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    spink2.1 serine peptidase inhibitor, Kazal type 2, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 565497, updated on 17-Aug-2024

    Summary

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    Official Symbol
    spink2.1provided by ZNC
    Official Full Name
    serine peptidase inhibitor, Kazal type 2, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-972
    See related
    Ensembl:ENSDARG00000102076 AllianceGenome:ZFIN:ZDB-GENE-070112-972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158852
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (15155684..15156724)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14850121..14851161)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene NK1 transcription factor related 2-like,b Neighboring gene UV-stimulated scaffold protein A Neighboring gene trypsin inhibitor ClTI-1-like Neighboring gene serine peptidase inhibitor, Kazal type 2, tandem duplicate 2 Neighboring gene serine peptidase inhibitor, Kazal type 2, tandem duplicate 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC158852

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 2.1
    Names
    serine protease inhibitor Kazal-type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198751.1 → NP_001185680.1  serine protease inhibitor Kazal-type 2.1 precursor

      Status: VALIDATED

      Source sequence(s)
      CR382342, EH553231, EH572792
      UniProtKB/TrEMBL
      A0A0R4IIR6, A0A8M1NUY1
      Related
      ENSDARP00000134195.1, ENSDART00000167966.2
      Conserved Domains (1) summary
      pfam00050
      Location:29 → 77
      Kazal_1; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      15155684..15156724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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