crebbpa CREB binding protein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crebbpaprovided by ZNC
Official Full Name: CREB binding protein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-439
See related: Ensembl:ENSDARG00000104609 AllianceGenome:ZFIN:ZDB-GENE-050208-439
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cbp-b; crebbp; si:dkey-206l1.6; si:dkey-44g23.1
Summary: Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (26702788..26790743)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (26840341..26928291)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk81e09.x1 (e-PCR)
- UniSTS:201569

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CREB-binding protein

Names: CREB binding protein (Rubinstein-Taybi syndrome); CREBBPb

XP_005161826.1

EC 2.3.1.48

XP_005161827.1

EC 2.3.1.48

XP_005161828.1

EC 2.3.1.48

XP_021329191.1

EC 2.3.1.48

XP_021329192.1

EC 2.3.1.48

XP_021329193.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

26702788..26790743

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161769.4 → XP_005161826.1 CREB-binding protein isoform X1

UniProtKB/TrEMBL

A0A8M2B8L6

Related

ENSDARP00000137457.1, ENSDART00000158756.2

Conserved Domains (11) summary

cd05495
Location:980 → 1087

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

PHA03193
Location:751 → 919

PHA03193; tegument protein VP11/12; Provisional

smart00551
Location:1659 → 1737

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1598 → 1638

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1902 → 2333

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1099 → 1171

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1172 → 1206

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam02172
Location:548 → 628

KIX; KIX domain

pfam08214
Location:1235 → 1542

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1957 → 2043

Creb_binding; Creb binding
XM_005161770.4 → XP_005161827.1 CREB-binding protein isoform X2

UniProtKB/TrEMBL

A0A0R4IPF2, A0A8M2B8J6

Related

ENSDARP00000135614.1, ENSDART00000166775.3

Conserved Domains (10) summary

cd05495
Location:979 → 1086

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1658 → 1736

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1597 → 1637

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1901 → 2332

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1098 → 1170

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1171 → 1205

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam02172
Location:548 → 628

KIX; KIX domain

pfam08214
Location:1234 → 1541

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1956 → 2042

Creb_binding; Creb binding
XM_005161771.4 → XP_005161828.1 CREB-binding protein isoform X3

UniProtKB/TrEMBL

A0A2R8Q4T2, A0A8M2B8N6

Related

ENSDARP00000147838.1, ENSDART00000187997.1

Conserved Domains (11) summary

cd05495
Location:897 → 1004

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1576 → 1654

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1515 → 1555

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1819 → 2250

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1016 → 1088

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1089 → 1123

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam02172
Location:548 → 628

KIX; KIX domain

pfam03153
Location:635 → 837

TFIIA; Transcription factor IIA, alpha/beta subunit

pfam08214
Location:1152 → 1459

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1874 → 1960

Creb_binding; Creb binding

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395113.1 Reference GRCz11 ALT_DRER_TU_1

Range

7723..60810

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473516.1 → XP_021329191.1 CREB-binding protein isoform X4

UniProtKB/TrEMBL

A0A8M9Q3D9

Conserved Domains (12) summary

cd05495
Location:980 → 1087

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

cd02337
Location:1598 → 1638

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1099 → 1171

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1172 → 1206

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02172
Location:548 → 628

KIX; KIX domain

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam08214
Location:1235 → 1542

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1956 → 2044

Creb_binding; Creb binding

pfam09606
Location:1877 → 2330

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl26464
Location:1758 → 1841

Atrophin-1; Atrophin-1 family

cl27975
Location:653 → 895

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

cl28295
Location:784 → 988

PKS_KS; Beta-ketoacyl synthase
XM_021473517.1 → XP_021329192.1 CREB-binding protein isoform X5

UniProtKB/TrEMBL

A0A8M9PDM0

Conserved Domains (11) summary

cd05495
Location:979 → 1086

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

cd02337
Location:1597 → 1637

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1098 → 1170

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1171 → 1205

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02172
Location:548 → 628

KIX; KIX domain

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam08214
Location:1234 → 1541

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1955 → 2043

Creb_binding; Creb binding

pfam09606
Location:1876 → 2329

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25496
Location:642 → 912

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl26464
Location:1757 → 1840

Atrophin-1; Atrophin-1 family
XM_021473518.1 → XP_021329193.1 CREB-binding protein isoform X6

UniProtKB/TrEMBL

A0A8M9PQB0

Conserved Domains (11) summary

cd05495
Location:897 → 1004

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

cd02337
Location:1515 → 1555

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1016 → 1088

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15647
Location:1089 → 1123

PHD_CBP; PHD finger found in CREB-binding protein (CBP)

pfam02172
Location:548 → 628

KIX; KIX domain

pfam02135
Location:325 → 392

zf-TAZ; TAZ zinc finger

pfam08214
Location:1152 → 1459

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1873 → 1961

Creb_binding; Creb binding

pfam09606
Location:1794 → 2247

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25751
Location:751 → 897

DUF4045; Domain of unknown function (DUF4045)

cl26464
Location:1675 → 1758

Atrophin-1; Atrophin-1 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001089455.2: Suppressed sequence

Description

NM_001089455.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.