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    slc12a8 solute carrier family 12 member 8 [ Danio rerio (zebrafish) ]

    Gene ID: 100000006, updated on 12-Sep-2024

    Summary

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    Official Symbol
    slc12a8provided by ZNC
    Official Full Name
    solute carrier family 12 member 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5654
    See related
    Ensembl:ENSDARG00000074384 AllianceGenome:ZFIN:ZDB-GENE-030131-5654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi11e03; wu:fi11e03; si:dkey-101k6.7
    Summary
    Predicted to enable potassium:chloride symporter activity. Acts upstream of or within cilium assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See slc12a8 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38642800..38682252)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38832876..38872453)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 4 Neighboring gene zinc finger protein 148 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene taste receptor, type 2, member 201, tandem duplicate 1 Neighboring gene KAT8 regulatory NSL complex subunit 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Wang X, et al. Chemosphere, 2016 Feb. PMID 26595314
    2. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 8
    Names
    solute carrier family 12 (potassium/chloride transporters), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128277.1 → NP_001121749.1  solute carrier family 12 member 8

      See identical proteins and their annotated locations for NP_001121749.1

      Status: PROVISIONAL

      Source sequence(s)
      BX255930, CR933561
      UniProtKB/TrEMBL
      A0A8M1NJU0, A9C3V4
      Related
      ENSDARP00000122480.1, ENSDART00000135774.3
      Conserved Domains (1) summary
      TIGR00930
      Location:21 → 389
      2a30; K-Cl cotransporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      38642800..38682252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167802.5 → XP_005167859.1  solute carrier family 12 member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BF89
      Conserved Domains (1) summary
      TIGR00930
      Location:32 → 400
      2a30; K-Cl cotransporter
    Nucleotide Protein
    Heading Accession and Version

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