F-box protein 32 [ Danio rerio (zebrafish) ]

    Gene ID: 393891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbxo32provided by ZNC
    Official Full Name
    F-box protein 32provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1040
    See related
    Ensembl:ENSDARG00000040277 AllianceGenome:ZFIN:ZDB-GENE-040426-1040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atrogin1; zgc:56479
    Summary
    Acts upstream of or within several processes, including cardiac muscle tissue morphogenesis; larval locomotory behavior; and muscle cell cellular homeostasis. Located in cytoplasm. Is expressed in cardiac muscle cell; muscle; skeletal muscle; skeletal muscle cell; and yolk syncytial layer. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fbxo32 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25259313..25272633)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25344281..25357601)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene LRAT domain containing 2b Neighboring gene kelch-like family member 38b Neighboring gene PRELI domain containing 3A Neighboring gene si:dkey-29h14.10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model. Niedbalska-Tarnowska J, et al. Cells, 2022 Apr 11. PMID 35455976, Free PMC Article
    2. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. Cao P, et al. FASEB J, 2009 Sep. PMID 19406843, Free PMC Article
    3. Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio). Pasha R, et al. Environ Toxicol Pharmacol, 2017 Jun. PMID 28414942
    4. Molecular characterization of atrogin-1/F-box protein-32 (FBXO32) and F-box protein-25 (FBXO25) in rainbow trout (Oncorhynchus mykiss): Expression across tissues in response to feed deprivation. Cleveland BM, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Nov. PMID 20601059
    5. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Bühler A, et al. Int J Mol Sci, 2016 Jan 30. PMID 26840306, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56479

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 32
    Names
    atrogin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200917.1 → NP_957211.1  F-box only protein 32

      See identical proteins and their annotated locations for NP_957211.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052112
      UniProtKB/TrEMBL
      Q7ZTY2
      Related
      ENSDARP00000058937.4, ENSDART00000058938.5
      Conserved Domains (2) summary
      pfam06881
      Location:254 → 303
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam12937
      Location:226 → 272
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      25259313..25272633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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