mccc2 methylcrotonyl-CoA carboxylase subunit 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mccc2provided by ZNC
Official Full Name: methylcrotonyl-CoA carboxylase subunit 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2493
See related: Ensembl:ENSDARG00000017571 AllianceGenome:ZFIN:ZDB-GENE-040426-2493
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85685; si:dkey-57m14.1
Summary: Predicted to enable ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Predicted to be part of methylcrotonoyl-CoA carboxylase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (43808838..43819507, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (43208685..43219354, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
contributes_to methylcrotonoyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylcrotonoyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of methylcrotonoyl-CoA carboxylase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

Names: methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

NP_998092.1

EC 6.4.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212927.1 → NP_998092.1 methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

See identical proteins and their annotated locations for NP_998092.1

Status: PROVISIONAL

Source sequence(s)

BC067577

UniProtKB/TrEMBL

Q6NWI5

Related

ENSDARP00000023819.8, ENSDART00000022481.9

Conserved Domains (2) summary

PLN02820
Location:39 → 566

PLN02820; 3-methylcrotonyl-CoA carboxylase, beta chain

cl23717
Location:347 → 485

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...